Protein detail
TPBG
Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)
Protein symbol TPBG | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Predicted membrane proteins |
Basic Information
Protein Names
Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1)
Protein Class
Predicted membrane proteins
Transmembrane
356..376; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
5T45T4-AG
Gene Description
Trophoblast glycoprotein
Chromosome
6
Position
82363206-82367420
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificprostateCell SpecificEsophageal apical cells
Function & Pathway
Cellular Component
Biological Process
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TPBG | Q13641 | EGFR | P00533 | Yes | Yes | No | SignaLink3 | SignaLink3:15282549SignaLink3:23331499 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
420
Mass
46,032
Sequence
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
3D Structural Models
Turn
70..73; 108..111; 135..140; 159..163; 164..166; 208..211
Helix
188..190; 195..204; 205..207; 227..232; 275..281; 300..302; 303..311; 318..320; 327..329; 334..336; 339..341
Beta Strand
67..69; 74..76; 94..97; 104..106; 122..124; 130..133; 146..148; 155..157; 177..179; 191..193; 214..216; 238..240; 262..264; 288..290; 313..316; 322..326
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Repeat
92..113; LRR 1; 116..139; LRR 2; 141..163; LRR 3; 172..204; LRR 4; 209..232; LRR 5; 233..255; LRR 6; 256..275; LRR 7
Domain (CC)
The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway.
Domain (FT)
53..91; LRRNT; 283..346; LRRCT
Clinical Relevance
Related Diseases
Biomarker
Terminated; Phase 1/2; Phase 3; Phase 2/3
Drugs
Antibody