Protein detail

PTN13

Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)

Entry name PTN13	UniProt ID Q12923	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesEnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class (3)

Cancer-related genesEnzymesPredicted intracellular proteins

Protein Function (4)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Ensembl

ENSG00000163629

Entrez Gene Symbol

PTPN13

Gene Synonym (4)

PTP-BASPTP-BLPTP1EPTPL1

Gene Description

Protein tyrosine phosphatase non-receptor type 13

Chromosome

Position

86594315-86815171

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Cell SpecificLate primary spermatocytes

Function & Pathway8

Protein Function (4)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases
Cancer-related genes

Cellular Component (10)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04210 Apoptosis

Reactome (13)

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Canonical Pathways (3)

M3468 Naba ecm regulators
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (3)

Immune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence28

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	No	No
adhesion	adhesion	OmniPath	Yes	Yes	No	No	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No

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Regulatory Interaction Network (10)

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTN13	Q12923	EFNB1	P98172	Yes	Yes	No	HPRDWangSIGNORPDZBase	HPRD:9920925 SIGNOR:23811940 PDZBase:9920925
PTN13	Q12923	TRIP6	Q15654	Yes	No	Yes	SIGNORProtMapperDEPODHPRDHINTPDZBaseInnateDBSIGNOR_ProtMapperSPIKE_LC	ProtMapper:17591779 SIGNOR:17591779 DEPOD:17591779 InnateDB:10400701 HINT:17591779 HINT:10826496 InnateDB:17591779 HPRD:10400701 SPIKE_LC:16713569 HINT:10400701 HPRD:10826496 PDZBase:10826496
PTN13	Q12923	PDC10	Q9BUL8	Yes	No	Yes	SIGNORDEPODWangLit-BM-17SPIKE_LC	SIGNOR:17657516 DEPOD:17657516 Lit-BM-17:17657516 SPIKE_LC:17657516
PTN13	Q12923	INSR	P06213	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:15611135 ProtMapper:15611135
PTN13	Q12923	ABL1	P00519	Yes	No	Yes	REACH_ProtMapperSIGNORProtMapper	SIGNOR:28924170 ProtMapper:28924170
PTN13	Q12923	ERBB2	P04626	Yes	No	Yes	WangSIGNOR	SIGNOR:19734941
PTN13	Q12923	IKBA	P25963	Yes	Yes	Yes	WangSIGNORProtMapperDEPODHPRDHINTBioGRIDInnateDBSIGNOR_ProtMapperSPIKE_LC	BioGRID:9882613 DEPOD:11106428 HPRD:9882613 ProtMapper:11106428 HINT:9882613 SPIKE_LC:17145710 HINT:11106428 HPRD:11106428 InnateDB:11106428 SIGNOR:11106428 SPIKE_LC:14743216 DEPOD:9882613
PTN13	Q12923	SRC	P12931	Yes	Yes	Yes	NCI-PID_ProtMapperWangSIGNORProtMapper	ProtMapper:11983165 SIGNOR:19307596
PTN13	Q12923	IRS1	P35568	Yes	No	Yes	WangSIGNORDEPOD	SIGNOR:17638892 DEPOD:17638892
PTN13	Q12923	STK25	O00506	Yes	No	Yes	SIGNOR	SIGNOR:17657516

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
DDX55 MIPOL1 MRPS34 NINL PTPN13 RGS2	P41220 P82930 Q12923 Q8NHQ9 Q8TD10 Q9Y2I6	0:0:0:0:0:0	hu.MAP2
MIPOL1 PTPN13 RGS2	P41220 Q12923 Q8TD10	0:0:0	hu.MAP2
LRRC39 MIPOL1 NINL PTPN13 RGS2	P41220 Q12923 Q8TD10 Q96DD0 Q9Y2I6	0:0:0:0:0	hu.MAP2
PTPN13	Q12923	6	PDB	PDB:3lnxPDB:5glj
PTPN13 RAPGEF6	Q12923 Q8TEU7	1:1	PDB	PDB:3lny

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	R Sequencing	1	32384937

Sequence, Structure & Domains15

Sequences

Length

2,485

Mass

276,906

Sequence

MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q12923-1; Sequence=Displayed; Name=2; IsoId=Q12923-2; Sequence=VSP_000496; Name=3; IsoId=Q12923-3; Sequence=VSP_000497; Name=4; IsoId=Q12923-4; Sequence=VSP_007921

Alternative Sequence

884..1074; Missing (in isoform 2); 1056..1074; Missing (in isoform 3); 1383; T -> TVLFDK (in isoform 4)

3D Structural Models

Turn

1100..1102; 2257..2260; 2360..2363

Helix

1131..1135; 1157..1166; 1391..1393; 1405..1409; 1431..1439; 2175..2179; 2194..2209; 2212..2220; 2231..2233; 2235..2238; 2287..2289; 2290..2299; 2385..2398; 2413..2429; 2436..2444; 2454..2475

Beta Strand

1090..1097; 1105..1109; 1122..1126; 1143..1147; 1169..1177; 1366..1372; 1374..1377; 1379..1384; 1385..1387; 1388..1390; 1395..1400; 1417..1421; 1443..1450; 2188..2190; 2264..2272; 2275..2282; 2304..2307; 2311..2313; 2331..2346; 2348..2359; 2364..2373; 2404..2407; 2409..2412

3D Structure

NMR spectroscopy (7); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias

192..205; Basic and acidic residues; 270..279; Polar residues; 452..465; Polar residues; 950..971; Basic and acidic residues; 1020..1032; Polar residues; 1033..1042; Basic and acidic residues; 1243..1258; Polar residues; 1273..1288; Polar residues; 1327..1359; Polar residues; 1608..1630; Polar residues; 1736..1749; Low complexity; 1973..1996; Polar residues

Coiled Coil

469..504

Domain (FT)

3..190; KIND; 572..872; FERM; 1093..1178; PDZ 1; 1368..1452; PDZ 2; 1501..1588; PDZ 3; 1788..1868; PDZ 4; 1882..1965; PDZ 5; 2213..2467; Tyrosine-protein phosphatase

Region

186..220; Disordered; 260..283; Disordered; 433..467; Disordered; 947..975; Disordered; 995..1049; Disordered; 1227..1258; Disordered; 1273..1362; Disordered; 1608..1665; Disordered; 1715..1751; Disordered; 1971..1996; Disordered; 2408..2414; Substrate

Protein Families (2)

Protein-tyrosine phosphatase family
Non-receptor class subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Clinical Relevance6

Disease Involvement

Cancer-related genes

Drugs

ANTIESTROGEN

Antibody (2)

CAB002213 HPA065290

Interaction Protein (5)

ENSG00000065243ENSG00000107679ENSG00000108953ENSG00000164924ENSG00000170027

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
23161513	Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.	Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins.