Protein detail
GAB1
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Entry name GAB1 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNB26
Gene Description
GRB2 associated binding protein 1
Chromosome
4
Position
143336876-143474565
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05211 Renal cell carcinoma
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome
- R-hsa-9028335 activated ntrk2 signals through pi3k
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5654687 downstream signaling of activated fgfr1
- R-hsa-5654696 downstream signaling of activated fgfr2
- R-hsa-5654708 downstream signaling of activated fgfr3
- R-hsa-5654716 downstream signaling of activated fgfr4
- R-hsa-9027276 erythropoietin activates phosphoinositide 3 kinase pi3k
- R-hsa-180292 gab1 signalosome
- R-hsa-74751 insulin receptor signalling cascade
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-112399 irs mediated signalling
- R-hsa-8851907 met activates pi3k akt signaling
- R-hsa-8865999 met activates ptpn11
- R-hsa-8875555 met activates rap1 and rac1
- R-hsa-8875878 met promotes cell motility
- R-hsa-8875656 met receptor recycling
- R-hsa-199418 negative regulation of the pi3k akt network
- R-hsa-9675108 nervous system development
- R-hsa-2219528 pi3k akt signaling in cancer
- R-hsa-1963642 pi3k events in erbb2 signaling
- R-hsa-5654689 pi 3k cascade fgfr1
- R-hsa-5654695 pi 3k cascade fgfr2
- R-hsa-5654710 pi 3k cascade fgfr3
- R-hsa-5654720 pi 3k cascade fgfr4
- R-hsa-8853659 ret signaling
- R-hsa-177929 signaling by egfr
- R-hsa-1643713 signaling by egfr in cancer
- R-hsa-1227986 signaling by erbb2
- R-hsa-9665348 signaling by erbb2 ecd mutants
- R-hsa-1227990 signaling by erbb2 in cancer
- R-hsa-9006335 signaling by erythropoietin
- R-hsa-190236 signaling by fgfr
- R-hsa-5654736 signaling by fgfr1
- R-hsa-5655302 signaling by fgfr1 in disease
- R-hsa-5654738 signaling by fgfr2
- R-hsa-5655253 signaling by fgfr2 in disease
- R-hsa-5654741 signaling by fgfr3
- R-hsa-5654743 signaling by fgfr4
- R-hsa-5655291 signaling by fgfr4 in disease
- R-hsa-1226099 signaling by fgfr in disease
- R-hsa-74752 signaling by insulin receptor
- R-hsa-6806834 signaling by met
- R-hsa-9006115 signaling by ntrk2 trkb
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-2404192 signaling by type 1 insulin like growth factor 1 receptor igf1r
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
82 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAB1 | EGFR | P00533 | Y | 657 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | KEA:10978177KEA:9890893HPRD:10734310HPRD:20068231KEA:10734310HPRD:17389395HPRD:17016520 |
| GAB1 | EGFR | P00533 | Y | 689 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | KEA:10978177KEA:9890893HPRD:10734310HPRD:16497976HPRD:18669648KEA:10734310HPRD:17389395 |
| GAB1 | EGFR | P00533 | Y | 317 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:15231819 |
| GAB1 | INSR | P06213 | Y | 627 | phosphorylation | SIGNORProtMapperHPRDRLIMS-P_ProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893HPRD:10734310phosphoELM:10978177HPRD:20068231ProtMapper:10978177SIGNOR:10978177KEA:10734310HPRD:17389395HPRD:17016520 |
| GAB1 | INSR | P06213 | Y | 589 | phosphorylation | SIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893phosphoELM:10978177ProtMapper:10978177SIGNOR:10978177KEA:10734310 |
| GAB1 | INSR | P06213 | Y | 242 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177phosphoELM:10978177HPRD:16497976ProtMapper:10978177SIGNOR:10978177HPRD:10978177 |
| GAB1 | INSR | P06213 | Y | 373 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893phosphoELM:10978177HPRD:16497976ProtMapper:10978177KEA:10753869SIGNOR:10978177HPRD:10978177KEA:10734310HPRD:17389395 |
| GAB1 | INSR | P06213 | Y | 472 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893phosphoELM:10978177ProtMapper:10978177SIGNOR:10978177KEA:10734310 |
| GAB1 | INSR | P06213 | Y | 447 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893phosphoELM:10978177ProtMapper:10978177SIGNOR:10978177KEA:10734310 |
| GAB1 | INSR | P06213 | Y | 285 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:10978177KEA:9890893ProtMapper:10978177SIGNOR:10978177KEA:10734310 |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
Regulatory Interaction Network
14 records.
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Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
694
Mass
76,616
Sequence
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13480-1; Sequence=Displayed; Name=2; IsoId=Q13480-2; Sequence=VSP_017137
Alternative Sequence
528; K -> KGQSPKILRLKPHGLERTDSQTIGDFATRRK (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
145..157; Polar residues; 194..203; Basic and acidic residues; 204..231; Polar residues; 362..386; Polar residues; 594..611; Polar residues; 672..684; Basic and acidic residues; 685..694; Polar residues
Domain (FT)
5..116; PH
Region
122..164; Disordered; 194..231; Disordered; 323..386; Disordered; 493..532; Disordered; 544..656; Disordered; 671..694; Disordered
Protein Families
GAB family
Sequence Similarities
Belongs to the GAB family.