Protein detail
KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Entry name KCC2B | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
CAM2CAMK2CAMKBCaMKIIbeta
Gene Description
Calcium/calmodulin dependent protein kinase II beta
Chromosome
7
Position
44210019-44334577
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificHofbauer cellsSingle-Nuclei Brain Specificfibroblast
Function & Pathway7
Protein Function (7)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:CAMK Ser/Thr protein kinases
- Disease related genes
Cellular Component (10)
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005813 centrosome
- GO:0005829 cytosol
- GO:0005954 calcium- and calmodulin-dependent protein kinase complex
- GO:0014069 postsynaptic density
- GO:0030666 endocytic vesicle membrane
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0043005 neuron projection
- GO:0045202 synapse
Molecular Function (8)
Biological Process (3)
KEGG (34)
- hsa04012 ErbB signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04360 Axon guidance
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Reactome (47)
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9609736 assembly and cell surface presentation of nmda receptors
- R-hsa-111932 camk iv mediated phosphorylation of creb
- R-hsa-5576891 cardiac conduction
- R-hsa-111996 ca dependent events
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-442742 creb1 phosphorylation through nmda receptor mediated activation of ras signaling
- R-hsa-442729 creb1 phosphorylation through the activation of camkii camkk camkiv cascasde
- R-hsa-1280215 cytokine signaling in immune system
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Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence32
Ligand-Receptor Signaling (14)
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network (16)
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2B | Q13554 | CTNB1 | P35222 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:24117889SIGNOR:24117889 |
| KCC2B | Q13554 | CYLD | Q9NQC7 | Yes | Yes | No | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:24614225SIGNOR:24614225 |
| KCC2B | Q13554 | GSK3A | P49840 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:20841359SIGNOR:20841359 |
| KCC2B | Q13554 | PLCB3 | Q01970 | Yes | No | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:15302935KEA:11325525ProtMapper:15302935ProtMapper:19651622KEA:16126727ProtMapper:20068231ProtMapper:11325525HPRD-phos:20068231HPRD-phos:18669648SIGNOR:11325525ProtMapper:18669648HPRD-phos:19651622HPRD:11325525HPRD-phos:15302935 |
| KCC2B | Q13554 | ETS1 | P14921 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | HPRD:12475968ProtMapper:12475968SIGNOR:12475968KEA:12475968 |
| KCC2B | Q13554 | GABR1 | Q9UBS5 | Yes | No | Yes | SIGNOR | SIGNOR:37686242 |
| KCC2B | Q13554 | RETR1 | Q9H6L5 | Yes | Yes | No | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:31930741PhosphoSite:31930741 |
| KCC2B | Q13554 | SCN5A | Q14524 | Yes | Yes | No | SIGNOR | SIGNOR:33410863 |
| KCC2B | Q13554 | AAPK1 | Q13131 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:15980064ProtMapper:15980064 |
| KCC2B | Q13554 | NMDE2 | Q13224 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD-phos:8940188KEA:8940188HPRD:8940188KEA:11306676ProtMapper:11306676HPRD:16436603HPRD:11306676ProtMapper:12147342HPRD-phos:11306676SIGNOR:8940188HPRD-phos:12147342KEA:12147342ProtMapper:8940188HPRD:12147342 |
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Protein Complex Composition (1)
Sequence, Structure & Domains15
Sequences
Length
666
Mass
72,678
Sequence
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
Alternative Products
Event=Alternative splicing; Named isoforms=8; Comment=The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms.; Name=4; IsoId=Q13554-1; Sequence=Displayed; Name=1; Synonyms=Beta; IsoId=Q13554-2; Sequence=VSP_004776; Name=2; Synonyms=Beta1, Beta'E; IsoId=Q13554-3; Sequence=VSP_004770, VSP_004771, VSP_004775, VSP_004776; Name=3; Synonyms=Beta2; IsoId=Q13554-4; Sequence=VSP_004770, VSP_004771, VSP_004774, VSP_004776; Name=5; Synonyms=Beta4, BetaE; IsoId=Q13554-5; Sequence=VSP_004770, VSP_004771, VSP_004776; Name=6; Synonyms=Beta6; IsoId=Q13554-6; Sequence=VSP_004773, VSP_004776, VSP_004777; Name=7; Synonyms=Beta7; IsoId=Q13554-7; Sequence=VSP_004770, VSP_004772; Name=8; IsoId=Q13554-8; Sequence=VSP_041219, VSP_004776
Alternative Sequence
316..340; Missing (in isoform 8); 316; V -> A (in isoform 2, isoform 3, isoform 5 and isoform 7); 317..533; Missing (in isoform 7); 317..340; Missing (in isoform 2, isoform 3 and isoform 5); 354..392; Missing (in isoform 3); 354..377; Missing (in isoform 6); 379..393; Missing (in isoform 2); 410..533; Missing (in isoform 1, isoform 2, isoform 3, isoform 5, isoform 6 and isoform 8); 559..584; Missing (in isoform 6)
3D Structural Models
Turn
34..36; 235..238; 257..259
Helix
52..67; 98..102; 110..129; 139..141; 178..180; 183..186; 194..209; 219..228; 243..252; 263..266; 270..273; 275..278; 285..298; 534..551; 554..560; 570..572; 581..588; 592..594
Beta Strand
14..19; 27..33; 39..46; 76..81; 83..91; 95..97; 142..145; 153..155; 239..241; 561..568; 577..580; 598..609; 611..626; 632..646; 649..659
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
354..369; Polar residues; 432..447; Pro residues; 479..491; Low complexity; 514..531; Pro residues
Domain (CC)
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Domain (FT)
14..272; Protein kinase
Region
283..292; Autoinhibitory domain; 291..301; Calmodulin-binding; 349..534; Disordered
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance6
Disease Involvement
Intellectual disability
Drugs (20)
Interaction Protein (4)
ENSG00000070808ENSG00000102893ENSG00000145349ENSG00000254470
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |
| 39408670 | Proteomic Characterization of Corneal Epithelial and Stromal Cell-Derived Extracellular Vesicles. | No abstract available |
| 40689422 | Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles. | No abstract available |