Protein detail
SNTB2
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)
Entry name SNTB2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificplasmacytoid DC
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0005622 intracellular anatomical structure
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005874 microtubule
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0016010 dystrophin-associated glycoprotein complex
- GO:0016020 membrane
- GO:0030658 transport vesicle membrane
- GO:0032991 protein-containing complex
- GO:0045202 synapse
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SNTB2 | EGF | P01133 | S | 231 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| SNTB2 | CDK5 | Q00535 | S | 95 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:17209474 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
540
Mass
57,950
Sequence
MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta2-syntrophin58; IsoId=Q13425-1; Sequence=Displayed; Name=2; Synonyms=Beta2-syntrophin28; IsoId=Q13425-2; Sequence=VSP_006358, VSP_006359
Alternative Sequence
266..267; LI -> QN (in isoform 2); 268..540; Missing (in isoform 2)
3D Structural Models
Helix
134..136; 150..154; 176..184
Beta Strand
113..119; 127..133; 138..145; 161..166; 188..196
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
81..92; Low complexity; 93..102; Pro residues; 103..112; Low complexity; 222..231; Low complexity
Domain (CC)
The PH 1 domain mediates the oligomerization in a calcium dependent manner.; DOMAIN: The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).; DOMAIN: The SU domain binds calmodulin in a calcium-dependent manner.
Domain (FT)
115..198; PDZ; 163..300; PH 1; 325..437; PH 2; 484..540; SU
Region
73..114; Disordered; 220..240; Disordered; 518..540; Calmodulin-binding
Protein Families
Syntrophin family
Sequence Similarities
Belongs to the syntrophin family.
Clinical Relevance
Interaction Protein
ENSG00000147044ENSG00000152818ENSG00000165029ENSG00000171873ENSG00000198947
Interaction Count
5
Interaction Dataset
intact_biogridintact_biogrid_opencell