Protein detail
PKD2
Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)
Protein symbol PKD2 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransportersVoltage-gated ion channels |
Basic Information
Protein Names
Polycystin-2 (PC2) (Autosomal dominant polycystic kidney disease type II protein) (Polycystic kidney disease 2 protein) (Polycystwin) (R48321) (Transient receptor potential cation channel subfamily P member 2)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted membrane proteinsPredicted secreted proteinsTransportersVoltage-gated ion channels
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Transporters:Transporter channels and pores
- Predicted secreted proteins
- Disease related genes
Transmembrane
220..241; Helical; Name=S1; 469..489; Helical; Name=S2; 506..526; Helical; Name=S3; 553..573; Helical; Name=S4; 598..619; Helical; Name=5; 655..675; Helical; Name=S6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
Pc-2PC2PKD4TRPP2
Gene Description
Polycystin 2, transient receptor potential cation channel
Chromosome
4
Position
88007635-88077777
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificCone photoreceptor cellsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Voltage-gated ion channels:Transient Receptor Potential Channels
- Human disease related genes:Congenital malformations:Congenital malformations of the urinary system
- Potential drug targets
- Transporters:Transporter channels and pores
- Predicted secreted proteins
- Disease related genes
Cellular Component
- GO:0002133 polycystin complex
- GO:0005737 cytoplasm
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005929 cilium
- GO:0009925 basal plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0030027 lamellipodium
- GO:0030659 cytoplasmic vesicle membrane
- GO:0031514 motile cilium
- GO:0034703 cation channel complex
- GO:0036064 ciliary basal body
- GO:0045180 basal cortex
- GO:0060170 ciliary membrane
- GO:0070062 extracellular exosome
- GO:0072686 mitotic spindle
- GO:0097730 non-motile cilium
- GO:0098553 lumenal side of endoplasmic reticulum membrane
- GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
- GO:0140494 migrasome
Molecular Function
- GO:0005102 signaling receptor binding
- GO:0005244 voltage-gated monoatomic ion channel activity
- GO:0005245 voltage-gated calcium channel activity
- GO:0005248 voltage-gated sodium channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0005261 monoatomic cation channel activity
- GO:0005262 calcium channel activity
- GO:0005267 potassium channel activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0008092 cytoskeletal protein binding
- GO:0015271 outward rectifier potassium channel activity
- GO:0022843 voltage-gated monoatomic cation channel activity
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0042805 actinin binding
- GO:0043398 HLH domain binding
- GO:0044325 transmembrane transporter binding
- GO:0048763 calcium-induced calcium release activity
- GO:0051117 ATPase binding
- GO:0051219 phosphoprotein binding
- GO:0051371 muscle alpha-actinin binding
- GO:0140416 transcription regulator inhibitor activity
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PKD2 | CSNK2A1 | P68400 | S | 812 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:14742446ProtMapper:14742446phosphoELM:14742446SIGNOR:14742446 |
| PKD2 | PRKD1 | Q15139 | S | 801 | phosphorylation | RLIMS-P_ProtMapperSIGNORProtMapper | SIGNOR:20881056ProtMapper:20881056 |
| PKD2 | GSK3A | P49840 | S | 76 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16551655SIGNOR:16551655 |
| PKD2 | AURKA | O14965 | S | 829 | phosphorylation | RLIMS-P_ProtMapperPhosphoSiteProtMapper | ProtMapper:21670214 |
| PKD2 | PRKACA | P17612 | S | 829 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| PKD2 | PRKD2 | Q9BZL6 | S | 801 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| PKD2 | CCKBR | P32239 | S | 244 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:17962809 |
Ligand-Receptor Signaling
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | Yes | No | No |
| cell_surface | cell_surface | OmniPath | No | No | Yes | No | No |
| receptor | receptor | scConnect | No | Yes | Yes | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | Yes | No | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | PKD2 | Q13563 | Yes | Yes | No | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:14742446ProtMapper:14742446phosphoELM:14742446KEA:14742446PhosphoSite:23838289PhosphoSite:14742446 |
| KPCD1 | Q15139 | PKD2 | Q13563 | Yes | Yes | No | iPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapper | SIGNOR:20881056ProtMapper:20881056 |
| GSK3A | P49840 | PKD2 | Q13563 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16551655PhosphoSite:16551655SIGNOR:16551655 |
| KPCD2 | Q9BZL6 | PKD2 | Q13563 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20881056PhosphoSite:20881056 |
| AURKA | O14965 | PKD2 | Q13563 | Yes | No | No | iPTMnetProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:21670214PhosphoSite:26269590PhosphoSite:23390129 |
Protein Complex Composition
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ARF1-ARL1-PKD2-ARFIP2 complex | ARF1ARFIP2ARL1PKD2 | P40616P53365P84077Q13563 | 0:0:0:0 | CORUM | CORUM:7483 | 26507660 |
| PKD2-FPC complex | PKD2PKHD1 | P08F94Q13563 | 1:1 | CompleatCORUM | Compleat:HC1555CORUM:1071 | 17008358 |
| Pkd2-Fpc-Kif3a complex | KIF3APKD2PKD2L1PKHD1 | P08F94Q13563Q9P0L9Q9Y496 | 1:1:1:1 | Compleat | Compleat:HC46 | 17283055 |
| Pkd2-Fpc-Kif3b complex | KIF3BKIF3CPKD2PKD2L1PKHD1 | O14782O15066P08F94Q13563Q9P0L9 | 1:1:1:1:1 | Compleat | Compleat:HC2654 | 17008358 |
| Pkhd1-Pkd2 complex | PKD2PKD2L1PKHD1 | P08F94Q13563Q9P0L9 | 1:1:1 | Compleat | Compleat:HC2199 | 17283055 |
| PKD2 | Q13563 | 4 | PDB | PDB:5k47PDB:5t4dPDB:6d1wPDB:9dliPDB:5mkfPDB:8k3sPDB:6t9nPDB:5mkePDB:8hk7PDB:6t9oPDB:6wb8PDB:9dwq | ||
| FAM3DPKD2 | Q13563Q96BQ1 | 0:0 | hu.MAP | |||
| FAM3DPKD2PKD2L2 | Q13563Q96BQ1Q9NZM6 | 0:0:0 | hu.MAP2 | |||
| PKD2L1 | Q9P0L9 | 6 | PDB | PDB:6du8PDB:3te3 |
Sequence, Structure & Domains
Sequences
Length
968
Mass
109,691
Sequence
MVNSSRVQPQQPGDAKRPPAPRAPDPGRLMAGCAAVGASLAAPGGLCEQRGLEIEMQRIRQAAARDPPAGAAASPSPPLSSCSRQAWSRDNPGFEAEEEEEEVEGEEGGMVVEMDVEWRPGSRRSAASSAVSSVGARSRGLGGYHGAGHPSGRRRRREDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQPRPRSSRPSSSQSTEGMEGAGGNGSSNVHV
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q13563-1; Sequence=Displayed; Name=2; Synonyms=delta6; IsoId=Q13563-2; Sequence=VSP_042479, VSP_042480; Name=3; Synonyms=delta7; IsoId=Q13563-3; Sequence=VSP_042481; Name=4; Synonyms=delta9; IsoId=Q13563-4; Sequence=VSP_042482, VSP_042483; Name=5; Synonyms=delta12/13; IsoId=Q13563-5; Sequence=VSP_042484
Alternative Sequence
476..483; CEIIFCFF -> FICSSYGD (in isoform 2); 484..968; Missing (in isoform 2); 517..572; Missing (in isoform 3); 633..646; IFTQFRIILGDINF -> IICSWRSSMIRTLK (in isoform 4); 647..968; Missing (in isoform 4); 748..841; Missing (in isoform 5)
3D Structural Models
Turn
338..340; 350..352; 431..434; 499..501; 578..580; 620..622; 670..672; 730..734; 745..747; 781..783
Helix
215..240; 244..257; 270..272; 276..284; 286..291; 328..330; 335..337; 364..366; 371..374; 399..411; 468..497; 502..504; 506..529; 530..532; 533..540; 549..571; 572..576; 581..619; 624..626; 629..641; 646..652; 656..669; 673..691; 738..744; 752..762; 773..777; 836..894
Beta Strand
262..265; 304..306; 308..326; 382..386; 390..394; 419..430; 435..444; 447..450; 452..460; 542..544; 763..766; 767..771; 793..795
3D Structure
Electron microscopy (21); NMR spectroscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
1..11; Polar residues; 62..83; Low complexity; 95..107; Acidic residues; 123..139; Low complexity; 770..795; Basic and acidic residues; 796..807; Low complexity; 938..951; Low complexity
Motif
641..643; Selectivity filter
Coiled Coil
833..872
Domain (FT)
750..785; EF-hand
Region
1..28; Disordered; 58..181; Disordered; 764..831; Disordered; 803..822; Linker; 810..821; Important for interaction with PACS1 and PACS2; 917..968; Disordered
Protein Families
Polycystin family
Sequence Similarities
Belongs to the polycystin family.
Clinical Relevance
Disease Involvement
CiliopathyDisease variant
Drugs
Interaction Protein
ENSG00000008710ENSG00000144935
Interaction Count
2
Interaction Dataset
intact_biogrid