Protein detail
S13A2
Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)
Protein symbol S13A2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
13..33; Helical; 53..73; Helical; 86..106; Helical; 114..134; Helical; 221..241; Helical; 274..294; Helical; 324..344; Helical; 371..391; Helical; 450..470; Helical; 482..502; Helical; 511..531; Helical; 545..565; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
NaDC-1
Gene Description
Solute carrier family 13 member 2
Chromosome
17
Position
28473293-28497781
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificliverCell SpecificAstrocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0015138 fumarate transmembrane transporter activity
- GO:0015139 alpha-ketoglutarate transmembrane transporter activity
- GO:0015141 succinate transmembrane transporter activity
- GO:0015361 low-affinity sodium:dicarboxylate symporter activity
- GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 3 of 3Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | R SequencingMass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
592
Mass
64,410
Sequence
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13183-1; Sequence=Displayed; Name=2; IsoId=Q13183-2; Sequence=VSP_046426, VSP_046427; Name=3; IsoId=Q13183-3; Sequence=VSP_046427
Alternative Sequence
1..44; Missing (in isoform 2); 77; E -> EIIQRPFPSSFESPGECQSVGMSVTASHNLGGTVGDSRVFPPLSHVSTCQ (in isoform 2 and isoform 3)
3D Structural Models
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Compositional Bias
165..177; Polar residues
Region
165..185; Disordered
Protein Families
- SLC13A/DASS transporter (TC 2.A.47) family
- NADC subfamily
Sequence Similarities
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Clinical Relevance
Antibody