Protein detail

S13A2

Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)

Protein symbol S13A2	UniProt ID Q13183	EVMP score 0.38
Frequency	Transmembrane count 12	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)

Protein Class

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

13..33; Helical; 53..73; Helical; 86..106; Helical; 114..134; Helical; 221..241; Helical; 274..294; Helical; 324..344; Helical; 371..391; Helical; 450..470; Helical; 482..502; Helical; 511..531; Helical; 545..565; Helical

Transmembrane Count

Ensembl

ENSG00000007216

Entrez Gene Symbol

SLC13A2

Gene Synonym

NaDC-1

Gene Description

Solute carrier family 13 member 2

Chromosome

Position

28473293-28497781

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificliverCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
solute_carrier	transporter	Almen2009	No	Yes	No	No	No
slc13	transporter	Surfaceome	No	Yes	No	No	No
slc	transporter	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	AREL1 DAGLA GCNT1 KLK3 PDZD8 PNPLA5 SLC13A2 UBA52 ZNRF4	O15033 P07288 P62987 Q02742 Q13183 Q7Z6Z6 Q8NEN9 Q8WWF5 Q9Y4D2	0:0:0:0:0:0:0:0:0	hu.MAP2
	SLC13A2	Q13183	2	PDB	PDB:8w6dPDB:8w6cPDB:8w6g

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	R SequencingMass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

592

Mass

64,410

Sequence

MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13183-1; Sequence=Displayed; Name=2; IsoId=Q13183-2; Sequence=VSP_046426, VSP_046427; Name=3; IsoId=Q13183-3; Sequence=VSP_046427

Alternative Sequence

1..44; Missing (in isoform 2); 77; E -> EIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQ (in isoform 2 and isoform 3)

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Compositional Bias

165..177; Polar residues

Region

165..185; Disordered

Protein Families

SLC13A/DASS transporter (TC 2.A.47) family
NADC subfamily

Sequence Similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.

Clinical Relevance

Antibody

HPA014963