Protein detail

PAK1

Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)

Entry name PAK1	UniProt ID Q13153	EVMP confidence score 0.40
Supporting publications (n) 4	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins

Basic Information

Protein Names

Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins

Protein Function (8)

Human disease related genes:Other diseases:Mental and behavioural disorders
Kinases:STE Ser/Thr protein kinases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
RAS pathway related proteins
Enzymes
Disease related genes

Ensembl

ENSG00000149269

Entrez Gene Symbol

PAK1

Gene Description

P21 (RAC1) activated kinase 1

Chromosome

Position

77322017-77474635

Supporting publications (n)

EVMP confidence score

0.40

Fluorescence & Localization

Tissue SpecificliverCell SpecificAstrocytesBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (8)

Human disease related genes:Other diseases:Mental and behavioural disorders
Kinases:STE Ser/Thr protein kinases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
RAS pathway related proteins
Enzymes
Disease related genes

Cellular Component (18)

Page 1 of 2

Molecular Function (10)

Biological Process (3)

KEGG (20)

Page 1 of 2

Reactome (47)

Page 1 of 5

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence198

Enzyme-Mediated Modification (92)

92 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PAK1	PPM1E	Q8WY54	S	57	dephosphorylation	SIGNOR	SIGNOR:11864573
PAK1	PPM1E	Q8WY54	T	423	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11864573
PAK1	PPM1E	Q8WY54	S	57	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:11864573
PAK1	MAPK3	P27361	T	292	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:14993270 ProtMapper:14993270
PAK1	OXSR1	O95747	T	84	phosphorylation	Sparser_ProtMapperMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEASIGNOR_ProtMapperREACH_ProtMapper	KEA:14707132 SIGNOR:14707132 ProtMapper:18676754 ProtMapper:14707132
PAK1	CDK5	Q00535	T	212	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperREACH_ProtMapper	HPRD:19664994 HPRD:19413330 KEA:11604394 ProtMapper:11604394 ProtMapper:19298660 ProtMapper:23537649 SIGNOR:11604394 HPRD:20058876 KEA:15542607 ProtMapper:12950086 ProtMapper:19036346 ProtMapper:21825040 HPRD:19664995 HPRD:11604394 KEA:12176333 KEA:17114649
PAK1	STK11	Q15831	T	109	phosphorylation	PhosphoSite_MIMPMIMPSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:20400510 SIGNOR:20400510
PAK1	CSNK2A1	P68400	S	223	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
PAK1	PRKG1	Q13976	S	21	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:10805734
PAK1	BMX	P51813	Y	153	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

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Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Receiver
receptor	receptor	OmniPath	Yes
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath
plasma_membrane	plasma_membrane	UniProt_location
plasma_membrane	plasma_membrane	OmniPath
receptor	receptor	scConnect	Yes

Regulatory Interaction Network (84)

84 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAK1	Q13153	PREX2	Q70Z35	Yes		Yes	iPTMnetSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:26438819
PAK1	Q13153	ARAF	P10398	Yes	Yes		KEGG-MEDICUSiPTMnetSIGNORProtMapperSIGNOR_ProtMapper	SIGNOR:15710605 ProtMapper:15710605
	COMPLEX:P21127_P30281	PAK1	Q13153	Yes	Yes		SIGNOR	SIGNOR:19520772
PAK1	Q13153	SNAI1	O95863	Yes	Yes		Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORphosphoELMProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAKEAphosphoELM_KEAInnateDBSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:28423359 SIGNOR:15833848 ProtMapper:29597073 ProtMapper:31275381 ProtMapper:19923321 ProtMapper:19379710 ProtMapper:19860811 KEA:15833848 ProtMapper:24556840 phosphoELM:15833848 ProtMapper:25122124 ProtMapper:22595609 InnateDB:15833848 ProtMapper:21535025 ProtMapper:25084828 ProtMapper:24168186 ProtMapper:15833848 ProtMapper:26004407 ProtMapper:25472536 PhosphoSite:15833848
PAK1	Q13153	MERL	P35240	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAdbPTMInnateDBHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperAdhesomeHPRD-phos	Adhesome:14580336 HPRD-phos:18669648 HPRD-phos:19691289 ProtMapper:27285107 ProtMapper:25893302 ProtMapper:18071304 SIGNOR:18071304 ProtMapper:19165420 HINT:11719502 ProtMapper:23162742 ProtMapper:28090172 KEA:17081983 HPRD-phos:20068231 ProtMapper:20302846 KEA:11782491 dbPTM:18669648 KEA:14981079 KEA:15378014 HPRD:14580336 ProtMapper:22567403 HINT:14580336 dbPTM:17081983 ProtMapper:31652973 HPRD-phos:11719502 ProtMapper:19651622 KEA:11719502 ProtMapper:27345717 ProtMapper:18835652 ProtMapper:11719502 ProtMapper:19691289 ProtMapper:26555075 ProtMapper:22105362 InnateDB:11719502 HPRD:11719502 HINT:21481793 Adhesome:21481793 ProtMapper:19036346 Adhesome:11719502 ProtMapper:20068231 ProtMapper:18669648 HPRD-phos:19651622
PAK1	Q13153	HACE1	Q8IYU2	Yes		Yes	Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	SIGNOR:29362425 ProtMapper:30622235 ProtMapper:29362425
CD11A	Q9UQ88	PAK1	Q13153	Yes	Yes		HPRDLit-BM-17SIGNOR	Lit-BM-17:12624090 HPRD:12624090 SIGNOR:19520772
PAK1	Q13153	ESR1	P03372	Yes	Yes		HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperHPRD-phos	ProtMapper:20179234 InnateDB:12374744 ProtMapper:24529727 ProtMapper:19557173 ProtMapper:24505617 ProtMapper:16778166 ProtMapper:26554417 HPRD-phos:12374744 ProtMapper:18755239 ProtMapper:15178330 ProtMapper:28978098 ProtMapper:22595609 phosphoELM:12374744 ProtMapper:18521086 BioGRID:16452229 ProtMapper:26944939 ProtMapper:19205871 ProtMapper:21893191 InnateDB:16452229 ProtMapper:27003261 SIGNOR:12374744 KEA:15193262 HINT:12374744 HINT:16452229 HPRD:12374744 ProtMapper:17604944 KEA:12374744 ProtMapper:25447917 ProtMapper:12374744 ProtMapper:22295213
PAK1	Q13153	CENPR	Q13352	Yes	Yes		Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:25409762 SIGNOR:18521086 ProtMapper:18521086
PAK1	Q13153	AURKA	O14965	Yes	Yes		Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperdbPTMSIGNOR_ProtMapperPhosphoSite_ProtMapper	dbPTM:16246726 ProtMapper:22864622 SIGNOR:24867643 ProtMapper:21589936 ProtMapper:24867643

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Protein Complex Composition (12)

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGEF7 PAK1	Q13153 Q14155	1:1	PDB	PDB:1zsg
	NAA11 NAA50 PAK1	Q13153 Q9BSU3 Q9GZZ1	0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	R SequencingMass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

545

Mass

60,647

Sequence

MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13153-1; Sequence=Displayed; Name=2; Synonyms=PAK1B; IsoId=Q13153-2; Sequence=VSP_017507

Alternative Sequence

518..545; HQFLKIAKPLSSLTPLIAAAKEATKNNH -> VRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS (in isoform 2)

3D Structural Models

Turn

91..94; 290..292; 463..466; 506..508

Helix

101..108; 114..119; 121..135; 250..260; 266..268; 303..305; 309..321; 352..358; 363..382; 392..394; 428..430; 433..437; 444..459; 469..479; 487..489; 492..501; 512..515; 519..523; 527..530; 531..540

Beta Strand

79..87; 95..98; 195..198; 214..219; 261..264; 270..272; 274..279; 282..289; 295..302; 330..336; 339..345; 349..351; 395..397; 403..405; 408..410; 416..418

3D Structure

NMR spectroscopy (1); X-ray crystallography (36)

Domain & Motif Annotations

Compositional Bias

68..77; Basic and acidic residues; 174..184; Acidic residues; 220..231; Polar residues

Domain (FT)

75..88; CRIB; 270..521; Protein kinase

Region

1..77; Disordered; 70..140; Autoregulatory region; 75..105; GTPase-binding; 159..198; Disordered; 211..251; Disordered

Protein Families (3)

Protein kinase superfamily
STE Ser/Thr protein kinase family
STE20 subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Clinical Relevance

Disease Involvement (3)

Disease variantEpilepsyIntellectual disability

Related Diseases (2)

Epilepsy Intellectual disability

Drugs (10)

CENISERTIB PF-562271 BARASERTIB-HQPA NVP-TAE684 MLN-8054 LAUROGUADINE TOZASERTIB ILORASERTIB TAMATINIB RG-1530

Antibody (2)

HPA003565 CAB005312

Interaction Protein (12)

ENSG00000070831ENSG00000071051ENSG00000088986ENSG00000102606ENSG00000106683ENSG00000108262ENSG00000116574ENSG00000126785ENSG00000129675ENSG00000136238ENSG00000139436ENSG00000146648

Interaction Count

Interaction Dataset (2)

intact_biogridintact_biogrid_opencell

Supporting Publications4

PMID	Title	Related sentences
30301952	A position on vision.	No related sentences available
38343172	Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro- and anti-inflammatory proteomic profiles.	No related sentences available
40222457	Proteome alterations in peripheral immune cells of DLBCL patients and evidence of cancer extracellular vesicles involvement.	No related sentences available
40595564	Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.	No related sentences available