Protein detail

SNTA1

Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)

Protein symbol SNTA1	UniProt ID Q13424	EVMP score 0.38
Frequency	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Ensembl

ENSG00000101400

Entrez Gene Symbol

SNTA1

Gene Synonym

LQT12SNT1TACIP1

Gene Description

Syntrophin alpha 1

Chromosome

Position

33407957-33443763

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Disease related genes
Human disease related genes:Cardiovascular diseases:Cardiac diseases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M219 Pid hedgehog gli pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

27 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SNTA1	MAPK10	P53779	S	201	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SNTA1	NLK	Q9UBE8	S	193	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SNTA1	NLK	Q9UBE8	S	201	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
SNTA1	CDK1	P06493	S	193	phosphorylation	KEA	KEA:17570479
SNTA1	GSK3B	P49841	S	193	phosphorylation	KEA	KEA:17570479
SNTA1	GSK3B	P49841	S	201	phosphorylation	KEA	KEA:17570479
SNTA1	MAPK14	Q16539	S	201	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK12	P53778	SNTA1	Q13424	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEALit-BM-17DOMINOPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSPIKE_LCHPRD-phos	HPRD:10212242 SIGNOR:10212242 Lit-BM-17:10212242 KEA:10212242 HPRD-phos:10212242 ProtMapper:10212242 KEA:17081983 ProtMapper:20068231 DOMINO:10212242 HPRD-phos:18669648 HPRD-phos:19413330 HPRD-phos:20068231 ProtMapper:18669648 phosphoELM:10212242 ProtMapper:19413330 SPIKE_LC:10212242
SNTA1	Q13424	NOS1	P29475	Yes	Yes	No	HPRDHINTSIGNOR	HPRD:10221915 HINT:9412493 HPRD:11747091 SIGNOR:12456711 HINT:33961781

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Kir4.1-alpha-1-syntrophin complexcortical astrocytes	KCNJ10 SNTA1	P78508 Q13424	1:1	Compleat	Compleat:HC434	15102837
	SNTA1 SPZ1	Q13424 Q9BXG8	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	32384937 23161513 15326289 39940641 32249794 33345401

Sequence, Structure & Domains

Sequences

Length

505

Mass

53,895

Sequence

MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13424-1; Sequence=Displayed; Name=2; IsoId=Q13424-2; Sequence=VSP_056827

Alternative Sequence

254..328; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Domain (CC)

The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-bisphosphate.; DOMAIN: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).; DOMAIN: The SU domain binds calmodulin in a calcium-dependent manner.

Domain (FT)

6..269; PH 1; 87..170; PDZ; 293..401; PH 2; 449..505; SU

Region

1..25; Disordered; 40..77; Disordered; 180..210; Disordered; 483..505; Calmodulin-binding

Protein Families

Syntrophin family

Sequence Similarities

Belongs to the syntrophin family.

Clinical Relevance

Disease Involvement

Disease variantLong QT syndrome

Antibody

CAB037059 HPA067154

Interaction Protein

ENSG00000152818ENSG00000198947

Interaction Count

Interaction Dataset

biogrid_opencellintact_biogrid