Protein detail
MERTK
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Protein symbol MERTK | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
506..526; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
c-EykmerRP38Tyro12
Gene Description
MER proto-oncogene, tyrosine kinase
Chromosome
2
Position
111898607-112029561
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MERTK | IGF1R | P08069 | Y | 753 | phosphorylation | KEA | KEA:17570479 |
| MERTK | IGF1R | P08069 | Y | 754 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GAS6 | Q14393 | MERTK | Q12866 | Yes | Yes | No | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3InnateDBHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | HINT:8939948Cellinker:8939948Guide2Pharma:8939948HPRD:8939948Cellinker:27801848LRdb:9160883scConnect:8939948CellChatDB:27801848Cellinker:9160883SIGNOR:8939948HPMR:9160883ICELLNET:9160883LRdb:894SignaLink3:23331499connectomeDB2020:8939948CellTalkDB:9160883InnateDB:9160883SignaLink3:8939948connectomeDB2020:9160883HINT:9160883 |
| MERTK | Q12866 | VAV | P15498 | Yes | Yes | No | InnateDBHPRDSignaLink3 | SignaLink3:12920122HPRD:12920122InnateDB:12920122SignaLink3:23331499 |
| MERTK | Q12866 | MLKL | Q8NB16 | Yes | Yes | No | SIGNORPhosphoSite_ProtMapperProtMapper | SIGNOR:31230815 |
| MERTK | Q12866 | STA5B | P51692 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:16772534PhosphoSite:23980167PhosphoSite:12411494PhosphoSite:17997837PhosphoSite:18550772PhosphoSite:17822672PhosphoSite:11751923 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
999
Mass
110,249
Sequence
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
3D Structural Models
Turn
733..735
Helix
571..580; 584..586; 628..643; 679..685; 697..716; 726..728; 758..761; 764..766; 769..773; 779..794; 806..808; 809..814; 827..835; 841..843; 847..860
Beta Strand
388..394; 396..406; 417..428; 431..441; 446..449; 453..459; 461..467; 476..479; 587..595; 600..607; 613..620; 624..626; 654..659; 661..663; 665..672; 688..692; 729..731; 737..739; 800..804; 822..824
3D Structure
NMR spectroscopy (1); X-ray crystallography (38)
Domain & Motif Annotations
Domain (FT)
81..186; Ig-like C2-type 1; 197..273; Ig-like C2-type 2; 286..381; Fibronectin type-III 1; 386..484; Fibronectin type-III 2; 587..858; Protein kinase
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- AXL/UFO subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Clinical Relevance
Disease Involvement
Disease variantProto-oncogeneRetinitis pigmentosa
Related Diseases
Biomarker
Phase 1/2; Investigative; Phase 1