Protein detail

I10R1

Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)

Protein symbol I10R1	UniProt ID Q13651	EVMP score 0.50
Frequency 4	Transmembrane count 1	Protein classification

Basic Information

Protein Names

Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)

Protein Function

Human disease related genes:Immune system diseases:Other immune system diseases
CD markers
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

236..256; Helical

Transmembrane Count

Ensembl

ENSG00000110324

Entrez Gene Symbol

IL10RA

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificepididymisCell SpecificColonocytesSingle-Nuclei Brain Specificlower rhombic lip

Function & Pathway

Protein Function

Human disease related genes:Immune system diseases:Other immune system diseases
CD markers
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL10RA	TYK2	P29597	Y	446	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM	phosphoELM:10433356 KEA:10433356
IL10RA	TYK2	P29597	Y	496	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM	phosphoELM:10433356 KEA:10433356
IL10RA	JAK1	P23458	Y	496	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEALi2012SIGNOR_ProtMapper	KEA:10433356 SIGNOR:10433356 HPRD:10433356 ProtMapper:10433356
IL10RA	JAK1	P23458	Y	446	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEALi2012SIGNOR_ProtMapper	KEA:10433356 SIGNOR:10433356 HPRD:10433356 ProtMapper:10433356

Ligand-Receptor Signaling

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL10	P22301	I10R1	Q13651	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdbSPIKE	HPRD:11485736 LRdb:11485736 LRdb:12974481 HPRD:11717514 Lit-BM-17:11485736 DIP:15837194 SignaLink3:17208301 BioGRID:11717514 SPIKE_LC:17145710 Baccin2019:11717514 InnateDB:9568901 scConnect:19161426 CellTalkDB:12974481 connectomeDB2020:10231374 Lit-BM-17:8120391 DIP:20462497 HINT:9568901 HPRD:8897595 SPIKE:11591769 Baccin2019:11485736 HINT:20462497 HPRD:8248239 LRdb:10231374 connectomeDB2020:12974481 HPRD:7759550 IntAct:20462497 HINT:11485736 HINT:33737461 Baccin2019:7759550 InnateDB:11717514 InnateDB:10788470 HINT:10788470 connectomeDB2020:8897595 BioGRID:10231374 SIGNOR:10347215 IntAct:12513909 BioGRID:8248239 HINT:11717514 Lit-BM-17:12513909 HINT:12513909 DIP:8120391 LRdb:8248239 HPRD:10231374 LRdb:11717514 connectomeDB2020:11717514 HINT:8897595 IntAct:11485736 Lit-BM-17:10231374 SPIKE_LC:11485736 Baccin2019:8248239 SIGNOR:26260587 BioGRID:7759550 Baccin2019:10231374 SignaLink3:23331499 SignaLink3:8248239 SignaLink3:21071413 Baccin2019:12974481 Lit-BM-17:15837194 connectomeDB2020:7759550 HINT:8248239 IntAct:15837194 connectomeDB2020:8248239 HINT:7759550 SPIKE_LC:11591769 Lit-BM-17:11717514 LRdb:8897595 connectomeDB2020:11485736 HINT:10231374 BioGRID:11485736 HINT:15837194 Baccin2019:8897595 LRdb:7759550
JAK1	P23458	I10R1	Q13651	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAInnateDBLi2012HPRDphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEASIGNOR_ProtMapperHPRD-phos	SIGNOR:10433356 KEA:10433356 InnateDB:12133952 ProtMapper:10433356 HINT:12374810 HPRD-phos:10433356 BioGRID:12374810 HINT:10433356 HINT:12133952 HPRD:10433356 HPRD:12374810 HPRD:12133952
I10R1	Q13651	JAK1	P23458	Yes	Yes	No	InnateDB_SignaLink3SIGNORHPRDHINTSignaLink3BioGRIDInnateDBWang	SIGNOR:10347215 InnateDB:12133952 SignaLink3:12974481 HINT:12374810 HPRD:12374810 BioGRID:12374810 HPRD:10433356 HINT:10433356 HINT:12133952 SignaLink3:23180781 SignaLink3:23331499 HPRD:12133952 SIGNOR:26260587 SignaLink3:12133952
I10R1	Q13651	TYK2	P29597	Yes	Yes	No	WangSignaLink3	SignaLink3:23331499 SignaLink3:12974481
I10R1	Q13651	JAK2	O60674	Yes	Yes	No	WangSIGNOR	SIGNOR:26260587

Protein Complex Composition

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL10 receptor	IL10RA IL10RB	Q08334 Q13651	1:1	Guide2PharmaCellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCORUMCellinkerSPIKE	CORUM:6758CellPhoneDB:IL10_receptor	9312047 15032600 10347215
IL10-IL10RA complex	IL10 IL10RA	P22301 Q13651	1:1	CORUMPDB	CORUM:7310PDB:1y6kPDB:1j7v	8407942
Interleukin-10 receptor-ligand complex	IL10 IL10RA IL10RB	P22301 Q08334 Q13651	2:2:2	ComplexPortalPDB	intact:EBI-59029904PDB:1Y6KPDB:1J7VPDB:6X93PDB:6x93	7547951 31611251 16982608 11485736 14755292 33737461 27133025
	IL10RA JAK1	P23458 Q13651	1:1	PDB	PDB:5ixi

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37615097

Sequence, Structure & Domains

Sequences

Length

578

Mass

63,003

Sequence

MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

3D Structural Models

Helix

84..87; 90..92; 120..122; 157..160; 268..270

Beta Strand

32..37; 40..45; 56..63; 70..82; 96..104; 107..113; 123..125; 128..134; 136..144; 149..151; 165..176; 181..193; 199..209; 222..225

3D Structure

Electron microscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

316..332; Polar residues; 357..371; Low complexity; 377..396; Polar residues

Motif

318..323; BTRC recognition motif

Region

313..436; Disordered

Protein Families

Type II cytokine receptor family

Sequence Similarities

Belongs to the type II cytokine receptor family.

Clinical Relevance

Drugs

PEGILODECAKIN

Interaction Protein

ENSG00000136634ENSG00000166167

Interaction Count

Interaction Dataset

intact_biogrid