Protein detail

KCC2G

Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)

Entry name
KCC2G
UniProt ID
Q13555
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)
Protein Class (8)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (8)
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:CAMK Ser/Thr protein kinases
  • Disease related genes
Ensembl
ENSG00000148660
Entrez Gene Symbol
CAMK2G
Gene Synonym
CAMKG
Gene Description
Calcium/calmodulin dependent protein kinase II gamma
Chromosome
10
Position
73812501-73874591
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificmonocytesBlood Cell Specificneutrophil
Function & Pathway
Protein Function (8)
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Transporters:Accessory Factors Involved in Transport
  • Kinases:CAMK Ser/Thr protein kinases
  • Disease related genes
Cellular Component (9)
Molecular Function (8)
Biological Process (3)
KEGG (34)
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Reactome (47)
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence47

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CAMK2GCAMK2BQ13554T287phosphorylationPhosphoSite
CAMK2GPRKACBP22694S333phosphorylationKEAKEA:17570479
CAMK2GPRKCAP17252S315phosphorylationKEAKEA:17570479
CAMK2GPRKCAP17252T287phosphorylationKEAKEA:17570479
CAMK2GRPS6KA3P51812T287phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (14)

14 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorscConnectYes
transmembranetransmembrane_predictedPhobius
transmembrane_phobiustransmembrane_predictedAlmen2009
transmembrane_sosuitransmembrane_predictedAlmen2009
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Regulatory Interaction Network (24)

24 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
KCC2GQ13555EGFRP00533YesYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperKEA:15302935KEA:92065884KEA:7505275ProtMapper:16799092KEA:3138233HPRD:1309762KEA:10347170KEA:16799092SIGNOR:1309762HPRD:10347170KEA:7805884ProtMapper:1309762KEA:1309762ProtMapper:10347170
KCC2GQ13555RADP55042YesPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperProtMapper:9677319ProtMapper:7876254HINT:9115241KEA:7876254KEA:9677319SIGNOR:9677319HINT:9677319HPRD:9677319HPRD:7876254
KCC2GQ13555SYN1P17600YesYesWangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperSIGNOR:3118371KEA:3118371ProtMapper:3118371KEA:12237306ProtMapper:30028969KEA:15822905HPRD:3118371
KCC2GQ13555SCN8AQ9UQD0YesYesSIGNORSIGNOR:32611770
KCC2GQ13555CLATP28329YesYesPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosHPRD:12486117HPRD-phos:12486117SIGNOR:12486117KEA:12486117ProtMapper:12486117
KCC2GQ13555PEA15Q15121YesSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosHPRD-phos:18669648SIGNOR:9721757HPRD-phos:18767875ProtMapper:19413330HPRD-phos:18578522HPRD-phos:20068231ProtMapper:20032303KEA:9721757ProtMapper:18212344ProtMapper:27317964HPRD-phos:18452278ProtMapper:18767875HPRD-phos:9721757ProtMapper:19651622HPRD-phos:18212344HPRD-phos:12808093ProtMapper:17287340KEA:12808093ProtMapper:18578522HPRD:9721757HPRD-phos:17287340HPRD:12808093ProtMapper:20068231ProtMapper:12808093ProtMapper:20166139ProtMapper:24657708HPRD-phos:19413330ProtMapper:18669648ProtMapper:18452278ProtMapper:9721757HPRD-phos:19651622ProtMapper:19664995HPRD-phos:19664995HPRD-phos:20166139
KCC2GQ13555ADCY3O60266YesYesphosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosHPRD-phos:9768837ProtMapper:9768837KEA:8798667SIGNOR:8798667ProtMapper:8798667HPRD-phos:8798667KEA:9768837HPRD:8798667HPRD:9768837
KCC2GQ13555NCOR2Q9Y618YesYesSIGNOR_ProtMapperiPTMnetSIGNORProtMapperProtMapper:22888005SIGNOR:22888005
KCC2GQ13555FLNAP21333YesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosKEA:11290523ProtMapper:11290523HPRD-phos:11290523HPRD:11290523SIGNOR:11290523
KCC2GQ13555GRIA1P42261YesYesSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperHPRD-phosProtMapper:19046328HPRD-phos:9407043ProtMapper:11640921ProtMapper:27019755ProtMapper:12609872ProtMapper:18045915ProtMapper:21856433KEA:12609872KEA:8663994HPRD-phos:12609872ProtMapper:24712994ProtMapper:29476449ProtMapper:25381005SIGNOR:7877986iPTMnet:9407043SIGNOR:12609872ProtMapper:19376069HPRD:9407043KEA:7877986HPRD:7877986ProtMapper:20646058ProtMapper:9407043ProtMapper:26668821HPRD:12609872KEA:9407043ProtMapper:7877986
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Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
AHCYCAMK2GMYLKPRKG2P23526Q13237Q13555Q157461:1:1:1NetworkBlastCompleatCompleat:HC8539
CAMK2GQ135556PDBPDB:2ux0
CAMK2GPFDN5Q13555Q994710:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass Spectrometry138037300
Sequence, Structure & Domains

Sequences

Length
558
Mass
62,607
Sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
Alternative Products
Event=Alternative splicing; Named isoforms=11; Name=1; IsoId=Q13555-1; Sequence=Displayed; Name=2; IsoId=Q13555-2; Sequence=VSP_013349; Name=3; IsoId=Q13555-3; Sequence=VSP_013350; Name=4; IsoId=Q13555-4; Sequence=VSP_004778; Name=5; IsoId=Q13555-5; Sequence=VSP_032699, VSP_032700, VSP_004778; Name=6; IsoId=Q13555-6; Sequence=VSP_032699, VSP_035456; Name=7; Synonyms=gamma F; IsoId=Q13555-7; Sequence=VSP_013350, VSP_035456; Name=8; Synonyms=gamma E; IsoId=Q13555-8; Sequence=VSP_013349, VSP_035456; Name=9; Synonyms=gamma D; IsoId=Q13555-9; Sequence=VSP_013349, VSP_036027, VSP_035456; Name=10; IsoId=Q13555-10; Sequence=VSP_013350, VSP_004778; Name=11; IsoId=Q13555-11; Sequence=VSP_059393, VSP_013349, VSP_059394
Alternative Sequence
315; S -> SVGRQSSAPASPAASAAGLAGQ (in isoform 5 and isoform 6); 316; A -> VGRQSSAPASPAASAAGLAGQA (in isoform 11); 331..364; Missing (in isoform 3, isoform 7 and isoform 10); 331..341; Missing (in isoform 2, isoform 8, isoform 9 and isoform 11); 341..363; Missing (in isoform 5); 351..364; Missing (in isoform 9); 396..426; GRVPEGRSSRDRTAPSAGMQPQPSLCSSAMR -> VR (in isoform 11); 396..425; GRVPEGRSSRDRTAPSAGMQPQPSLCSSAM -> V (in isoform 4, isoform 5 and isoform 10); 397..398; RV -> APLRTGNGSSV (in isoform 6, isoform 7, isoform 8 and isoform 9)

3D Structural Models

Turn
34..37; 257..259; 482..485
Helix
9..13; 52..67; 98..103; 110..129; 139..141; 178..180; 183..187; 194..209; 219..227; 237..240; 243..252; 263..266; 270..273; 275..278; 285..301; 425..443; 446..452; 462..464; 471..481
Beta Strand
14..22; 26..33; 38..46; 76..81; 83..91; 142..145; 153..155; 453..460; 468..470; 490..501; 506..518; 524..538; 541..550
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
342..352; Polar residues; 394..408; Basic and acidic residues
Domain (CC)
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Domain (FT)
14..272; Protein kinase
Region
283..292; Autoinhibitory domain; 294..316; Calmodulin-binding; 324..353; Disordered; 376..423; Disordered
Protein Families (3)
  • Protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance
Disease Involvement
Intellectual disability
Related Diseases
Intellectual disability
Drugs (21)
MEDICATIONLY-2090314AZD-1080GW441756XCENISERTIBBOSUTINIBHALOPERIDOL DECANOATENVP-TAE684SP-600125LITHIUMSOTRASTAURINDOVITINIBILORASERTIBTAMATINIBSNS-314ANTIDEPRESSANT AGENTPF-562271LINIFANIBBAY 61-3606GEFITINIBCYC-116
Antibody (3)
HPA051783HPA051785HPA053973
Interaction Protein
ENSG00000145349
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications1
PMIDTitleRelated sentences
40689422Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.No related sentences available