Protein detail

PD2R

Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)

Entry name PD2R	UniProt ID Q13258	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor)

Protein Class (5)

Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins

Protein Function (4)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Disease related genes
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

22..42; Helical; Name=1; 60..80; Helical; Name=2; 108..128; Helical; Name=3; 151..171; Helical; Name=4; 196..216; Helical; Name=5; 263..283; Helical; Name=6; 311..331; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000168229

Entrez Gene Symbol

PTGDR

Gene Synonym (3)

DPDP1PTGDR1

Gene Description

Prostaglandin D2 receptor

Chromosome

Position

52267698-52276724

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway7

Protein Function (4)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Disease related genes
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04080 Neuroactive ligand-receptor interaction

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence59

Ligand-Receptor Signaling (53)

53 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
gpcr	receptor	Almen2009	No	Yes	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PD2R	Q13258	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PD2R	Q13258	GNAS3	O95467	Yes	Yes	No	HPRDSIGNOR	HPRD:12672054 SIGNOR:31160049
PD2R	Q13258	ALEX	P84996	Yes	Yes	No	HPRDSIGNOR	HPRD:12672054 SIGNOR:31160049
PD2R	Q13258	GNAS2	P63092	Yes	Yes	No	HPRDSIGNOR	HPRD:12672054 SIGNOR:31160049
PD2R	Q13258	GNAS1	Q5JWF2	Yes	Yes	No	HPRDSIGNOR	HPRD:12672054 SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blottingFlow cytometry	1	38321535

Sequence, Structure & Domains8

Sequences

Length

359

Mass

40,271

Sequence

MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13258-1; Sequence=Displayed; Name=2; IsoId=Q13258-2; Sequence=VSP_055141, VSP_055142

Alternative Sequence

283..296; YRAYYGAFKDVKEK -> AFVPGVPAKTPGSR (in isoform 2); 297..359; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance9

Disease Involvement (2)

AsthmaFDA approved drug targets

Related Diseases (12)

Allergic/hypersensitivity disorder Arterial occlusive disease Asthma Atopic eczema Coronary atherosclerosis Diabetes mellitus Dyslipidemia Pain Rheumatoid arthritis Solid tumour/cancer Thrombosis Vasomotor/allergic rhinitis

Biomarker

Phase 2; Discontinued in Phase 3; Phase 3; Phase 4; Phase 1; Investigative; Discontinued in Phase 2; Clinical trial

Drug Targets

FDA approved drug targets

Drugs (9)

DINOPROST LAROPIPRANT VIDUPIPRANT FEVIPIPRANT SETIPIPRANT DEXAMETHASONE ASAPIPRANT MK-1029 AM-461

Antibody (2)

HPA046586 HPA049668

Interaction Protein

ENSG00000125447

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications4

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available