Protein detail
SNTA1
Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)
Protein symbol SNTA1 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
LQT12SNT1TACIP1
Gene Description
Syntrophin alpha 1
Chromosome
20
Position
33407957-33443763
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- Predicted intracellular proteins
Cellular Component
- GO:0005622 intracellular anatomical structure
- GO:0005737 cytoplasm
- GO:0005856 cytoskeleton
- GO:0016010 dystrophin-associated glycoprotein complex
- GO:0016013 syntrophin complex
- GO:0016328 lateral plasma membrane
- GO:0031594 neuromuscular junction
- GO:0032991 protein-containing complex
- GO:0042383 sarcolemma
- GO:0045211 postsynaptic membrane
- GO:0070161 anchoring junction
Molecular Function
- GO:0003779 actin binding
- GO:0005198 structural molecule activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0017080 sodium channel regulator activity
- GO:0030165 PDZ domain binding
- GO:0044325 transmembrane transporter binding
- GO:0050998 nitric-oxide synthase binding
- GO:0051117 ATPase binding
Biological Process
KEGG
Reactome
Canonical Pathways
M219 Pid hedgehog gli pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SNTA1 | MAPK12 | P53778 | S | 193 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite | HPRD:10212242HPRD:19413330SIGNOR:10212242KEA:10212242ProtMapper:10212242KEA:17081983HPRD:18669648phosphoELM:10212242 |
| SNTA1 | MAPK12 | P53778 | S | 201 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSite | HPRD:10212242SIGNOR:10212242KEA:10212242ProtMapper:10212242HPRD:20068231phosphoELM:10212242 |
| SNTA1 | MAPK12 | P53778 | S | 189 | phosphorylation | PhosphoNetworks | |
| SNTA1 | MAPK3 | P27361 | S | 193 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK3 | P27361 | S | 201 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK1 | P28482 | S | 193 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK1 | P28482 | S | 201 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK6 | Q16659 | S | 193 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK6 | Q16659 | S | 201 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| SNTA1 | MAPK4 | P31152 | S | 193 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
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Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| MK12 | P53778 | SNTA1 | Q13424 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEALit-BM-17DOMINOPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSPIKE_LCHPRD-phos | HPRD:10212242SIGNOR:10212242Lit-BM-17:10212242KEA:10212242HPRD-phos:10212242ProtMapper:10212242KEA:17081983ProtMapper:20068231DOMINO:10212242HPRD-phos:18669648HPRD-phos:19413330HPRD-phos:20068231ProtMapper:18669648phosphoELM:10212242ProtMapper:19413330SPIKE_LC:10212242 |
| SNTA1 | Q13424 | NOS1 | P29475 | Yes | Yes | No | HPRDHINTSIGNOR | HPRD:10221915HINT:9412493HPRD:11747091SIGNOR:12456711HINT:33961781 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
505
Mass
53,895
Sequence
MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13424-1; Sequence=Displayed; Name=2; IsoId=Q13424-2; Sequence=VSP_056827
Alternative Sequence
254..328; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.; DOMAIN: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).; DOMAIN: The SU domain binds calmodulin in a calcium-dependent manner.
Domain (FT)
6..269; PH 1; 87..170; PDZ; 293..401; PH 2; 449..505; SU
Region
1..25; Disordered; 40..77; Disordered; 180..210; Disordered; 483..505; Calmodulin-binding
Protein Families
Syntrophin family
Sequence Similarities
Belongs to the syntrophin family.