Protein detail
NAB1
NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54)
Entry name NAB1 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
NGFI-A-binding protein 1 (EGR-1-binding protein 1) (Transcriptional regulatory protein p54)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
NGFI-A binding protein 1
Chromosome
2
Position
190646746-190692766
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9619665 egr2 and sox10 mediated initiation of schwann cell myelination
- R-hsa-9675108 nervous system development
- R-hsa-9031628 ngf stimulated transcription
- R-hsa-198725 nuclear events kinase and transcription factor activation
- R-hsa-166520 signaling by ntrks
- R-hsa-9006934 signaling by receptor tyrosine kinases
Mediation Categories
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
487
Mass
54,401
Sequence
MAAALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEGSPTWLGISCSSYERSSNAREPHLKIPKCAATTCVQSLGQGKSDVVGSLALQSVGESRLWQGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLNEVKELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTKSKCGERDELSPKRIKVEDGFPDFQDSVQTLFQQARAKSEELAALSSQQPEKVMAKQMEFLCNQAGYERLQHAERRLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQPHHFVVDGELSRLYPSEAKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q13506-1; Sequence=Displayed; Name=Short; IsoId=Q13506-2; Sequence=VSP_003384
Alternative Sequence
336..364; Missing (in isoform Short)
3D Structural Models
Helix
193..209; 215..224; 227..232; 234..237; 243..252; 272..286; 288..291; 294..310
Beta Strand
255..257
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
409..418; Polar residues
Domain (CC)
The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.; DOMAIN: The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.
Region
4..82; NCD1; 162..188; Disordered; 221..310; NCD2; 307..338; Necessary for nuclear localization; 399..434; Disordered
Protein Families
NAB family
Sequence Similarities
Belongs to the NAB family.
Clinical Relevance
Antibody