Protein detail

UT1

Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)

Entry name UT1	UniProt ID Q13336	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 9	Protein classification Blood group antigen proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)

Protein Class (5)

Blood group antigen proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (3)

Blood group antigen proteins
Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

53..73; Helical; 91..110; Helical; 116..136; Helical; 143..163; Helical; 173..193; Helical; 242..262; Helical; 281..301; Helical; 310..330; Helical; 333..353; Helical

Transmembrane Count

Ensembl

ENSG00000141469

Entrez Gene Symbol

SLC14A1

Gene Synonym (4)

HsT1341JKRACH1RACH2

Gene Description

Solute carrier family 14 member 1 (Kidd blood group)

Chromosome

Position

45687025-45752520

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificependymal cellSecretome LocationIntracellular and membraneSecretome FunctionEnzyme

Function & Pathway6

Protein Function (3)

Blood group antigen proteins
Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Reactome (3)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC14A1	Q13336	3	PDB	PDB:8xdfPDB:8blp

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	1	38207106

Sequence, Structure & Domains11

Sequences

Length

389

Mass

42,528

Sequence

MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13336-1; Sequence=Displayed; Name=2; IsoId=Q13336-2; Sequence=VSP_041573

Alternative Sequence

1; M -> MNGRSLIGGAGDARHGPVWKDPFGTKAGDAARRGIARLSLALADGSQEQEPEEEIAM (in isoform 2)

3D Structural Models

Turn

119..123; 283..287; 298..300; 332..334

Helix

32..38; 43..49; 54..67; 68..70; 75..88; 90..109; 114..118; 124..136; 144..146; 147..168; 169..171; 178..191; 214..216; 219..231; 232..234; 239..252; 254..273; 278..282; 288..297; 306..331; 340..351; 364..366; 370..384

Beta Strand

137..139; 196..198

3D Structure

Electron microscopy (3); X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Urea transporter family

Sequence Similarities

Belongs to the urea transporter family.

Clinical Relevance5

Drug Targets

Literature-reported target

Antibody (2)

HPA059570 HPA077233

Interaction Protein (3)

ENSG00000132589ENSG00000137312ENSG00000185344

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications1

PMID	Title	Abstract
31737616	Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model.	No abstract available