Protein detail

MERTK

Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)

Entry name MERTK	UniProt ID Q12866	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Nervous system diseases:Eye disease

Transmembrane

506..526; Helical

Transmembrane Count

Ensembl

ENSG00000153208

Entrez Gene Symbol

MERTK

Gene Synonym (4)

c-EykmerRP38Tyro12

Gene Description

MER proto-oncogene, tyrosine kinase

Chromosome

Position

111898607-112029561

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificlymphoid tissueCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificleukocyte

Function & Pathway7

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (5)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04148 Efferocytosis

Reactome (6)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence71

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MERTK	IGF1R	P08069	Y	753	phosphorylation	KEA	KEA:17570479
MERTK	IGF1R	P08069	Y	754	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (63)

63 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GAS6	Q14393	MERTK	Q12866	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3InnateDBHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HINT:8939948 Cellinker:8939948 Guide2Pharma:8939948 HPRD:8939948 Cellinker:27801848 LRdb:9160883 scConnect:8939948 CellChatDB:27801848 Cellinker:9160883 SIGNOR:8939948 HPMR:9160883 ICELLNET:9160883LRdb:894SignaLink3:23331499 connectomeDB2020:8939948 CellTalkDB:9160883 InnateDB:9160883 SignaLink3:8939948 connectomeDB2020:9160883 HINT:9160883
MERTK	Q12866	VAV	P15498	Yes	Yes	No	InnateDBHPRDSignaLink3	SignaLink3:12920122 HPRD:12920122 InnateDB:12920122 SignaLink3:23331499
MERTK	Q12866	MLKL	Q8NB16	Yes	Yes	No	SIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:31230815
MERTK	Q12866	STA5B	P51692	Yes	No	No	PhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:16772534 PhosphoSite:23980167 PhosphoSite:12411494 PhosphoSite:17997837 PhosphoSite:18550772 PhosphoSite:17822672 PhosphoSite:11751923

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MERTK	Q12866	2	PDB	PDB:5k0xPDB:7cqePDB:4mhaPDB:4mh7PDB:3bprPDB:7m5zPDB:4m3qPDB:2p0cPDB:5td2PDB:5k0kPDB:5u6cPDB:7avxPDB:7aw4PDB:7oamPDB:7dxlPDB:6mepPDB:5tc0PDB:3brbPDB:3tcp

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	R Sequencing	1	32384937

Sequence, Structure & Domains10

Sequences

Length

999

Mass

110,249

Sequence

MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM

3D Structural Models

Turn

733..735

Helix

571..580; 584..586; 628..643; 679..685; 697..716; 726..728; 758..761; 764..766; 769..773; 779..794; 806..808; 809..814; 827..835; 841..843; 847..860

Beta Strand

388..394; 396..406; 417..428; 431..441; 446..449; 453..459; 461..467; 476..479; 587..595; 600..607; 613..620; 624..626; 654..659; 661..663; 665..672; 688..692; 729..731; 737..739; 800..804; 822..824

3D Structure

NMR spectroscopy (1); X-ray crystallography (38)

Domain & Motif Annotations

Domain (FT)

81..186; Ig-like C2-type 1; 197..273; Ig-like C2-type 2; 286..381; Fibronectin type-III 1; 386..484; Fibronectin type-III 2; 587..858; Protein kinase

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
AXL/UFO subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Clinical Relevance5

Disease Involvement (3)

Disease variantProto-oncogeneRetinitis pigmentosa

Related Diseases (6)

Acute myeloid leukaemia Alzheimer disease Brain cancer Mature B-cell lymphoma Myelodysplastic syndrome Solid tumour/cancer

Biomarker

Phase 1/2; Investigative; Phase 1

Drugs (6)

MK-2461 NULL NINGETINIB HESPERADIN AT9283 ONO-7475

Antibody (2)

HPA036196 HPA075622

Supporting Publications1

PMID	Title	Abstract
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available