Protein detail

STRN3

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Entry name STRN3	UniProt ID Q13033	EVMP confidence score 0.88
Supporting publications (n) 36	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000196792

Entrez Gene Symbol

STRN3

Gene Synonym (3)

PPP2R6BS/G2NASG2NA

Gene Description

Striatin 3

Chromosome

Position

30893799-31026401

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization4

Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificcerebellar inhibitory

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (10)

Molecular Function (7)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence29

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (23)

23 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 IGBP1 PPP2CA PPP2CB PPP2R2A PPP2R2D PPP4C STRN3 STRN4 TCP1	P17987 P40227 P48643 P49368 P50991 P60510 P62714 P63151 P67775 P78318 P78371 Q13033 Q66LE6 Q99832 Q9NRL3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8061
PPP2R1A STRN3	P30153 Q13033	4:4	PDB	PDB:6iur
STRN3	Q13033	2	PDB	PDB:4n6j

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingMass spectrometry	1	30550287

Sequence, Structure & Domains15

Sequences

Length

797

Mass

87,209

Sequence

MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=Beta; IsoId=Q13033-1; Sequence=Displayed; Name=Alpha; IsoId=Q13033-2; Sequence=VSP_006786

Alternative Sequence

330..413; Missing (in isoform Alpha)

3D Structural Models

Turn

710..712; 743..745

Helix

86..129; 175..185; 575..577

Beta Strand

471..476; 485..488; 490..498; 500..502; 504..508; 526..528; 538..541; 545..551; 555..561; 569..571; 578..583; 589..594; 601..605; 610..613; 623..625; 637..639; 647..650; 652..654; 656..659; 661..663; 668..670; 684..689; 691..700; 703..709; 717..720; 726..731; 735..742; 747..753; 758..761; 774..777; 779..781; 784..787; 793..797

3D Structure

Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

1..13; Gly residues; 23..43; Gly residues; 44..56; Low complexity; 230..241; Basic and acidic residues; 253..265; Acidic residues

Repeat

478..517; WD 1; 531..570; WD 2; 584..623; WD 3; 679..718; WD 4; 721..760; WD 5; 767..797; WD 6

Coiled Coil

77..136

Region

1..60; Disordered; 71..79; Caveolin-binding; 166..183; Calmodulin-binding; 224..278; Disordered; 313..338; Disordered

Protein Families

WD repeat striatin family

Sequence Similarities

Belongs to the WD repeat striatin family.

Clinical Relevance4

Antibody (3)

HPA003392 HPA004636 CAB069925

Interaction Protein (20)

ENSG00000009790ENSG00000052723ENSG00000071054ENSG00000077063ENSG00000088986ENSG00000090372ENSG00000101109ENSG00000102572ENSG00000104695ENSG00000105568ENSG00000111790ENSG00000113575ENSG00000115694ENSG00000115808ENSG00000134602ENSG00000143079ENSG00000143093ENSG00000154310ENSG00000163681ENSG00000264364

Interaction Count

Interaction Dataset (3)

intact_biogridbiogrid_opencellintact_biogrid_opencell

Supporting Publications36

PMID	Title	Abstract
32089743	Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism.	No abstract available
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
33035814	Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
34186243	A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.	No abstract available
34622320	A possible role of gas-phase electrophoretic mobility molecular analysis (nES GEMMA) in extracellular vesicle research.	No abstract available
34817906	Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform.	No abstract available
36398564	Differential ultracentrifugation enables deep plasma proteomics through enrichment of extracellular vesicles.	No abstract available
37786918	Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.	No abstract available

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