Protein detail
I10R1
Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Entry name I10R1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 4 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Protein Function (5)
- Human disease related genes:Immune system diseases:Other immune system diseases
- CD markers
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Transmembrane
236..256; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificColonocytesSingle-Nuclei Brain Specificlower rhombic lip
Function & Pathway
Protein Function (5)
- Human disease related genes:Immune system diseases:Other immune system diseases
- CD markers
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (6)
Reactome (6)
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-9725371 nuclear events stimulated by alk signaling in cancer
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-449147 signaling by interleukins
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence79
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL10RA | TYK2 | P29597 | Y | 446 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM | phosphoELM:10433356KEA:10433356 |
| IL10RA | TYK2 | P29597 | Y | 496 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM | phosphoELM:10433356KEA:10433356 |
| IL10RA | JAK1 | P23458 | Y | 496 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEALi2012SIGNOR_ProtMapper | KEA:10433356SIGNOR:10433356HPRD:10433356ProtMapper:10433356 |
| IL10RA | JAK1 | P23458 | Y | 446 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEALi2012SIGNOR_ProtMapper | KEA:10433356SIGNOR:10433356HPRD:10433356ProtMapper:10433356 |
Ligand-Receptor Signaling (65)
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | SignaLink_function | Yes | Yes | |||
| cytokine | receptor | Almen2009 | Yes | Yes | |||
| ig_like | receptor | Almen2009 | Yes | Yes | |||
| type2_ig_like_cytokine | receptor | Almen2009 | Yes | Yes | |||
| cytokine_receptor | receptor | CellPhoneDB | Yes | Yes | |||
| interleukin | receptor | Baccin2019 | Yes | Yes | |||
| cytokine_type_2 | receptor | HPMR | Yes | Yes | |||
| type2 | receptor | Surfaceome | Yes | Yes | |||
| ig | receptor | Surfaceome | Yes | Yes | |||
| cytokiner | receptor | Surfaceome | Yes | Yes |
Regulatory Interaction Network (5)
5 records.
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL10 receptor | IL10RAIL10RB | Q08334Q13651 | 1:1 | Guide2PharmaCellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCORUMCellinkerSPIKE | CORUM:6758CellPhoneDB:IL10_receptor | 93120471503260010347215 |
| IL10-IL10RA complex | IL10IL10RA | P22301Q13651 | 1:1 | CORUMPDB | CORUM:7310PDB:1y6kPDB:1j7v | 8407942 |
| Interleukin-10 receptor-ligand complex | IL10IL10RAIL10RB | P22301Q08334Q13651 | 2:2:2 | ComplexPortalPDB | intact:EBI-59029904PDB:1Y6KPDB:1J7VPDB:6X93PDB:6x93 | 7547951316112511698260811485736147552923373746127133025 |
| IL10RAJAK1 | P23458Q13651 | 1:1 | PDB | PDB:5ixi |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37615097 |
Sequence, Structure & Domains
Sequences
Length
578
Mass
63,003
Sequence
MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE
3D Structural Models
Helix
84..87; 90..92; 120..122; 157..160; 268..270
Beta Strand
32..37; 40..45; 56..63; 70..82; 96..104; 107..113; 123..125; 128..134; 136..144; 149..151; 165..176; 181..193; 199..209; 222..225
3D Structure
Electron microscopy (1); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
316..332; Polar residues; 357..371; Low complexity; 377..396; Polar residues
Motif
318..323; BTRC recognition motif
Region
313..436; Disordered
Protein Families
Type II cytokine receptor family
Sequence Similarities
Belongs to the type II cytokine receptor family.
Clinical Relevance
Drugs
Interaction Protein (2)
ENSG00000136634ENSG00000166167
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No related sentences available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No related sentences available |