Protein detail
MSLN
Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
Entry name MSLN | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 5 | Transmembrane count | Protein classification Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Mesothelin (CAK1 antigen) (Pre-pro-megakaryocyte-potentiating factor) [Cleaved into: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form]
Protein Class (5)
Cancer-related genesDisease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (3)
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CAK1MPF
Gene Description
Mesothelin
Chromosome
16
Position
760734-768865
Supporting publications (n)
5
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway6
Protein Function (3)
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function
Biological Process (3)
Reactome (3)
Mediation Categories (3)
Adhesion and uptake mediationClinical-translation mediationMetabolism mediation
Relations & Evidence24
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | Yes | No | Yes |
| peripheral | peripheral | UniProt_location | No | No | Yes | No | Yes |
| peripheral | peripheral | OmniPath | No | No | Yes | No | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | Yes | No | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | OmniPath | No | No | Yes | No | Yes |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | Yes |
| secreted | secreted | UniProt_location | No | No | Yes | No | Yes |
| secreted | secreted | OmniPath | No | No | Yes | No | Yes |
Protein Complex Composition (1)
Sequence, Structure & Domains12
Sequences
Length
630
Mass
68,986
Sequence
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q13421-1; Sequence=Displayed; Name=2; IsoId=Q13421-3; Sequence=VSP_021059; Name=3; Synonyms=SMRP; IsoId=Q13421-2; Sequence=VSP_021059, VSP_021060; Name=4; IsoId=Q13421-4; Sequence=VSP_021058, VSP_021059
Alternative Sequence
44; Missing (in isoform 4); 409..416; Missing (in isoform 2, isoform 3 and isoform 4); 601..630; MQEALSGTPCLLGPGPVLTVLALLLASTLA -> VQGGRGGQARAGGRAGGVEVGALSHPSLCRGPLGDALPPRTWTCSHRPGTAPSLHPGLRAPLPC (in isoform 3)
3D Structural Models
Turn
339..341; 402..404; 492..494
Helix
313..317; 320..326; 329..334; 336..338; 346..359; 366..369; 373..378; 381..385; 392..401; 419..430; 435..444; 446..448; 449..451; 454..458; 462..467; 470..473; 478..491; 497..504; 505..507; 508..510; 513..521; 528..531; 536..539; 544..551; 552..561; 565..571; 576..579; 580..582
Beta Strand
308..310; 562..564
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Region
262..286; Required for megakaryocyte-potentiating factor activity
Protein Families
Mesothelin family
Sequence Similarities
Belongs to the mesothelin family.
Clinical Relevance5
Disease Involvement
Cancer-related genes
Related Diseases (18)
Breast cancerCervical cancerEndometrial cancerFallopian tube cancerLiver cancerLung cancerLymphatic vessel/lymph nodes disorderMesothelial tumourMesothelin positive tumourMetastatic malignant neoplasmMetastatic pleura neoplasmNon-small-cell lung cancerOvarian cancerPancreatic cancerPeritoneal cancerPleural mesotheliomaSolid tumour/cancerStomach cancer
Biomarker
Phase 1/2; Phase 1; Phase 2
Drugs (9)
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 37403840 | Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. | No abstract available |
| 37427430 | Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis. | No abstract available |
| 37884576 | Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer. | No abstract available |
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |
| 40596376 | Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients. | No abstract available |