Protein detail
GRIK3
Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)
Entry name GRIK3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 3 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)
Protein Function
FDA approved drug targets:Small molecule drugs
Transmembrane
564..584; Helical; 637..657; Helical; 821..841; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization6
Cell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann gliaBlood Cell Specificnon-classical monocyteBlood Lineage SpecificmonocytesSecretome LocationSecreted to bloodSecretome FunctionEnzyme
Function & Pathway7
Protein Function
FDA approved drug targets:Small molecule drugs
Cellular Component (10)
Molecular Function (7)
- GO:0001640 adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
- GO:0004970 glutamate-gated receptor activity
- GO:0008066 glutamate receptor activity
- GO:0015277 kainate selective glutamate receptor activity
- GO:0022849 glutamate-gated calcium ion channel activity
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process (3)
KEGG (3)
Reactome (6)
- R-hsa-451326 activation of kainate receptors upon glutamate binding
- R-hsa-451306 ionotropic activity of kainate receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-500657 presynaptic function of kainate receptors
- R-hsa-112315 transmission across chemical synapses
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence41
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GLUK2-GLUK3 glutamate ionotropic kainate-type receptor complex | GRIK2GRIK3 | Q13002Q13003 | 1:1 | ComplexPortal | 1475529234706237 | |
| GLUK3 glutamate ionotropic kainate-type receptor complex | GRIK3 | Q13003 | 2 | ComplexPortal | intact:EBI-48420462 | 169580291475529234706237 |
| Glutamate_Kainate_3_4_complex | GRIK3GRIK4 | Q13003Q16099 | 1:1 | CellPhoneDBCellChatDBComplexPortal | CellPhoneDB:Glutamate_Kainate_3_4_complex | 1475529234706237 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 36550367 |
Sequence, Structure & Domains7
Sequences
Length
919
Mass
104,037
Sequence
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13003-1; Sequence=Displayed; Name=2; IsoId=Q13003-2; Sequence=VSP_056588
Alternative Sequence
856..919; RSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP -> VSLRAWSLHRMGNGDSR (in isoform 2)
Domain & Motif Annotations
Protein Families (2)
- Glutamate-gated ion channel (TC 1.A.10.1) family
- GRIK3 subfamily
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.