Protein detail
PLD1
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)
Entry name PLD1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)
Protein Class (8)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteins
Protein Function (7)
- Predicted intracellular proteins
- Potential drug targets
- RAS pathway related proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
Phospholipase D1
Chromosome
3
Position
171600404-171810950
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificCorticotrophsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- Potential drug targets
- RAS pathway related proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component (15)
- GO:0000139 Golgi membrane
- GO:0005765 lysosomal membrane
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0030139 endocytic vesicle
- GO:0031410 cytoplasmic vesicle
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Molecular Function (3)
Biological Process (3)
KEGG (16)
- hsa00564 Glycerophospholipid metabolism
- KEGG:hsa00565 Ether lipid metabolism
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04071 Sphingolipid signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa04724 Glutamatergic synapse
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Reactome (15)
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-168249 innate immune system
- R-hsa-556833 metabolism of lipids
- R-hsa-6798695 neutrophil degranulation
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
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Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence31
Enzyme-Mediated Modification (13)
13 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PLD1 | CSNK2A1 | P68400 | S | 611 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PLD1 | CSNK2A1 | P68400 | S | 610 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PLD1 | RPS6KA3 | P51812 | T | 147 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:26437780 |
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Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellTalkDB | Yes | ||||
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHOA | P61586 | PLD1 | Q13393 | Yes | Yes | WangAdhesomeSIGNORHPRDHINTSPIKE_LCSPIKE | HINT:11311142HPRD:11311142HPRD:12593858Adhesome:11311142SPIKE_LC:11311142HINT:12593858SPIKE_LC:12593858HPRD:9565577Adhesome:12593858SPIKE:11311142Adhesome:9565577SIGNOR:11102529SPIKE:12593858 | |
| KPCA | P17252 | PLD1 | Q13393 | Yes | Yes | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEANCI-PID_ProtMapperHPRDWangNetworKIN_KEAHPRD-phosPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperAdhesomeNetPathSPIKE_LCSPIKE | HPRD:10441128HPRD-phos:10441128Adhesome:10441128NetPath:11459228HPRD:12839565Adhesome:12839565SPIKE_LC:12429840SIGNOR:10441128Adhesome:1559964ProtMapper:10441128Adhesome:11042115KEA:17570479ProtMapper:22609963ProtMapper:9989263KEA:10441128SPIKE:12429840ProtMapper:12429840 | |
| RHEB | Q15382 | PLD1 | Q13393 | Yes | Yes | InnateDBWangSIGNOR | InnateDB:18550814SIGNOR:18550814 | |
| COMPLEX:O43741_P54619_P54646_Q13131_Q9UGI9_Q9UGJ0_Q9Y478 | PLD1 | Q13393 | Yes | Yes | SIGNOR | SIGNOR:20231899 | ||
| AAPK2 | P54646 | PLD1 | Q13393 | Yes | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:20231899ProtMapper:20231899 | |
| CSK21 | P68400 | PLD1 | Q13393 | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:11171116 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| MAPKAP1MLST8MTORPLD1RHEBRICTORRPS6KB1RPTORSGK1SLC39A1UBC | O00141P0CG48P23443P42345Q13393Q15382Q6R327Q8N122Q9BPZ7Q9BVC4Q9NY26 | 1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6845 | ||
| PNMA8ARARARARBRARGZPLD1 | P10276P10826P13631Q86V59Q8TCW7 | 0:0:0:0:0 | hu.MAP2 | |||
| PLD1 | Q13393 | 6 | PDB | PDB:6ohr |
Sequence, Structure & Domains
Sequences
Length
1,074
Mass
124,184
Sequence
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=PLD1A; IsoId=Q13393-1; Sequence=Displayed; Name=PLD1B; IsoId=Q13393-2; Sequence=VSP_005020; Name=PLD1C; IsoId=Q13393-3; Sequence=VSP_005018, VSP_005019; Name=PLD1D; IsoId=Q13393-4; Sequence=VSP_005021, VSP_005022
Alternative Sequence
514..597; PAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLI -> IPGPSVVYRQVWESCMGKPDSGMERTTAISSSKTGFNLINLLLISLTGTPRPGCPGMTLPLQSTGRRLVMWHVTSSSAGTSQKL (in isoform PLD1C); 585..623; SYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHAD -> N (in isoform PLD1B); 598..1074; Missing (in isoform PLD1C); 962..971; VVLGYLDDPS -> SKMTPGVEDP (in isoform PLD1D); 972..1074; Missing (in isoform PLD1D)
3D Structural Models
Turn
396..399; 471..473; 670..672; 903..905; 1049..1052
Helix
339..341; 358..370; 401..410; 431..441; 646..648; 688..707; 709..711; 750..753; 761..772; 797..810; 836..850; 857..865; 866..871; 916..919; 950..964; 972..974; 980..985; 987..1002; 1013..1021; 1025..1028; 1030..1037; 1070..1072
Beta Strand
347..357; 373..382; 388..392; 414..420; 445..450; 466..470; 474..479; 681..686; 738..748; 774..782; 790..792; 816..820; 873..884; 887..892; 898..902; 906..911; 920..932; 934..941; 944..949; 1042..1046
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
81..212; PX; 219..328; PH; 459..486; PLD phosphodiesterase 1; 891..918; PLD phosphodiesterase 2
Region
463..928; Catalytic
Protein Families
Phospholipase D family
Sequence Similarities
Belongs to the phospholipase D family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs (7)
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |