Protein detail

I10R1

Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)

Entry name I10R1	UniProt ID Q13651	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)

Protein Function (5)

Human disease related genes:Immune system diseases:Other immune system diseases
CD markers
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Transmembrane

236..256; Helical

Transmembrane Count

Ensembl

ENSG00000110324

Entrez Gene Symbol

IL10RA

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecificepididymisCell SpecificColonocytesSingle-Nuclei Brain Specificlower rhombic lip

Function & Pathway7

Protein Function (5)

Human disease related genes:Immune system diseases:Other immune system diseases
CD markers
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG (6)

Reactome (6)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence79

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL10RA	TYK2	P29597	Y	446	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM	phosphoELM:10433356 KEA:10433356
IL10RA	TYK2	P29597	Y	496	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM	phosphoELM:10433356 KEA:10433356
IL10RA	JAK1	P23458	Y	496	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEALi2012SIGNOR_ProtMapper	KEA:10433356 SIGNOR:10433356 HPRD:10433356 ProtMapper:10433356
IL10RA	JAK1	P23458	Y	446	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEALi2012SIGNOR_ProtMapper	KEA:10433356 SIGNOR:10433356 HPRD:10433356 ProtMapper:10433356

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL10	P22301	I10R1	Q13651	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdbSPIKE	HPRD:11485736 LRdb:11485736 LRdb:12974481 HPRD:11717514 Lit-BM-17:11485736 DIP:15837194 SignaLink3:17208301 BioGRID:11717514 SPIKE_LC:17145710 Baccin2019:11717514 InnateDB:9568901 scConnect:19161426 CellTalkDB:12974481 connectomeDB2020:10231374 Lit-BM-17:8120391 DIP:20462497 HINT:9568901 HPRD:8897595 SPIKE:11591769 Baccin2019:11485736 HINT:20462497 HPRD:8248239 LRdb:10231374 connectomeDB2020:12974481 HPRD:7759550 IntAct:20462497 HINT:11485736 HINT:33737461 Baccin2019:7759550 InnateDB:11717514 InnateDB:10788470 HINT:10788470 connectomeDB2020:8897595 BioGRID:10231374 SIGNOR:10347215 IntAct:12513909 BioGRID:8248239 HINT:11717514 Lit-BM-17:12513909 HINT:12513909 DIP:8120391 LRdb:8248239 HPRD:10231374 LRdb:11717514 connectomeDB2020:11717514 HINT:8897595 IntAct:11485736 Lit-BM-17:10231374 SPIKE_LC:11485736 Baccin2019:8248239 SIGNOR:26260587 BioGRID:7759550 Baccin2019:10231374 SignaLink3:23331499 SignaLink3:8248239 SignaLink3:21071413 Baccin2019:12974481 Lit-BM-17:15837194 connectomeDB2020:7759550 HINT:8248239 IntAct:15837194 connectomeDB2020:8248239 HINT:7759550 SPIKE_LC:11591769 Lit-BM-17:11717514 LRdb:8897595 connectomeDB2020:11485736 HINT:10231374 BioGRID:11485736 HINT:15837194 Baccin2019:8897595 LRdb:7759550
JAK1	P23458	I10R1	Q13651	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAInnateDBLi2012HPRDphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEASIGNOR_ProtMapperHPRD-phos	SIGNOR:10433356 KEA:10433356 InnateDB:12133952 ProtMapper:10433356 HINT:12374810 HPRD-phos:10433356 BioGRID:12374810 HINT:10433356 HINT:12133952 HPRD:10433356 HPRD:12374810 HPRD:12133952
I10R1	Q13651	JAK1	P23458	Yes	Yes	No	InnateDB_SignaLink3SIGNORHPRDHINTSignaLink3BioGRIDInnateDBWang	SIGNOR:10347215 InnateDB:12133952 SignaLink3:12974481 HINT:12374810 HPRD:12374810 BioGRID:12374810 HPRD:10433356 HINT:10433356 HINT:12133952 SignaLink3:23180781 SignaLink3:23331499 HPRD:12133952 SIGNOR:26260587 SignaLink3:12133952
I10R1	Q13651	TYK2	P29597	Yes	Yes	No	WangSignaLink3	SignaLink3:23331499 SignaLink3:12974481
I10R1	Q13651	JAK2	O60674	Yes	Yes	No	WangSIGNOR	SIGNOR:26260587

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
IL10 receptor	IL10RA IL10RB	Q08334 Q13651	1:1	Guide2PharmaCellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCORUMCellinkerSPIKE	CORUM:6758CellPhoneDB:IL10_receptor	9312047 15032600 10347215
IL10-IL10RA complex	IL10 IL10RA	P22301 Q13651	1:1	CORUMPDB	CORUM:7310PDB:1y6kPDB:1j7v	8407942
Interleukin-10 receptor-ligand complex	IL10 IL10RA IL10RB	P22301 Q08334 Q13651	2:2:2	ComplexPortalPDB	intact:EBI-59029904PDB:1Y6KPDB:1J7VPDB:6X93PDB:6x93	7547951 31611251 16982608 11485736 14755292 33737461 27133025
	IL10RA JAK1	P23458 Q13651	1:1	PDB	PDB:5ixi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	37615097

Sequence, Structure & Domains11

Sequences

Length

578

Mass

63,003

Sequence

MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE

3D Structural Models

Helix

84..87; 90..92; 120..122; 157..160; 268..270

Beta Strand

32..37; 40..45; 56..63; 70..82; 96..104; 107..113; 123..125; 128..134; 136..144; 149..151; 165..176; 181..193; 199..209; 222..225

3D Structure

Electron microscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

316..332; Polar residues; 357..371; Low complexity; 377..396; Polar residues

Motif

318..323; BTRC recognition motif

Region

313..436; Disordered

Protein Families

Type II cytokine receptor family

Sequence Similarities

Belongs to the type II cytokine receptor family.

Clinical Relevance4

Drugs

PEGILODECAKIN

Interaction Protein (2)

ENSG00000136634ENSG00000166167

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications4

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available
41201090	Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma.	No abstract available