Protein detail
PTPRS
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Entry name PTPRS | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Protein Function
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Transmembrane
1283..1303; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
Cellular Component
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0030424 axon
- GO:0030426 growth cone
- GO:0030672 synaptic vesicle membrane
- GO:0042734 presynaptic membrane
- GO:0043204 perikaryon
- GO:0070062 extracellular exosome
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098839 postsynaptic density membrane
- GO:0098978 glutamatergic synapse
Molecular Function
Biological Process
Reactome
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1474244 extracellular matrix organization
- R-hsa-112316 neuronal system
- R-hsa-6794362 protein protein interactions at synapses
- R-hsa-388844 receptor type tyrosine protein phosphatases
- R-hsa-9034015 signaling by ntrk3 trkc
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-8849932 synaptic adhesion like molecules
Canonical Pathways
- M67 Pid arf6 trafficking pathway
- M8 Pid endothelin pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | Yes | Yes | No |
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | No |
| receptor_tyrosine_phosphatase | receptor | Almen2009 | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRS | Q13332 | EGFR | P00533 | Yes | No | Yes | SIGNORProtMapperDEPODHPRDREACH_ProtMapper | DEPOD:15522239DEPOD:10435588HPRD:10435588SIGNOR:12018405ProtMapper:29915291 |
| LRFN5 | Q96NI6 | PTPRS | Q13332 | Yes | Yes | No | CellChatDBCellPhoneDBICELLNETSIGNORWojtowicz2020 | SIGNOR:27225731CellChatDB:29674953CellChatDB:23916315ICELLNET:32822567 |
| PGBM | P98160 | PTPRS | Q13332 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020CellinkerWangLRdbHPMR_talklr | SIGNOR:11865065connectomeDB2020:11865065CellTalkDB:11865065HPMR:11865065LRdb:11865065Cellinker:11865065 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GRK2PFKMPTPRFPTPRS | P08237P10586P25098Q13332 | 0:0:0:0 | hu.MAP | |||
| ACVR1BPTPRFPTPRS | P10586P36896Q13332 | 0:0:0 | hu.MAP | |||
| FEZ1PTNPTPRS | P21246Q13332Q99689 | 1:1:1 | CompleatCFinder | Compleat:HC8825 | ||
| GIPC2NTRK3PTPRSSH3BP4 | Q13332Q16288Q8TF65Q9P0V3 | 0:0:0:0 | hu.MAP2 | |||
| NTRK3PTPRSSH3BP4 | Q13332Q16288Q9P0V3 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Small R sequencing (Illumi HiSeq 2000 (Solexa)Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
1,948
Mass
217,041
Sequence
MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Alternative Products
Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=PTPS; IsoId=Q13332-1; Sequence=Displayed; Name=PTPS-MEA; IsoId=Q13332-2; Sequence=VSP_050021; Name=PTPS-MEB; IsoId=Q13332-3; Sequence=VSP_050022, VSP_050026, VSP_050027; Name=PTPS-MEC; IsoId=Q13332-4; Sequence=VSP_050024; Name=PTPS-F4-7; IsoId=Q13332-5; Sequence=VSP_050023, VSP_050025; Name=2; IsoId=Q13332-6; Sequence=VSP_050021, VSP_050022, VSP_050024, VSP_050026, VSP_050027; Name=3; IsoId=Q13332-7; Sequence=VSP_050021, VSP_050022, VSP_050023, VSP_050025, VSP_050026, VSP_050027
Alternative Sequence
190..198; Missing (in isoform PTPS-MEA, isoform 2 and isoform 3); 236..239; Missing (in isoform PTPS-MEB, isoform 2 and isoform 3); 617..1034; Missing (in isoform PTPS-F4-7 and isoform 3); 784..792; Missing (in isoform PTPS-MEC and isoform 2); 1035; V -> I (in isoform PTPS-F4-7 and isoform 3); 1350..1365; Missing (in isoform PTPS-MEB, isoform 2 and isoform 3); 1366; S -> G (in isoform PTPS-MEB, isoform 2 and isoform 3)
3D Structural Models
Turn
69..71; 98..101; 180..182; 563..565; 1414..1416; 1442..1445; 1703..1705; 1718..1720; 1728..1730; 1731..1734; 1828..1830; 1916..1918
Helix
84..86; 127..129; 177..179; 208..210; 472..474; 1375..1377; 1378..1398; 1409..1412; 1417..1419; 1429..1431; 1469..1471; 1472..1481; 1565..1577; 1595..1612; 1617..1625; 1635..1650; 1658..1660; 1661..1668; 1679..1685; 1698..1701; 1706..1708; 1758..1760; 1761..1770; 1854..1869; 1885..1903; 1908..1915; 1926..1941
Beta Strand
31..37; 42..45; 50..60; 63..68; 75..83; 88..93; 103..111; 114..125; 136..139; 144..147; 152..154; 157..159; 165..170; 183..186; 201..205; 212..220; 223..226; 230..235; 243..249; 254..256; 262..272; 275..280; 288..290; 293..300; 307..315; 318..327; 339..343; 348..351; 361..370; 377..382; 384..389; 397..405; 410..413; 417..420; 431..441; 443..448; 457..466; 475..479; 482..488; 496..507; 516..524; 529..537; 540..546; 554..562; 569..573; 577..581; 589..598; 601..605; 609..612; 1432..1434; 1446..1454; 1457..1464; 1486..1489; 1493..1495; 1507..1513; 1516..1525; 1527..1538; 1545..1552; 1557..1560; 1562..1564; 1585..1594; 1676..1678; 1737..1741; 1744..1746; 1750..1753; 1775..1778; 1782..1784; 1796..1798; 1800..1802; 1805..1814; 1816..1827; 1833..1841; 1846..1848; 1876..1884; 1904..1906
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
701..713; Low complexity; 1311..1321; Basic and acidic residues; 1331..1340; Basic and acidic residues
Domain (FT)
33..123; Ig-like C2-type 1; 135..233; Ig-like C2-type 2; 245..327; Ig-like C2-type 3; 334..424; Fibronectin type-III 1; 429..523; Fibronectin type-III 2; 527..616; Fibronectin type-III 3; 621..718; Fibronectin type-III 4; 723..831; Fibronectin type-III 5; 832..930; Fibronectin type-III 6; 931..1033; Fibronectin type-III 7; 1036..1120; Fibronectin type-III 8; 1393..1648; Tyrosine-protein phosphatase 1; 1680..1939; Tyrosine-protein phosphatase 2
Region
68..72; Important for binding to glycosaminoglycan chains; 700..724; Disordered; 1311..1340; Disordered
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 2A subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000054356
Interaction Count
1
Interaction Dataset
intact_biogrid