Protein detail

S39A6

Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)

Entry name S39A6	UniProt ID Q13433	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 6	Protein classification Metabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)

Protein Class (3)

Metabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

326..346; Helical; Name=1; 356..376; Helical; Name=2; 424..444; Helical; Name=3; 658..678; Helical; Name=4; 687..707; Helical; Name=5; 725..745; Helical; Name=6

Transmembrane Count

Ensembl

ENSG00000141424

Entrez Gene Symbol

SLC39A6

Gene Synonym

LIV-1

Gene Description

Solute carrier family 39 member 6

Chromosome

Position

36108531-36129385

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificCone photoreceptor cellsSecretome LocationIntracellular and membraneSecretome FunctionEnzyme

Function & Pathway8

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (5)

Canonical Pathways (3)

M5880 Naba ecm affiliated
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence28

Ligand-Receptor Signaling (26)

26 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NCR3LG1 PIP4P2 RYK SLC39A5 SLC39A6	P34925 Q13433 Q68D85 Q6ZMH5 Q8N4L2	0:0:0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	3	32384937 29603567 36028467

Sequence, Structure & Domains10

Sequences

Length

755

Mass

85,047

Sequence

MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13433-1; Sequence=Displayed; Name=2; IsoId=Q13433-2; Sequence=VSP_014309, VSP_014310, VSP_014311

Alternative Sequence

1..275; Missing (in isoform 2); 707..708; PE -> SF (in isoform 2); 709..755; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

95..128; Basic and acidic residues; 129..144; Basic residues; 145..159; Basic and acidic residues; 167..179; Basic and acidic residues; 219..234; Low complexity

Coiled Coil

464..480

Region

95..186; Disordered; 202..246; Disordered

Protein Families

ZIP transporter (TC 2.A.5) family

Sequence Similarities

Belongs to the ZIP transporter (TC 2.A.5) family.

Clinical Relevance4

Related Diseases (3)

Breast cancer Lung cancer Non-small-cell lung cancer

Biomarker

Phase 1; Phase 2

Drugs (2)

LADIRATUZUMAB VEDOTIN NULL

Antibody

HPA042377

Supporting Publications1

PMID	Title	Abstract
36550367	Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays.	No abstract available