Protein detail
KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Protein symbol KCC2D | UniProt ID | EVMP score 0.88 |
Frequency 41 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Protein Class
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym
CAMKD
Gene Description
Calcium/calmodulin dependent protein kinase II delta
Chromosome
4
Position
113418054-113761927
Frequency
41
EVMP Score
0.88
Fluorescence & Localization
Tissue Specificbone marrowBrain Regional Specificcerebral cortexCell SpecificNeutrophilsBlood Cell Specificclassical monocyteBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Cellular Component
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005954 calcium- and calmodulin-dependent protein kinase complex
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030666 endocytic vesicle membrane
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0042383 sarcolemma
- GO:0043005 neuron projection
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004683 calcium/calmodulin-dependent protein kinase activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0019871 sodium channel inhibitor activity
- GO:0031432 titin binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0044325 transmembrane transporter binding
- GO:0106310 protein serine kinase activity
Biological Process
KEGG
- hsa04012 ErbB signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04722 Neurotrophin signaling pathway
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04740 Olfactory transduction
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04922 Glucagon signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04971 Gastric acid secretion
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05214 Glioma
- KEGG:hsa05415 Diabetic cardiomyopathy
- KEGG:hsa05417 Lipid and atherosclerosis
Reactome
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9609736 assembly and cell surface presentation of nmda receptors
- R-hsa-111932 camk iv mediated phosphorylation of creb
- R-hsa-5576891 cardiac conduction
- R-hsa-111996 ca dependent events
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-442742 creb1 phosphorylation through nmda receptor mediated activation of ras signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-418594 g alpha i signalling events
- R-hsa-112040 g protein mediated events
- R-hsa-3371571 hsf1 dependent transactivation
- R-hsa-5663205 infectious disease
- R-hsa-877300 interferon gamma signaling
- R-hsa-913531 interferon signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-9620244 long term potentiation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-397014 muscle contraction
- R-hsa-9617324 negative regulation of nmda receptor mediated neuronal transmission
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-111885 opioid signalling
- R-hsa-5576892 phase 0 rapid depolarisation
- R-hsa-5673000 raf activation
- R-hsa-442982 ras activation upon ca2 influx through nmda receptor
- R-hsa-9022692 regulation of mecp2 expression and activity
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-372790 signaling by gpcr
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-399719 trafficking of ampa receptors
- R-hsa-8986944 transcriptional regulation by mecp2
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
- R-hsa-438066 unblocking of nmda receptors glutamate binding and activation
- R-hsa-9824446 viral infection pathways
Canonical Pathways
M108 Pid netrin pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CAMK2D | PRKCB | P05771 | T | 287 | phosphorylation | KEA | KEA:17570479 |
| CAMK2D | RPS6KB1 | P23443 | T | 287 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
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Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2D | Q13557 | VIME | P08670 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:10852918HPRD-phos:18669648HPRD:15345747HPRD-phos:10852918ProtMapper:15345747KEA:9794428KEA:12761892KEA:16140754HPRD-phos:20068231HPRD-phos:15345747HPRD:10852918KEA:15345747SIGNOR:16140754ProtMapper:10852918ProtMapper:20166139ProtMapper:20068231ProtMapper:16140754ProtMapper:18669648HPRD-phos:20166139 |
| KCC2D | Q13557 | CEAM1 | P13688 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite | SIGNOR:24302721PhosphoSite:17546042PhosphoSite:19909740ProtMapper:24302721PhosphoSite:24302721 |
| KCC2D | Q13557 | SCN5A | Q14524 | Yes | Yes | Yes | PhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperIntActSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:33410863IntAct:22514276SIGNOR:28882890SIGNOR:22514276ProtMapper:22514276 |
| KCC2D | Q13557 | TPD52 | P55327 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:20946871PhosphoSite:18832449SIGNOR:20032513SIGNOR:20946871ProtMapper:20946871PhosphoSite:20032513PhosphoSite:23868405ProtMapper:20032513 |
| KCC2D | Q13557 | SCN8A | Q9UQD0 | Yes | Yes | No | SIGNOR | SIGNOR:32611770 |
| KCC2D | Q13557 | KCJ11 | Q14654 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:23223335ProtMapper:23223335PhosphoSite:24101510 |
| KCC2D | Q13557 | ANR28 | O15084 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:17023142SIGNOR:17023142PhosphoSite:17023142 |
| KCC2D | Q13557 | HDAC4 | P56524 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperHINTSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HINT:16767219HINT:17179159ProtMapper:17179159SIGNOR:17179159PhosphoSite:17179159 |
| KCC2D | Q13557 | ITPR2 | Q14571 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:23019322SIGNOR:23019322 |
| KCC2D | Q13557 | CACB2 | Q08289 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSite | ProtMapper:20194790SIGNOR:20194790PhosphoSite:20194790 |
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Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CALM3CAMK2DIKBKGMYC | P01106P0DP25Q13557Q9Y6K9 | 1:1:1:1 | CompleatCFinder | Compleat:HC8299 | ||
| CALM1CAMK2D | P0DP23Q13557 | 2:2 | PDB | PDB:7zrqPDB:2welPDB:7zrp | ||
| CAMK2DMMUT | P22033Q13557 | 0:0 | hu.MAP | |||
| CAMK2D | Q13557 | 2 | PDB | PDB:2w2cPDB:6aywPDB:9blhPDB:5vloPDB:2vn9 |
Sequence, Structure & Domains
Sequences
Length
499
Mass
56,369
Sequence
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
Alternative Products
Event=Alternative splicing; Named isoforms=10; Name=Delta 2; IsoId=Q13557-1; Sequence=Displayed; Name=Delta 3; IsoId=Q13557-3; Sequence=VSP_023096; Name=Delta 4; IsoId=Q13557-4; Sequence=VSP_023097; Name=Delta 6; IsoId=Q13557-8; Sequence=VSP_023099; Name=Delta 7; IsoId=Q13557-9; Sequence=VSP_023096, VSP_023099; Name=Delta 8; IsoId=Q13557-5; Sequence=VSP_023097, VSP_023099; Name=Delta 9; IsoId=Q13557-6; Sequence=VSP_023098; Name=Delta 10; IsoId=Q13557-10; Sequence=VSP_023098, VSP_023099; Name=Delta 11; IsoId=Q13557-11; Sequence=VSP_023095; Name=Delta 12; IsoId=Q13557-12; Sequence=VSP_041820, VSP_023099
Alternative Sequence
328; K -> KKRKSSSSVQMMEPQTTVIHNPDGNK (in isoform Delta 11); 328; K -> KKRKSSSSVQMM (in isoform Delta 3 and isoform Delta 7); 328; K -> KINNKANVVTSPKENIPTPAL (in isoform Delta 4 and isoform Delta 8); 329; E -> EPQTTVIHNPDGNKE (in isoform Delta 9 and isoform Delta 10); 478; K -> N (in isoform Delta 12); 479..499; Missing (in isoform Delta 6, isoform Delta 7, isoform Delta 8, isoform Delta 10 and isoform Delta 12)
3D Structural Models
Turn
34..36; 235..240; 257..259; 311..313
Helix
10..13; 47..49; 52..67; 98..105; 110..129; 139..141; 158..160; 178..180; 183..186; 194..209; 219..228; 243..252; 263..266; 270..273; 275..278; 296..310; 340..363; 366..372; 382..384; 393..401
Beta Strand
14..23; 26..33; 39..46; 76..82; 85..90; 142..148; 153..155; 373..380; 389..392; 410..421; 426..438; 444..458; 461..470
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Domain (CC)
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Domain (FT)
14..272; Protein kinase
Region
283..292; Autoinhibitory domain; 291..301; Calmodulin-binding
Protein Families
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000058404ENSG00000070808ENSG00000100246ENSG00000129245ENSG00000148660
Interaction Count
5
Interaction Dataset
intact_biogrid