Protein detail

KCAB2

Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)

Protein symbol KCAB2	UniProt ID Q13303	EVMP score 0.38
Frequency	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000069424

Entrez Gene Symbol

KCNAB2

Gene Synonym

AKR6A5HKvbeta2.1HKvbeta2.2KCNA2B

Gene Description

Potassium voltage-gated channel subfamily A regulatory beta subunit 2

Chromosome

Position

5990927-6101193

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificLactotrophs

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
KCNAB2	CDK2	P24941	S	31	phosphorylation	PhosphoSite
KCNAB2	CDK5	Q00535	S	31	phosphorylation	PhosphoSite
KCNAB2	PRKCA	P17252	S	266	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
KCNAB2	PRKCA	P17252	S	314	phosphorylation	MIMPPhosphoSite_MIMP
KCNAB2	GSK3B	P49841	S	20	phosphorylation	KEA	KEA:17570479
KCNAB2	MAPK10	P53779	S	20	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCA	P17252	KCAB2	Q13303	Yes	No	No	PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:12604245

Protein Complex Composition

3 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Potassium channel complex (KCNA1KCNA2KCNAB2)	KCNA1 KCNA2 KCNAB2	P16389 Q09470 Q13303	0:0:0	CORUM	CORUM:7389	11086297
	KCNA3 KCNAB2	P22001 Q13303	4:4	PDB	PDB:7wf3PDB:7ej1PDB:7ej2PDB:7wf4
	KCNAB2 PREP	P48147 Q13303	0:0	hu.MAP

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

367

Mass

41,000

Sequence

MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=KvB2.1; IsoId=Q13303-1; Sequence=Displayed; Name=2; Synonyms=KvB2.2; IsoId=Q13303-2; Sequence=VSP_001054; Name=3; IsoId=Q13303-3; Sequence=VSP_041189, VSP_041190; Name=4; IsoId=Q13303-4; Sequence=VSP_044311; Name=5; IsoId=Q13303-5; Sequence=VSP_057282

Alternative Sequence

1..67; Missing (in isoform 4); 1..38; MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQF -> MLSMTYSESLRSVSSRCHSEWALHPVRQTDTLELQRLREVRAAAQARNMESFLRMHGLSLDGCTAQRTGMK (in isoform 3); 26..39; Missing (in isoform 2); 167; E -> EGDPFSSSKSRTFIIE (in isoform 3); 340..367; LPKLSSSIIHEIDSILGNKPYSKKDYRS -> RVRGPAGQRAHPSPSPVQCILPGSSCVPGSVLGTQDAPVNHQSCAPGELAFQQEQT (in isoform 5)

3D Structural Models

Turn

253..257

Helix

59..63; 66..78; 90..93; 94..106; 110..112; 126..128; 133..147; 166..178; 192..205; 223..226; 228..236; 247..252; 264..266; 271..277; 280..299; 303..313; 327..334; 336..339; 340..342; 345..355

Beta Strand

39..42; 48..55; 83..85; 87..89; 114..121; 129..131; 152..159; 162..164; 181..189; 212..216; 218..220; 239..243; 267..269; 314..316; 317..322

3D Structure

Electron microscopy (4); X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)

In contrast to KCNAB1, the shorter N-terminal domain of KCNAB2 cannot mediate closure of delayed rectifier potassium channels by physically obstructing the pore.

Protein Families

Shaker potassium channel beta subunit family

Sequence Similarities

Belongs to the shaker potassium channel beta subunit family.

Clinical Relevance

Antibody

CAB001975

Interaction Protein

ENSG00000177301

Interaction Count

Interaction Dataset

intact_biogrid