Protein detail
PKD2
Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)
Entry name PKD2 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransportersVoltage-gated ion channels |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)
Protein Class (8)
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransportersVoltage-gated ion channels
Protein Function (6)
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Transporters:Transporter channels and pores
- Predicted secreted proteins
- Disease related genes
Transmembrane
220..241; Helical; Name=S1; 469..489; Helical; Name=S2; 506..526; Helical; Name=S3; 553..573; Helical; Name=S4; 598..619; Helical; Name=5; 655..675; Helical; Name=S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
Pc-2PC2PKD4TRPP2
Gene Description
Polycystin 2, transient receptor potential cation channel
Chromosome
4
Position
88007635-88077777
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization5
Tissue SpecificepididymisCell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway6
Protein Function (6)
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Transporters:Transporter channels and pores
- Predicted secreted proteins
- Disease related genes
Cellular Component (25)
- GO:0002133 polycystin complex
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005929 cilium
- GO:0009925 basal plasma membrane
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Molecular Function (23)
- GO:0005102 signaling receptor binding
- GO:0005244 voltage-gated monoatomic ion channel activity
- GO:0005245 voltage-gated calcium channel activity
- GO:0005248 voltage-gated sodium channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0005261 monoatomic cation channel activity
- GO:0005262 calcium channel activity
- GO:0005267 potassium channel activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
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Biological Process (3)
Reactome (4)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence60
Enzyme-Mediated Modification (7)
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKD2 | CSNK2A1 | P68400 | S | 812 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14742446ProtMapper:14742446phosphoELM:14742446SIGNOR:14742446 |
| PKD2 | PRKD1 | Q15139 | S | 801 | phosphorylation | RLIMS-P_ProtMapperSIGNORProtMapper | SIGNOR:20881056ProtMapper:20881056 |
| PKD2 | GSK3A | P49840 | S | 76 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16551655SIGNOR:16551655 |
| PKD2 | AURKA | O14965 | S | 829 | phosphorylation | RLIMS-P_ProtMapperPhosphoSiteProtMapper | ProtMapper:21670214 |
| PKD2 | PRKACA | P17612 | S | 829 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PKD2 | PRKD2 | Q9BZL6 | S | 801 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PKD2 | CCKBR | P32239 | S | 244 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:17962809 |
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| transporter | transporter | Surfaceome | No | Yes | Yes | No | No |
| trp_channels | transporter | Surfaceome | No | Yes | Yes | No | No |
| channels | transporter | Surfaceome | No | Yes | Yes | No | No |
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Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | PKD2 | Q13563 | Yes | Yes | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:14742446ProtMapper:14742446phosphoELM:14742446KEA:14742446PhosphoSite:23838289PhosphoSite:14742446 |
| KPCD1 | Q15139 | PKD2 | Q13563 | Yes | Yes | No | iPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapper | SIGNOR:20881056ProtMapper:20881056 |
| GSK3A | P49840 | PKD2 | Q13563 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16551655PhosphoSite:16551655SIGNOR:16551655 |
| KPCD2 | Q9BZL6 | PKD2 | Q13563 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20881056PhosphoSite:20881056 |
| AURKA | O14965 | PKD2 | Q13563 | Yes | No | No | iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21670214PhosphoSite:26269590PhosphoSite:23390129 |
Protein Complex Composition (9)
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARF1-ARL1-PKD2-ARFIP2 complex | ARF1ARFIP2ARL1PKD2 | P40616P53365P84077Q13563 | 0:0:0:0 | CORUM | CORUM:7483 | 26507660 |
| PKD2-FPC complex | PKD2PKHD1 | P08F94Q13563 | 1:1 | CompleatCORUM | Compleat:HC1555CORUM:1071 | 17008358 |
| Pkd2-Fpc-Kif3a complex | KIF3APKD2PKD2L1PKHD1 | P08F94Q13563Q9P0L9Q9Y496 | 1:1:1:1 | Compleat | Compleat:HC46 | 17283055 |
| Pkd2-Fpc-Kif3b complex | KIF3BKIF3CPKD2PKD2L1PKHD1 | O14782O15066P08F94Q13563Q9P0L9 | 1:1:1:1:1 | Compleat | Compleat:HC2654 | 17008358 |
| Pkhd1-Pkd2 complex | PKD2PKD2L1PKHD1 | P08F94Q13563Q9P0L9 | 1:1:1 | Compleat | Compleat:HC2199 | 17283055 |
| PKD2 | Q13563 | 4 | PDB | PDB:5k47PDB:5t4dPDB:6d1wPDB:9dliPDB:5mkfPDB:8k3sPDB:6t9nPDB:5mkePDB:8hk7PDB:6t9oPDB:6wb8PDB:9dwq | ||
| FAM3DPKD2 | Q13563Q96BQ1 | 0:0 | hu.MAP | |||
| FAM3DPKD2PKD2L2 | Q13563Q96BQ1Q9NZM6 | 0:0:0 | hu.MAP2 | |||
| PKD2L1 | Q9P0L9 | 6 | PDB | PDB:6du8PDB:3te3 |
Sequence, Structure & Domains16
Sequences
Length
968
Mass
109,691
Sequence
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q13563-1; Sequence=Displayed; Name=2; Synonyms=delta6; IsoId=Q13563-2; Sequence=VSP_042479, VSP_042480; Name=3; Synonyms=delta7; IsoId=Q13563-3; Sequence=VSP_042481; Name=4; Synonyms=delta9; IsoId=Q13563-4; Sequence=VSP_042482, VSP_042483; Name=5; Synonyms=delta12/13; IsoId=Q13563-5; Sequence=VSP_042484
Alternative Sequence
476..483; CEIIFCFF -> FICSSYGD (in isoform 2); 484..968; Missing (in isoform 2); 517..572; Missing (in isoform 3); 633..646; IFTQFRIILGDINF -> IICSWRSSMIRTLK (in isoform 4); 647..968; Missing (in isoform 4); 748..841; Missing (in isoform 5)
3D Structural Models
Turn
338..340; 350..352; 431..434; 499..501; 578..580; 620..622; 670..672; 730..734; 745..747; 781..783
Helix
215..240; 244..257; 270..272; 276..284; 286..291; 328..330; 335..337; 364..366; 371..374; 399..411; 468..497; 502..504; 506..529; 530..532; 533..540; 549..571; 572..576; 581..619; 624..626; 629..641; 646..652; 656..669; 673..691; 738..744; 752..762; 773..777; 836..894
Beta Strand
262..265; 304..306; 308..326; 382..386; 390..394; 419..430; 435..444; 447..450; 452..460; 542..544; 763..766; 767..771; 793..795
3D Structure
Electron microscopy (21); NMR spectroscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..11; Polar residues; 62..83; Low complexity; 95..107; Acidic residues; 123..139; Low complexity; 770..795; Basic and acidic residues; 796..807; Low complexity; 938..951; Low complexity
Motif
641..643; Selectivity filter
Coiled Coil
833..872
Domain (FT)
750..785; EF-hand
Region
1..28; Disordered; 58..181; Disordered; 764..831; Disordered; 803..822; Linker; 810..821; Important for interaction with PACS1 and PACS2; 917..968; Disordered
Protein Families
Polycystin family
Sequence Similarities
Belongs to the polycystin family.
Clinical Relevance6
Disease Involvement (2)
CiliopathyDisease variant
Drugs
Interaction Protein (2)
ENSG00000008710ENSG00000144935
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 29436780 | Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells. | No abstract available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 30950185 | Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer. | No abstract available |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |