Protein detail
PTK7
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Entry name PTK7 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Protein Class
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Kinases:Tyr protein kinases
- Enzymes
- Predicted secreted proteins
- Predicted intracellular proteins
Transmembrane
705..725; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CCK4
Gene Description
Protein tyrosine kinase 7 (inactive)
Chromosome
6
Position
43076307-43161719
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Kinases:Tyr protein kinases
- Enzymes
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| kinase | receptor | Almen2009 | No | Yes | Yes | Yes | No |
| receptor_tyrosine_kinases_rtk | receptor | HPMR | No | Yes | Yes | Yes | No |
| vegf_pdgf | receptor | HPMR | No | Yes | Yes | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTK7 | Q13308 | CTNB1 | P35222 | Yes | No | Yes | Lit-BM-17SIGNOR | SIGNOR:23151663Lit-BM-17:21132015 |
| RACK1 | P63244 | PTK7 | Q13308 | Yes | Yes | No | SIGNOR | SIGNOR:21350015 |
| SRC | P12931 | PTK7 | Q13308 | Yes | Yes | No | SIGNOR | SIGNOR:24703874 |
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HSPA13PEX10PEX11APEX11BPEX11GPEX13PEX14PEX19PEX3PEX5PEX7PTK7UBC | O00628O60683O75192O75381O96011P0CG48P40855P48723P50542P56589Q13308Q92968Q96HA9 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4893 | ||
| PTK7 | Q13308 | 3 | PDB | PDB:6vg3 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37432984 |
Sequence, Structure & Domains
Sequences
Length
1,070
Mass
118,392
Sequence
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=PTK7-1; IsoId=Q13308-1; Sequence=Displayed; Name=2; Synonyms=PTK7-2; IsoId=Q13308-2; Sequence=VSP_037182; Name=3; Synonyms=PTK7-3; IsoId=Q13308-3; Sequence=VSP_037181; Name=4; Synonyms=PTK7-4; IsoId=Q13308-4; Sequence=VSP_037183; Name=5; Synonyms=PTK7-5; IsoId=Q13308-5; Sequence=VSP_037184, VSP_037185; Name=6; IsoId=Q13308-6; Sequence=VSP_044775
Alternative Sequence
1..26; MGAARGSPARPRRLPLLSVLLLPLLG -> MGSFLSGEKRPSAPTVGSAMEKKEFPTPPGRVGP (in isoform 6); 410..540; TVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD -> N (in isoform 3); 500..539; Missing (in isoform 2); 627..682; Missing (in isoform 4); 804..816; KSEFGEVFLAKAQ -> RPQAVPEDFQEQG (in isoform 5); 817..1070; Missing (in isoform 5)
3D Structural Models
Turn
952..956; 1006..1009
Helix
793..795; 837..852; 883..890; 904..923; 933..935; 957..959; 970..972; 975..980; 985..1000; 1012..1020; 1034..1043; 1048..1050; 1054..1062
Beta Strand
796..804; 806..816; 823..832; 861..865; 867..876; 879..882; 936..938; 944..946; 961..963; 966..968
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (CC)
The protein kinase domain is predicted to be catalytically inactive.
Domain (FT)
31..120; Ig-like C2-type 1; 128..218; Ig-like C2-type 2; 225..317; Ig-like C2-type 3; 309..407; Ig-like C2-type 4; 412..497; Ig-like C2-type 5; 503..586; Ig-like C2-type 6; 578..680; Ig-like C2-type 7; 796..1066; Protein kinase; inactive
Region
736..759; Disordered; 773..793; Disordered; 794..1070; Interaction with CTNNB1
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Insulin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.