Protein detail
UT1
Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)
Entry name UT1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 9 | Protein classification Blood group antigen proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Urea transporter 1 (Solute carrier family 14 member 1) (Urea transporter, erythrocyte)
Protein Class
Blood group antigen proteinsMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Blood group antigen proteins
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
53..73; Helical; 91..110; Helical; 116..136; Helical; 143..163; Helical; 173..193; Helical; 242..262; Helical; 281..301; Helical; 310..330; Helical; 333..353; Helical
Transmembrane Count
9
Ensembl
Entrez Gene Symbol
Gene Synonym
HsT1341JKRACH1RACH2
Gene Description
Solute carrier family 14 member 1 (Kidd blood group)
Chromosome
18
Position
45687025-45752520
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificintestineCell SpecificEnterocytesSingle-Nuclei Brain Specificependymal cellSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Blood group antigen proteins
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [LTQ-FT Ultra] | 1 | 38207106 |
Sequence, Structure & Domains
Sequences
Length
389
Mass
42,528
Sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13336-1; Sequence=Displayed; Name=2; IsoId=Q13336-2; Sequence=VSP_041573
Alternative Sequence
1; M -> MNGRSLIGGAGDARHGPVWKDPFGTKAGDAARRGIARLSLALADGSQEQEPEEEIAM (in isoform 2)
3D Structural Models
Turn
119..123; 283..287; 298..300; 332..334
Helix
32..38; 43..49; 54..67; 68..70; 75..88; 90..109; 114..118; 124..136; 144..146; 147..168; 169..171; 178..191; 214..216; 219..231; 232..234; 239..252; 254..273; 278..282; 288..297; 306..331; 340..351; 364..366; 370..384
Beta Strand
137..139; 196..198
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
Urea transporter family
Sequence Similarities
Belongs to the urea transporter family.