Protein detail

CNTN1

Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)

Entry name CNTN1	UniProt ID Q12860	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)

Protein Class (4)

Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Ensembl

ENSG00000018236

Entrez Gene Symbol

CNTN1

Gene Synonym (2)

F3GP135

Gene Description

Contactin 1

Chromosome

Position

40692439-41072415

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Cell SpecificBrain excitatory neuronsBlood Cell Specificnaive CD4 T-cellBlood Lineage SpecificT-cells

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component (8)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (8)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence60

Ligand-Receptor Signaling (55)

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	Yes
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	Yes
matrix_adhesion	matrix_adhesion	Cellinker	No	Yes	No	Yes	Yes
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	Yes
matrix_adhesion	matrix_adhesion	OmniPath	No	Yes	No	Yes	Yes
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	Yes
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	Yes
transmembrane	transmembrane	TopDB	No	No	No	Yes	Yes
transmembrane	transmembrane	LOCATE	No	No	No	Yes	Yes

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CNTN1	Q12860	NOTC1	P46531	Yes	Yes	No	WangCellChatDBCellPhoneDBNetPathICELLNETconnectomeDB2020HPRDCui2007SignaLink3SPIKE_LCSPIKE	HPRD:14567914 connectomeDB2020:14567914 NetPath:14567914 SignaLink3:14567914 CellChatDB:14567914 SPIKE:14567914 ICELLNET:14567914 SPIKE_LC:14567914 SPIKE_LC:16713569 SignaLink3:23331499 SPIKE:16713569
CNTP1	P78357	CNTN1	Q12860	Yes	Yes	No	HPMRWangSIGNOR	HPMR:9118959 SIGNOR:11069942
CNTP2	Q9UHC6	CNTN1	Q12860	Yes	Yes	No	SIGNOR	SIGNOR:11069942

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CNTN1_CNTNAP1	CNTN1 CNTNAP1	P78357 Q12860	0:0	CellinkerCellChatDB

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass Spectrometry	1	32384937

Sequence, Structure & Domains13

Sequences

Length

1,018

Mass

113,320

Sequence

MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q12860-1; Sequence=Displayed; Name=2; IsoId=Q12860-2; Sequence=VSP_002500; Name=3; IsoId=Q12860-3; Sequence=VSP_011959, VSP_011960

Alternative Sequence

21..31; Missing (in isoform 2); 603..627; PPGPPGGLRIEDIRATSVALTWSRG -> KNRKGGEKNMVDSFLPVCASLPPTW (in isoform 3); 628..1018; Missing (in isoform 3)

3D Structural Models

Turn

191..193; 290..293

Helix

203..205; 216..218; 302..304; 851..853

Beta Strand

146..149; 154..156; 162..166; 169..176; 184..189; 196..200; 207..215; 220..223; 227..232; 240..247; 251..254; 259..269; 272..277; 287..289; 294..297; 306..314; 317..328; 816..821; 824..828; 839..849; 855..860; 864..868; 876..884; 886..888; 896..899

3D Structure

NMR spectroscopy (1); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

41..131; Ig-like C2-type 1; 137..223; Ig-like C2-type 2; 241..326; Ig-like C2-type 3; 331..407; Ig-like C2-type 4; 413..500; Ig-like C2-type 5; 504..601; Ig-like C2-type 6; 606..704; Fibronectin type-III 1; 709..806; Fibronectin type-III 2; 811..906; Fibronectin type-III 3; 907..1000; Fibronectin type-III 4

Region

693..717; Disordered

Protein Families (2)

Immunoglobulin superfamily
Contactin family

Sequence Similarities

Belongs to the immunoglobulin superfamily. Contactin family.

Clinical Relevance2

Drugs

S-ALLYLGLYCINE

Antibody (2)

CAB025200 HPA070467

Supporting Publications1

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available