Protein detail
ANK3
Ankyrin-3 (ANK-3) (Ankyrin-G)
Protein symbol ANK3 | UniProt ID | EVMP score 0.50 |
Frequency 7 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
Ankyrin-3 (ANK-3) (Ankyrin-G)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
Ankyrin 3
Chromosome
10
Position
60026298-60733490
Frequency
7
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificRespiratory basal cellsSingle-Nuclei Brain Specificmedium spiny neuron
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component
- GO:0005764 lysosome
- GO:0005783 endoplasmic reticulum
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005923 bicellular tight junction
- GO:0009925 basal plasma membrane
- GO:0009986 cell surface
- GO:0014704 intercalated disc
- GO:0014731 spectrin-associated cytoskeleton
- GO:0016323 basolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0030018 Z disc
- GO:0030315 T-tubule
- GO:0030425 dendrite
- GO:0031594 neuromuscular junction
- GO:0033268 node of Ranvier
- GO:0042383 sarcolemma
- GO:0043005 neuron projection
- GO:0043034 costamere
- GO:0043194 axon initial segment
- GO:0045211 postsynaptic membrane
Molecular Function
- GO:0005200 structural constituent of cytoskeleton
- GO:0005515 protein binding
- GO:0008092 cytoskeletal protein binding
- GO:0008093 cytoskeletal anchor activity
- GO:0030507 spectrin binding
- GO:0030674 protein-macromolecule adaptor activity
- GO:0044325 transmembrane transporter binding
- GO:0045296 cadherin binding
Biological Process
KEGG
Reactome
- R-hsa-418990 adherens junctions interactions
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-6807878 copi mediated anterograde transport
- R-hsa-199977 er to golgi anterograde transport
- R-hsa-445095 interaction between l1 and ankyrins
- R-hsa-373760 l1cam interactions
- R-hsa-199991 membrane trafficking
- R-hsa-9675108 nervous system development
- R-hsa-597592 post translational protein modification
- R-hsa-9768727 regulation of cdh1 posttranslational processing and trafficking to plasma membrane
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-948021 transport to the golgi and subsequent modification
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GLDN | Q6ZMI3 | ANK3 | Q12955 | Yes | Yes | No | SIGNOR | SIGNOR:19840192 |
| NRCAM | Q92823 | ANK3 | Q12955 | Yes | Yes | No | SIGNOR | SIGNOR:7961622 |
| NCHL1 | O00533 | ANK3 | Q12955 | Yes | Yes | No | SIGNOR | SIGNOR:7961622 |
| ANK3 | Q12955 | DAG1 | Q14118 | Yes | Yes | No | SIGNOR | SIGNOR:19109891 |
| ANK3 | Q12955 | SPTB2 | Q01082 | Yes | Yes | No | SIGNOR | SIGNOR:17620337 |
| ANK3 | Q12955 | GBRAP | O95166 | Yes | Yes | No | SIGNOR | SIGNOR:30504823 |
| ELAV3 | Q14576 | ANK3 | Q12955 | Yes | No | Yes | SIGNOR | SIGNOR:29614249 |
| NFASC | O94856 | ANK3 | Q12955 | Yes | Yes | No | SIGNOR | SIGNOR:7961622 |
| ANK3 | Q12955 | DMD | P11532 | Yes | Yes | No | SIGNOR | SIGNOR:19109891 |
| ANK3 | Q12955 | CADH1 | P12830 | Yes | Yes | No | SIGNOR | SIGNOR:17620337 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
4,377
Mass
480,410
Sequence
MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLSTPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSDKGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKPAIALQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTTRMVYHSPPGGEGASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQAEPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPSSAQLISDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYKDVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPEKKARPKNGKEYSSQSPTSSSPEKVLLTELLASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKAPDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDESVSVQKDFMVLKTKDEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRENHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRSESSAVSHIPVRVADERRMLSSNIPDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKESPSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPEDDTLEQVSFLDSSGKSPLTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDSNQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVKKYTFKLKEVDDEQKEKPKASAEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDLQDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHPDRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNPFPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSIPTSGECQEGTSSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHDFQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKATSPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVTTTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q12955-3; Sequence=Displayed; Name=2; IsoId=Q12955-4; Sequence=VSP_044349, VSP_044350, VSP_044351, VSP_044352, VSP_044353, VSP_044354; Name=3; IsoId=Q12955-5; Sequence=VSP_044348, VSP_044351, VSP_044352, VSP_044353, VSP_044354; Name=4; IsoId=Q12955-6; Sequence=VSP_046885, VSP_046886, VSP_044351, VSP_044352, VSP_044353, VSP_044354; Name=5; Synonyms=AnkG119, Golgi ankyrin; IsoId=Q12955-7; Sequence=VSP_053753, VSP_053754, VSP_053755, VSP_053756, VSP_053757, VSP_044351, VSP_053758, VSP_053759
Alternative Sequence
1..866; Missing (in isoform 4); 1..37; MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKK -> MASSASSSPAGTEDSAPAQGGFGSDYSRSSR (in isoform 3); 1..36; MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRK -> MSEEPKEKNAKPAHRKRKG (in isoform 2); 1..6; MAHAAS -> MNLRCD (in isoform 5); 7..385; Missing (in isoform 5); 850..870; Missing (in isoform 5); 867..872; SDVEEG -> MALPQS (in isoform 4); 872; G -> GNRCTWYKIPKVQEFTVKS (in isoform 2); 913..918; Missing (in isoform 5); 1036..1043; MVEGEGLA -> HGERRGIS (in isoform 5); 1442..1450; Missing (in isoform 2, isoform 3, isoform 4 and isoform 5); 1478..4081; Missing (in isoform 2, isoform 3 and isoform 4); 1478..1880; IERSTGATRSLPTTYSYKPFFSTRPYQSWTTAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGHAEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASALYTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSSPVKSSL -> TSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVTTKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKQGEGFKVKTKKEIRHVEKKSHS (in isoform 5); 1881..4377; Missing (in isoform 5); 4082; G -> S (in isoform 2, isoform 3 and isoform 4); 4199; G -> GYPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLS (in isoform 2, isoform 3 and isoform 4)
3D Structural Models
Helix
4089..4101; 4102..4104; 4105..4111; 4116..4125; 4130..4145; 4146..4148; 4151..4160; 4164..4171; 4173..4178
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
25..38; Basic residues; 1519..1539; Low complexity; 1977..1986; Basic and acidic residues; 2115..2136; Basic and acidic residues; 2137..2146; Polar residues; 2299..2308; Basic and acidic residues; 2390..2399; Acidic residues; 2407..2417; Polar residues; 2497..2508; Basic and acidic residues; 2588..2612; Basic and acidic residues; 2622..2631; Low complexity; 2706..2716; Polar residues; 2720..2742; Basic and acidic residues; 2796..2807; Polar residues; 3154..3186; Polar residues; 3214..3224; Polar residues; 3227..3242; Basic and acidic residues; 3335..3361; Basic and acidic residues; 3377..3402; Polar residues; 3409..3428; Acidic residues; 3465..3481; Basic and acidic residues; 3549..3575; Basic and acidic residues; 3576..3598; Low complexity; 3637..3651; Basic and acidic residues; 3654..3669; Polar residues; 3676..3713; Polar residues; 3880..3897; Polar residues; 4033..4052; Polar residues; 4053..4076; Basic and acidic residues; 4268..4277; Polar residues; 4337..4347; Basic and acidic residues; 4362..4377; Basic residues
Repeat
73..102; ANK 1; 106..135; ANK 2; 139..168; ANK 3; 172..201; ANK 4; 203..230; ANK 5; 234..263; ANK 6; 267..296; ANK 7; 300..329; ANK 8; 333..362; ANK 9; 366..395; ANK 10; 399..428; ANK 11; 432..461; ANK 12; 465..494; ANK 13; 498..527; ANK 14; 531..560; ANK 15; 564..593; ANK 16; 597..626; ANK 17; 630..659; ANK 18; 663..692; ANK 19; 696..725; ANK 20; 729..758; ANK 21; 762..791; ANK 22; 795..825; ANK 23
Domain (CC)
The tandem configuration of the two ZU5 and the UPA domains forms a structural supramodule termed ZZU. ZU5-1 mediates interaction with beta-spectrin, and the ZU5-1/UPA interface is required for ankyrin's function other than binding to spectrin (By similarity).
Domain (FT)
984..1139; ZU5 1; 1141..1288; ZU5 2; 4090..4174; Death
Region
1..44; Disordered; 1273..1407; UPA domain; 1519..1540; Disordered; 1968..1987; Disordered; 2107..2159; Disordered; 2176..2245; Disordered; 2299..2322; Disordered; 2383..2433; Disordered; 2474..2508; Disordered; 2588..2751; Disordered; 2795..2824; Disordered; 3036..3067; Disordered; 3131..3272; Disordered; 3298..3516; Disordered; 3538..3607; Disordered; 3635..3718; Disordered; 3868..3897; Disordered; 4019..4090; Disordered; 4251..4298; Disordered; 4323..4377; Disordered
Clinical Relevance
Disease Involvement
Autism spectrum disorderCancer-related genesIntellectual disability
Drugs
GR 1964292-(INDOLIN-1YL)-MELATONIN6-HYDROXYMELATONINUCM 454GR 128107S26131ICOA-13LY 156735N-[2-(2-IODO-5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDES262845-METHOXY-LUZINDOLEUCSF7447K185UCM 793EFPPEAMELATONINS22153UCSF33845-HEATUCM 7652-[125I]MELATONINS24014[125I]S70254UCM 549TASIMELTEON4P-PDOTDH97S20928[125I]DIV8806-CL-MLTRAMELTEON[125I]SD6AGOMELATINELUZINDOLECAPECITABINEISOAMYL-AGOMELATINE(HYDROXYMETHYLPHENYL)AGOMELATINEUCM1341UCM 724UCSF4226S24773CIFEABOMPPAIIK7UCM1014