Protein detail
GAB1
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Entry name GAB1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Protein Class (4)
Disease related genesHuman disease related genesPredicted intracellular proteinsRAS pathway related proteins
Protein Function (4)
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNB26
Gene Description
GRB2 associated binding protein 1
Chromosome
4
Position
143336876-143474565
Supporting publications (n)
4
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway7
Protein Function (4)
- Disease related genes
- Predicted intracellular proteins
- RAS pathway related proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
KEGG (10)
- hsa01521 EGFR tyrosine kinase inhibitor resistance
- KEGG:hsa04012 ErbB signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05211 Renal cell carcinoma
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
Reactome (49)
- R-hsa-9028335 activated ntrk2 signals through pi3k
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5637810 constitutive signaling by egfrviii
- R-hsa-1236382 constitutive signaling by ligand responsive egfr cancer variants
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5654687 downstream signaling of activated fgfr1
- R-hsa-5654696 downstream signaling of activated fgfr2
- R-hsa-5654708 downstream signaling of activated fgfr3
- R-hsa-5654716 downstream signaling of activated fgfr4
- R-hsa-9027276 erythropoietin activates phosphoinositide 3 kinase pi3k
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Mediation Categories (3)
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence104
Enzyme-Mediated Modification (82)
82 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GAB1 | MET | P08581 | Y | 406 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMLi2012 | KEA:9890893HPRD:10734310ProtMapper:15212693phosphoELM:10734310KEA:10734310HPRD:16497976KEA:10753869HPRD:19901323HPRD:17389395HPRD:17016520 |
| GAB1 | MET | P08581 | Y | 472 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMLi2012 | KEA:10978177KEA:9890893HPRD:10734310ProtMapper:15212693phosphoELM:10734310KEA:10734310 |
| GAB1 | MET | P08581 | Y | 447 | phosphorylation | BEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMLi2012 | KEA:10978177KEA:9890893HPRD:10734310ProtMapper:15212693phosphoELM:10734310KEA:10734310 |
| GAB1 | MET | P08581 | Y | 619 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | KEA:10978177KEA:10734310KEA:9890893HPRD:10734310 |
| GAB1 | MET | P08581 | Y | 657 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | KEA:10978177KEA:9890893HPRD:10734310HPRD:20068231KEA:10734310HPRD:17389395HPRD:17016520 |
| GAB1 | MET | P08581 | Y | 689 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA | KEA:10978177KEA:9890893HPRD:10734310HPRD:16497976HPRD:18669648KEA:10734310HPRD:17389395 |
| GAB1 | MAPK1 | P28482 | T | 476 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15379552SIGNOR:15379552phosphoELM:15379552ProtMapper:15379552 |
| GAB1 | MAPK1 | P28482 | S | 381 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:15379552SIGNOR:15379552ProtMapper:15379552 |
| GAB1 | MAPK1 | P28482 | T | 312 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | KEA:15379552SIGNOR:15379552ProtMapper:15379552 |
| GAB1 | MAPK1 | P28482 | S | 551 | phosphorylation | SIGNOR_ProtMapperKEASIGNORProtMapper | KEA:15379552SIGNOR:15379552ProtMapper:15379552 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes | No | No | No | No |
| intracellular_intercellular_related | intracellular_intercellular_related | OmniPath | Yes | No | No | No | No |
Regulatory Interaction Network (14)
14 records.
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Protein Complex Composition (2)
Sequence, Structure & Domains11
Sequences
Length
694
Mass
76,616
Sequence
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13480-1; Sequence=Displayed; Name=2; IsoId=Q13480-2; Sequence=VSP_017137
Alternative Sequence
528; K -> KGQSPKILRLKPHGLERTDSQTIGDFATRRK (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
145..157; Polar residues; 194..203; Basic and acidic residues; 204..231; Polar residues; 362..386; Polar residues; 594..611; Polar residues; 672..684; Basic and acidic residues; 685..694; Polar residues
Domain (FT)
5..116; PH
Region
122..164; Disordered; 194..231; Disordered; 323..386; Disordered; 493..532; Disordered; 544..656; Disordered; 671..694; Disordered
Protein Families
GAB family
Sequence Similarities
Belongs to the GAB family.
Clinical Relevance6
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Drugs
Interaction Protein (7)
ENSG00000099942ENSG00000100351ENSG00000145675ENSG00000146648ENSG00000164924ENSG00000177885ENSG00000179295
Interaction Count
7
Interaction Dataset (2)
intact_biogridbiogrid_opencell
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No abstract available |