Protein detail
CNTN1
Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
Protein symbol CNTN1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Ensembl
Entrez Gene Symbol
Gene Synonym
F3GP135
Gene Description
Contactin 1
Chromosome
12
Position
40692439-41072415
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificBrain excitatory neuronsBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-2122948 activated notch1 transmits signal to the nucleus
- R-hsa-373760 l1cam interactions
- R-hsa-9675108 nervous system development
- R-hsa-447043 neurofascin interactions
- R-hsa-2979096 notch2 activation and transmission of signal to the nucleus
- R-hsa-157118 signaling by notch
- R-hsa-1980143 signaling by notch1
- R-hsa-1980145 signaling by notch2
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
55 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | No | Yes | Yes |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | Yes |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | Yes |
| receptor | receptor | LRdb | No | Yes | No | Yes | Yes |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | Yes |
| other_receptor_family | receptor | HPMR | No | Yes | No | Yes | Yes |
| transferrin | receptor | HPMR | No | Yes | No | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | No | Yes | Yes |
| extracellular | extracellular | HPMR | No | No | No | Yes | Yes |
| extracellular | extracellular | LOCATE | No | No | No | Yes | Yes |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CNTN1 | Q12860 | NOTC1 | P46531 | Yes | Yes | No | WangCellChatDBCellPhoneDBNetPathICELLNETconnectomeDB2020HPRDCui2007SignaLink3SPIKE_LCSPIKE | HPRD:14567914connectomeDB2020:14567914NetPath:14567914SignaLink3:14567914CellChatDB:14567914SPIKE:14567914ICELLNET:14567914SPIKE_LC:14567914SPIKE_LC:16713569SignaLink3:23331499SPIKE:16713569 |
| CNTP1 | P78357 | CNTN1 | Q12860 | Yes | Yes | No | HPMRWangSIGNOR | HPMR:9118959SIGNOR:11069942 |
| CNTP2 | Q9UHC6 | CNTN1 | Q12860 | Yes | Yes | No | SIGNOR | SIGNOR:11069942 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass Spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,018
Mass
113,320
Sequence
MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q12860-1; Sequence=Displayed; Name=2; IsoId=Q12860-2; Sequence=VSP_002500; Name=3; IsoId=Q12860-3; Sequence=VSP_011959, VSP_011960
Alternative Sequence
21..31; Missing (in isoform 2); 603..627; PPGPPGGLRIEDIRATSVALTWSRG -> KNRKGGEKNMVDSFLPVCASLPPTW (in isoform 3); 628..1018; Missing (in isoform 3)
3D Structural Models
Turn
191..193; 290..293
Helix
203..205; 216..218; 302..304; 851..853
Beta Strand
146..149; 154..156; 162..166; 169..176; 184..189; 196..200; 207..215; 220..223; 227..232; 240..247; 251..254; 259..269; 272..277; 287..289; 294..297; 306..314; 317..328; 816..821; 824..828; 839..849; 855..860; 864..868; 876..884; 886..888; 896..899
3D Structure
NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
41..131; Ig-like C2-type 1; 137..223; Ig-like C2-type 2; 241..326; Ig-like C2-type 3; 331..407; Ig-like C2-type 4; 413..500; Ig-like C2-type 5; 504..601; Ig-like C2-type 6; 606..704; Fibronectin type-III 1; 709..806; Fibronectin type-III 2; 811..906; Fibronectin type-III 3; 907..1000; Fibronectin type-III 4
Region
693..717; Disordered
Protein Families
- Immunoglobulin superfamily
- Contactin family
Sequence Similarities
Belongs to the immunoglobulin superfamily. Contactin family.
Clinical Relevance
Drugs