Protein detail
PD2R
Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
Entry name PD2R | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)
Protein Class (5)
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
22..42; Helical; Name=1; 60..80; Helical; Name=2; 108..128; Helical; Name=3; 151..171; Helical; Name=4; 196..216; Helical; Name=5; 263..283; Helical; Name=6; 311..331; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
DPDP1PTGDR1
Gene Description
Prostaglandin D2 receptor
Chromosome
14
Position
52267698-52276724
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (4)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (6)
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence59
Ligand-Receptor Signaling (53)
53 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | Yes | Yes | |||
| receptor | receptor | HPMR | Yes | Yes | |||
| receptor | receptor | CellChatDB | Yes | Yes | |||
| receptor | receptor | CellTalkDB | Yes | Yes | |||
| receptor | receptor | Surfaceome | Yes | Yes | |||
| receptor | receptor | Ramilowski2015 | Yes | Yes | |||
| gpcr | receptor | DGIdb | Yes | Yes | |||
| receptor | receptor | LRdb | Yes | Yes | |||
| receptor | receptor | Baccin2019 | Yes | Yes | |||
| gpcr | receptor | Almen2009 | Yes | Yes |
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Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PD2R | Q13258 | GNAL | P38405 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| PD2R | Q13258 | GNAS3 | O95467 | Yes | Yes | HPRDSIGNOR | HPRD:12672054SIGNOR:31160049 | |
| PD2R | Q13258 | ALEX | P84996 | Yes | Yes | HPRDSIGNOR | HPRD:12672054SIGNOR:31160049 | |
| PD2R | Q13258 | GNAS2 | P63092 | Yes | Yes | HPRDSIGNOR | HPRD:12672054SIGNOR:31160049 | |
| PD2R | Q13258 | GNAS1 | Q5JWF2 | Yes | Yes | HPRDSIGNOR | HPRD:12672054SIGNOR:31160049 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingFlow cytometry | 1 | 38321535 |
Sequence, Structure & Domains
Sequences
Length
359
Mass
40,271
Sequence
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13258-1; Sequence=Displayed; Name=2; IsoId=Q13258-2; Sequence=VSP_055141, VSP_055142
Alternative Sequence
283..296; YRAYYGAFKDVKEK -> AFVPGVPAKTPGSR (in isoform 2); 297..359; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement (2)
AsthmaFDA approved drug targets
Related Diseases (12)
Biomarker
Phase 2; Discontinued in Phase 3; Phase 3; Phase 4; Phase 1; Investigative; Discontinued in Phase 2; Clinical trial
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000125447
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No related sentences available |