Protein detail
MKRN3
E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)
Entry name MKRN3 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
D15S9MGC88288RNF63ZFP127ZNF127
Gene Description
Makorin ring finger protein 3
Chromosome
15
Position
23565674-23630075
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Endocrine and metabolic diseases:Hypothalamus and pituitary gland diseases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
137 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P62987_P63279 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q5VVX9 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_Q13404 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:O00762_P62979 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q15819 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_P68036 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q9Y2X8 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P61077_P62987 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q8N2K1 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q9NPD8 | MKRN3 | Q13064 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster289 | LMNALMNB1LMNB2MKRN1MKRN2MKRN3 | P02545P20700Q03252Q13064Q9H000Q9UHC7 | 1:1:1:1:1:1 | Compleat | Compleat:HC912 | 22036573 |
| Ub:RING_E3 | MKRN3UBB | P0CG47Q13064 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | MKRN3UBC | P0CG48Q13064 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | MKRN3RPS27A | P62979Q13064 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | MKRN3UBA52 | P62987Q13064 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 39251709 |
Sequence, Structure & Domains
Sequences
Length
507
Mass
55,645
Sequence
MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL
3D Structural Models
Domain & Motif Annotations
Compositional Bias
1..21; Low complexity
Zinc Finger
95..122; C3H1-type 1; 238..265; C3H1-type 2; 311..365; RING-type; 394..423; C3H1-type 3
Region
1..48; Disordered; 69..89; Disordered; 126..149; Disordered; 266..293; Makorin-type Cys-His
Clinical Relevance
Disease Involvement
Disease variant
Antibody
Interaction Protein
ENSG00000072401ENSG00000107929ENSG00000198625ENSG00000229809
Interaction Count
4
Interaction Dataset
intact_biogridbiogrid_bioplex