Protein detail
GPM6B
Neuronal membrane glycoprotein M6-b (M6b)
Entry name GPM6B | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuronal membrane glycoprotein M6-b (M6b)
Protein Class
Predicted membrane proteins
Transmembrane
31..51; Helical; 90..110; Helical; 136..156; Helical; 224..244; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
M6BMGC17150MGC54284
Gene Description
Glycoprotein M6B
Chromosome
X
Position
13770939-13938638
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M48 Pid met pathway
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
Mediation Categories (2)
Adhesion and uptake mediationFusion and delivery mediation
Relations & Evidence16
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | Yes | ||||
| transmembrane | transmembrane | UniProt_topology | Yes | ||||
| transmembrane | transmembrane | UniProt_keyword | Yes | ||||
| transmembrane | transmembrane | LOCATE | Yes | ||||
| transmembrane | transmembrane | Ramilowski_location | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes |
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Sequence, Structure & Domains
Sequences
Length
265
Mass
28,989
Sequence
MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=Q13491-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q13491-2; Sequence=VSP_003326; Name=3; IsoId=Q13491-3; Sequence=VSP_041121; Name=4; IsoId=Q13491-4; Sequence=VSP_041121, VSP_043247
Alternative Sequence
1..20; MKPAMETAAEENTEQSQERK -> M (in isoform 2); 20; K -> KVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSP (in isoform 3 and isoform 4); 240..265; LIYMMATTYNYAVLKFKSREDCCTKF -> IHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT (in isoform 4)
Domain & Motif Annotations
Protein Families
Myelin proteolipid protein family
Sequence Similarities
Belongs to the myelin proteolipid protein family.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |