Protein detail
CRFR2
Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)
Protein symbol CRFR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2)
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Predicted secreted proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
109..139; Helical; Name=1; 147..171; Helical; Name=2; 186..214; Helical; Name=3; 222..249; Helical; Name=4; 266..291; Helical; Name=5; 303..327; Helical; Name=6; 335..364; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificNeutrophil progenitorsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Predicted secreted proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | Yes | Yes | No |
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | Yes | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | Yes | Yes | No |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CRF | P06850 | CRFR2 | Q13324 | Yes | Yes | No | iTALKKEGG-MEDICUSGuide2Pharma_LRdbSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | connectomeDB2020:11123370Guide2Pharma:11123370LRdb:8536644LRdb:8243338connectomeDB2020:8243338HPMR:8536644SIGNOR:23504413LRdb:11123370Cellinker:8243338HPRD:8243338connectomeDB2020:8536644scConnect:11123370CellTalkDB:11123370Cellinker:11123370Cellinker:8536644 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 40784529 |
Sequence, Structure & Domains
Sequences
Length
411
Mass
47,688
Sequence
MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=CRF2-alpha; IsoId=Q13324-1; Sequence=Displayed; Name=CRF2-beta; IsoId=Q13324-2; Sequence=VSP_001999; Name=CRF2-gamma; IsoId=Q13324-3; Sequence=VSP_002000; Name=D; IsoId=Q13324-4; Sequence=VSP_053565; Name=E; IsoId=Q13324-5; Sequence=VSP_053566; Name=F; IsoId=Q13324-6; Sequence=VSP_053567; Name=desQ; IsoId=Q13324-7; Sequence=VSP_053564
Alternative Sequence
1..34; MDAALLHSLLEANCSLALAEELLLDGWGPPLDPE -> MRGPSGPPGLLYVPHLLLCLLCLLPPPLQYAAGQSQMPKDQPLWALLEQYCHTIMTLTNLS (in isoform CRF2-beta); 1..34; MDAALLHSLLEANCSLALAEELLLDGWGPPLDPE -> MGREPWPEDRDLGFPQLFCQ (in isoform CRF2-gamma); 106; Missing (in isoform desQ); 366..411; VRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV -> SWVSKEAQAAGPHGREKPEQRW (in isoform D); 366..411; VRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV -> GLEPV (in isoform E); 367..411; Missing (in isoform F)
3D Structural Models
Turn
232..236; 316..320
Helix
3..27; 103..105; 111..140; 147..170; 174..178; 182..213; 219..221; 224..231; 237..247; 253..255; 266..297; 301..315; 321..324; 334..349; 351..360; 364..381
Beta Strand
59..63; 66..68; 71..73; 77..83; 87..89
3D Structure
Electron microscopy (3); X-ray crystallography (3)
Domain & Motif Annotations
Domain (CC)
The transmembrane domain is composed of seven transmembrane helices that are arranged in V-shape. Transmembrane helix 7 assumes a sharply kinked structure (By similarity).; DOMAIN: The uncleaved pseudo signal peptide prevents receptor's oligomerization and coupling to G(i) subunits. It is also responsible for the rather low receptor localization at the plasma membrane (PubMed:22689579).
Protein Families
G-protein coupled receptor 2 family
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family.