Protein detail

STRN3

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Entry name STRN3	UniProt ID Q13033	EVMP confidence score 0.63
Supporting publications (n) 36	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000196792

Entrez Gene Symbol

STRN3

Gene Synonym (3)

PPP2R6BS/G2NASG2NA

Gene Description

Striatin 3

Chromosome

Position

30893799-31026401

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (10)

Molecular Function (7)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence29

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (23)

23 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ATAD3B CCT2 CCT5 CCT6A CCT7 CCT8 CTRL IGBP1 PPP2R1A PPP2R2D STRN3 TCP1	P17987 P30153 P40227 P40313 P48643 P50990 P78318 P78371 Q13033 Q5T9A4 Q66LE6 Q99832	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9776
CCT2 CCT5 CCT6A CCT7 CCT8 IGBP1 PPP2R1A PPP2R2D STRN3 TCP1 TRIM36	P17987 P30153 P40227 P48643 P50990 P78318 P78371 Q13033 Q66LE6 Q99832 Q9NQ86	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6203
CCT2 CCT5 CCT6A CCT7 CCT8 CTRL IGBP1 LSM12 PPP2R2D STRN3 TCP1 UVRAG	P17987 P40227 P40313 P48643 P50990 P78318 P78371 Q13033 Q3MHD2 Q66LE6 Q99832 Q9P2Y5	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5207
CCT2 CCT5 CCT6A CCT7 CCT8 CTRL DEF8 IGBP1 PLEKHM3 PPP2R2D STRN3 TCP1	P17987 P40227 P40313 P48643 P50990 P78318 P78371 Q13033 Q66LE6 Q6ZN54 Q6ZWE6 Q99832	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3827
CCT2 CCT5 CCT6A CCT7 CCT8 CTRL HPS1 IGBP1 PPP2R2D STRN3 TCP1 VMP1	P17987 P40227 P40313 P48643 P50990 P78318 P78371 Q13033 Q66LE6 Q92902 Q96GC9 Q99832	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9117
CCT2 CCT5 CCT6A CCT7 CCT8 DTL IGBP1 PAFAH1B1 PPP2R2D STRN3 TCP1 WDR5	P17987 P40227 P43034 P48643 P50990 P61964 P78318 P78371 Q13033 Q66LE6 Q99832 Q9NZJ0	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5746
CCT2 CCT5 CCT6A CCT7 CCT8 GATA4 HDAC1 IGBP1 PAPOLG PPP2R2D STRN3 TCP1 TLE3	P17987 P40227 P43694 P48643 P50990 P78318 P78371 Q04726 Q13033 Q13547 Q66LE6 Q99832 Q9BWT3	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4308
CCT3 CCT5 CCT6A CCT7 CCT8 IGBP1 PPP2CA PPP2CB PPP2R2A PPP2R2D PPP4C STK24 STRN3 STRN4 TCP1	P17987 P40227 P48643 P49368 P50990 P60510 P62714 P63151 P67775 P78318 Q13033 Q66LE6 Q99832 Q9NRL3 Q9Y6E0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6286
CCT2 CCT3 CCT5 CCT6A CCT7 CCT8 IGBP1 PPP2CA PPP2CB PPP2R2A PPP2R2C PPP2R2D STRN3 STRN4 TCP1	P17987 P40227 P48643 P49368 P50990 P62714 P63151 P67775 P78318 P78371 Q13033 Q66LE6 Q99832 Q9NRL3 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5423
ACACA CCT2 CCT3 CCT5 CCT6A CCT8 PPP2CA PPP2CB PPP2R2A PPP2R2B PPP2R2C PPP2R2D STRN3 STRN4 TCP1	P17987 P40227 P48643 P49368 P50990 P62714 P63151 P67775 P78371 Q00005 Q13033 Q13085 Q66LE6 Q9NRL3 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8065

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingMass spectrometry	1	30550287

Sequence, Structure & Domains

Sequences

Length

797

Mass

87,209

Sequence

MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Beta; IsoId=Q13033-1; Sequence=Displayed; Name=Alpha; IsoId=Q13033-2; Sequence=VSP_006786

Alternative Sequence

330..413; Missing (in isoform Alpha)

3D Structural Models

Turn

710..712; 743..745

Helix

86..129; 175..185; 575..577

Beta Strand

471..476; 485..488; 490..498; 500..502; 504..508; 526..528; 538..541; 545..551; 555..561; 569..571; 578..583; 589..594; 601..605; 610..613; 623..625; 637..639; 647..650; 652..654; 656..659; 661..663; 668..670; 684..689; 691..700; 703..709; 717..720; 726..731; 735..742; 747..753; 758..761; 774..777; 779..781; 784..787; 793..797

3D Structure

Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

1..13; Gly residues; 23..43; Gly residues; 44..56; Low complexity; 230..241; Basic and acidic residues; 253..265; Acidic residues

Repeat

478..517; WD 1; 531..570; WD 2; 584..623; WD 3; 679..718; WD 4; 721..760; WD 5; 767..797; WD 6

Coiled Coil

77..136

Region

1..60; Disordered; 71..79; Caveolin-binding; 166..183; Calmodulin-binding; 224..278; Disordered; 313..338; Disordered

Protein Families

WD repeat striatin family

Sequence Similarities

Belongs to the WD repeat striatin family.

Clinical Relevance

Antibody (3)

HPA003392 HPA004636 CAB069925

Interaction Protein (20)

ENSG00000009790ENSG00000052723ENSG00000071054ENSG00000077063ENSG00000088986ENSG00000090372ENSG00000101109ENSG00000102572ENSG00000104695ENSG00000105568ENSG00000111790ENSG00000113575ENSG00000115694ENSG00000115808ENSG00000134602ENSG00000143079ENSG00000143093ENSG00000154310ENSG00000163681ENSG00000264364

Interaction Count

Interaction Dataset (3)

intact_biogridbiogrid_opencellintact_biogrid_opencell

Supporting Publications36

PMID	Title	Related sentences
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
38556629	Differential effects of physiological agonists on the proteome of platelet-derived extracellular vesicles.	No related sentences available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No related sentences available
39766158	A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis.	No related sentences available
39835386	Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid.	No related sentences available
39873726	Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer.	No related sentences available
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No related sentences available
39949490	CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available

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