Protein detail

GPM6B

Neuronal membrane glycoprotein M6-b (M6b)

Entry name GPM6B	UniProt ID Q13491	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 4	Protein classification Predicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Neuronal membrane glycoprotein M6-b (M6b)

Protein Class

Predicted membrane proteins

Transmembrane

31..51; Helical; 90..110; Helical; 136..156; Helical; 224..244; Helical

Transmembrane Count

Ensembl

ENSG00000046653

Entrez Gene Symbol

GPM6B

Gene Synonym (3)

M6BMGC17150MGC54284

Gene Description

Glycoprotein M6B

Chromosome

Position

13770939-13938638

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization4

Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells

Function & Pathway5

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Canonical Pathways (3)

M48 Pid met pathway
M5880 Naba ecm affiliated
M5885 Naba matrisome associated

Mediation Categories (2)

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence16

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	32384937 29635386

Sequence, Structure & Domains7

Sequences

Length

265

Mass

28,989

Sequence

MKPAMETAAEENTEQSQERKGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNASDHALLSEVIQLMQYVIYGIASFFFLYGIILLAEGFYTTSAVKELHGEFKTTACGRCISGMFVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVEQICVDIRQYGIIPWNAFPGKICGSALENICNTNEFYMSYHLFIVACAGAGATVIALLIYMMATTYNYAVLKFKSREDCCTKF

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=A; IsoId=Q13491-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q13491-2; Sequence=VSP_003326; Name=3; IsoId=Q13491-3; Sequence=VSP_041121; Name=4; IsoId=Q13491-4; Sequence=VSP_041121, VSP_043247

Alternative Sequence

1..20; MKPAMETAAEENTEQSQERK -> M (in isoform 2); 20; K -> KVNSRAEMEIGRYHWMYPGSKNHQYHPVPTLGDRASPLSSP (in isoform 3 and isoform 4); 240..265; LIYMMATTYNYAVLKFKSREDCCTKF -> IHFLMILSSNWAYLKDASKMQAYQDIKAKEEQELQDIQSRSKEQLNSYT (in isoform 4)

Domain & Motif Annotations

Protein Families

Myelin proteolipid protein family

Sequence Similarities

Belongs to the myelin proteolipid protein family.

Clinical Relevance2

Drugs (16)

AZD4625 ADAGRASIB MRTX1133 OPNURASIB LONAFARNIB ERAS-5024 SOTORASIB BI-0474 FULZERASIB ASP2453 COMPOUND 25 [PMID: 32023060]BI-2493 DIVARASIB LY3499446 -ARS 1620.00 LUNA18

Antibody

HPA002913

Supporting Publications1

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available