Protein detail
IQGA2
Ras GTPase-activating-like protein IQGAP2
Protein symbol IQGA2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ras GTPase-activating-like protein IQGAP2
Protein Class
Plasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
IQ motif containing GTPase activating protein 2
Chromosome
5
Position
76403285-76708132
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-168249 innate immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013408 rhog gtpase cycle
- R-hsa-5626467 rho gtpases activate iqgaps
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IQGAP2 | PRKACA | P17612 | T | 716 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AKA11 | Q9UKA4 | IQGA2 | Q13576 | Yes | Yes | No | SIGNOR | SIGNOR:21776420 |
| KAPCA | P17612 | IQGA2 | Q13576 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:21460214PhosphoSite:21776420 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex | AKAP8LCHUKIQGAP2RELATNIP2 | O15111Q04206Q13576Q8NFZ5Q9ULX6 | 1:1:1:1:1 | CompleatCORUM | Compleat:HC814CORUM:5220 | 14743216 |
| CDC42IQGAP2 | P60953Q13576 | 4:2 | PDB | PDB:5cjp | ||
| FBXL15FBXL8IQGAP2SKP1 | P63208Q13576Q96CD0Q9H469 | 0:0:0:0 | hu.MAP | |||
| IQGAP2MTAPSUCLA2 | Q13126Q13576Q9P2R7 | 0:0:0 | hu.MAP2 | |||
| IQGAP2 | Q13576 | 2 | PDB | PDB:4ezaPDB:3iez | ||
| IQGAP2SUCLA2 | Q13576Q9P2R7 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
1,575
Mass
180,578
Sequence
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEISNMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNPNAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINKVNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYLAHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVKLEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPTANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVTLVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSWLKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSASEELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDNTDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRITLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVDPNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVNVNLLIYLLNKKFYGK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13576-1; Sequence=Displayed; Name=2; IsoId=Q13576-2; Sequence=VSP_010629, VSP_010630, VSP_010631; Name=3; IsoId=Q13576-3; Sequence=VSP_010629, VSP_055149, VSP_010631
Alternative Sequence
1..447; Missing (in isoform 2 and isoform 3); 448..453; QEENDR -> MHSLPG (in isoform 2); 448..453; QEENDR -> MGCFKG (in isoform 3); 642..698; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
912..914; 1116..1120; 1192..1194
Helix
878..894; 896..905; 908..911; 915..925; 929..950; 956..959; 963..973; 982..994; 1004..1010; 1012..1015; 1016..1018; 1031..1034; 1038..1064; 1065..1068; 1071..1087; 1093..1104; 1105..1109; 1110..1114; 1132..1149; 1159..1164; 1165..1182; 1188..1191; 1195..1198; 1223..1225; 1226..1229; 1232..1243; 1483..1488; 1500..1505; 1537..1545; 1561..1569
Beta Strand
952..955; 974..977; 1208..1214; 1479..1482; 1491..1495; 1506..1512; 1518..1525; 1528..1536; 1550..1554; 1557..1560
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
41..156; Calponin-homology (CH); 594..627; WW; 690..719; IQ 1; 720..749; IQ 2; 750..779; IQ 3; 933..1182; Ras-GAP