Protein detail
KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Entry name KCC2D | UniProt ID | EVMP confidence score 0.88 |
Supporting publications (n) 41 | Transmembrane count | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Protein Class (4)
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym
CAMKD
Gene Description
Calcium/calmodulin dependent protein kinase II delta
Chromosome
4
Position
113418054-113761927
Supporting publications (n)
41
EVMP confidence score
0.88
Fluorescence & Localization5
Tissue Specificbone marrowBrain Regional Specificcerebral cortexCell SpecificNeutrophilsBlood Cell Specificclassical monocyteBlood Lineage Specificgranulocytes
Function & Pathway8
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
- Kinases:CAMK Ser/Thr protein kinases
Cellular Component (11)
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005954 calcium- and calmodulin-dependent protein kinase complex
- GO:0014069 postsynaptic density
- GO:0016020 membrane
- GO:0030666 endocytic vesicle membrane
- GO:0033017 sarcoplasmic reticulum membrane
- GO:0042383 sarcolemma
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Molecular Function (11)
- GO:0004674 protein serine/threonine kinase activity
- GO:0004683 calcium/calmodulin-dependent protein kinase activity
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0019871 sodium channel inhibitor activity
- GO:0031432 titin binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0044325 transmembrane transporter binding
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Biological Process (3)
KEGG (34)
- hsa04012 ErbB signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04066 HIF-1 signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04360 Axon guidance
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Reactome (46)
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9609736 assembly and cell surface presentation of nmda receptors
- R-hsa-111932 camk iv mediated phosphorylation of creb
- R-hsa-5576891 cardiac conduction
- R-hsa-111996 ca dependent events
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-3371556 cellular response to heat stress
- R-hsa-442742 creb1 phosphorylation through nmda receptor mediated activation of ras signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1489509 dag and ip3 signaling
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Canonical Pathways
M108 Pid netrin pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence34
Enzyme-Mediated Modification (2)
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CAMK2D | PRKCB | P05771 | T | 287 | phosphorylation | KEA | KEA:17570479 |
| CAMK2D | RPS6KB1 | P23443 | T | 287 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (15)
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
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Regulatory Interaction Network (12)
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2D | Q13557 | KCNQ1 | P51787 | Yes | No | Yes | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:29410121SIGNOR:29410121 |
| KCC2D | Q13557 | TITIN | Q8WZ42 | Yes | No | No | iPTMnetPhosphoSite_norefProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:23220127 |
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Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CALM3CAMK2DIKBKGMYC | P01106P0DP25Q13557Q9Y6K9 | 1:1:1:1 | CompleatCFinder | Compleat:HC8299 | ||
| CALM1CAMK2D | P0DP23Q13557 | 2:2 | PDB | PDB:7zrqPDB:2welPDB:7zrp | ||
| CAMK2DMMUT | P22033Q13557 | 0:0 | hu.MAP | |||
| CAMK2D | Q13557 | 2 | PDB | PDB:2w2cPDB:6aywPDB:9blhPDB:5vloPDB:2vn9 |
Sequence, Structure & Domains14
Sequences
Length
499
Mass
56,369
Sequence
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
Alternative Products
Event=Alternative splicing; Named isoforms=10; Name=Delta 2; IsoId=Q13557-1; Sequence=Displayed; Name=Delta 3; IsoId=Q13557-3; Sequence=VSP_023096; Name=Delta 4; IsoId=Q13557-4; Sequence=VSP_023097; Name=Delta 6; IsoId=Q13557-8; Sequence=VSP_023099; Name=Delta 7; IsoId=Q13557-9; Sequence=VSP_023096, VSP_023099; Name=Delta 8; IsoId=Q13557-5; Sequence=VSP_023097, VSP_023099; Name=Delta 9; IsoId=Q13557-6; Sequence=VSP_023098; Name=Delta 10; IsoId=Q13557-10; Sequence=VSP_023098, VSP_023099; Name=Delta 11; IsoId=Q13557-11; Sequence=VSP_023095; Name=Delta 12; IsoId=Q13557-12; Sequence=VSP_041820, VSP_023099
Alternative Sequence
328; K -> KKRKSSSSVQMMEPQTTVIHNPDGNK (in isoform Delta 11); 328; K -> KKRKSSSSVQMM (in isoform Delta 3 and isoform Delta 7); 328; K -> KINNKANVVTSPKENIPTPAL (in isoform Delta 4 and isoform Delta 8); 329; E -> EPQTTVIHNPDGNKE (in isoform Delta 9 and isoform Delta 10); 478; K -> N (in isoform Delta 12); 479..499; Missing (in isoform Delta 6, isoform Delta 7, isoform Delta 8, isoform Delta 10 and isoform Delta 12)
3D Structural Models
Turn
34..36; 235..240; 257..259; 311..313
Helix
10..13; 47..49; 52..67; 98..105; 110..129; 139..141; 158..160; 178..180; 183..186; 194..209; 219..228; 243..252; 263..266; 270..273; 275..278; 296..310; 340..363; 366..372; 382..384; 393..401
Beta Strand
14..23; 26..33; 39..46; 76..82; 85..90; 142..148; 153..155; 373..380; 389..392; 410..421; 426..438; 444..458; 461..470
3D Structure
X-ray crystallography (9)
Domain & Motif Annotations
Domain (CC)
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Domain (FT)
14..272; Protein kinase
Region
283..292; Autoinhibitory domain; 291..301; Calmodulin-binding
Protein Families (3)
- Protein kinase superfamily
- CAMK Ser/Thr protein kinase family
- CaMK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Clinical Relevance5
Drugs (15)
Interaction Protein (5)
ENSG00000058404ENSG00000070808ENSG00000100246ENSG00000129245ENSG00000148660
Interaction Count
5
Interaction Dataset
intact_biogrid
Supporting Publications41
| PMID | Title | Abstract |
|---|---|---|
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No abstract available |
| 36736734 | Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus. | No abstract available |
| 37204515 | Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 37670049 | Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility. | No abstract available |
| 37926756 | Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells. | No abstract available |
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 38607062 | Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes. | No abstract available |