Protein detail

MYO1E

Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)

Entry name MYO1E	UniProt ID Q12965	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins

Ensembl

ENSG00000157483

Entrez Gene Symbol

MYO1E

Gene Synonym (3)

HuncM-ICMGC104638MYO1C

Gene Description

Myosin IE

Chromosome

Position

59132434-59372871

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificthyroid glandCell SpecificDistal convoluted tubule cellsSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function

Function & Pathway6

Protein Function (3)

Disease related genes
Human disease related genes:Urinary system diseases:Kidney diseases
Predicted intracellular proteins

Cellular Component (11)

Page 1 of 2

Molecular Function (7)

Biological Process (3)

KEGG (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence9

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DYN1	Q05193	MYO1E	Q12965	Yes	Yes	No	SIGNOR	SIGNOR:17257598
MYO1E	Q12965	FAK1	Q05397	Yes	Yes	No	SIGNOR	SIGNOR:28348210
SYNJ1	O43426	MYO1E	Q12965	Yes	Yes	No	Lit-BM-17SIGNOR	SIGNOR:17257598 Lit-BM-17:17257598

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	R Sequencing	1	32384937

Sequence, Structure & Domains8

Sequences

Length

1,108

Mass

127,062

Sequence

MGSKGVYQYHWQSHNVKHSGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQGAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISRVSGGGTKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHIFYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVLQIVAGILHLGNISFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEKDHEEYNIGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGIMSILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAGKVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRIFQKFLQRYAILTKATWPSWQGEEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADTVTKYDRRFKGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKEVLKRKIEIERILSVSLSTMQDDIFILHEQEYDSLLESVFKTEFLSLLAKRYEEKTQKQLPLKFSNTLELKLKKENWGPWSAGGSRQVQFHQGFGDLAVLKPSNKVLQVSIGPGLPKNSRPTRRNTTQNTGYSSGTQNANYPVRAAPPPPGYHQNGVIRNQYVPYPHAPGSQRSNQKSLYTSMARPPLPRQQSTSSDRVSQTPESLDFLKVPDQGAAGVRRQTTSRPPPAGGRPKPQPKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYVTKI

Domain & Motif Annotations

Compositional Bias

933..949; Polar residues; 999..1013; Polar residues; 1035..1052; Pro residues

Domain (FT)

19..692; Myosin motor; 695..724; IQ; 730..922; TH1; 1051..1108; SH3

Region

581..591; Actin-binding; 919..966; Disordered; 993..1053; Disordered

Protein Families (2)

TRAFAC class myosin-kinesin ATPase superfamily
Myosin family

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Clinical Relevance5

Disease Involvement

Disease variant

Antibody (2)

HPA003003 HPA023886

Interaction Protein (2)

ENSG00000134996ENSG00000143799

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No abstract available