Protein detail
AAMP
Angio-associated migratory cell protein
Entry name AAMP | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Angio-associated migratory cell protein
Protein Class (3)
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Description
Angio associated migratory cell protein
Chromosome
2
Position
218264129-218270178
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecificcervixCell SpecificAlveolar cells type 1Secretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Reactome (10)
- R-hsa-109582 hemostasis
- R-hsa-168249 innate immune system
- R-hsa-168638 nod1 2 signaling pathway
- R-hsa-168643 nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-177929 signaling by egfr
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-194138 signaling by vegf
- R-hsa-392518 signal amplification
- R-hsa-428930 thromboxane signalling through tp receptor
Mediation Categories (2)
Immune mediationReceptor-signaling mediation
Relations & Evidence10
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AAMPPOLRMTPPP6R2RIOX1RPL10 | O00411O75170P27635Q13685Q9H6W3 | 0:0:0:0:0 | hu.MAP2 | |||
| AAMPEIF6GNL2GNL3GTPBP4MRTO4NSA2PA2G4RPL5RRP1BRSL1D1RSL24D1SDAD1SLIRPZNF593 | O00488O76021O95478P46777P56537Q13685Q13823Q14684Q9BVP2Q9BZE4Q9GZT3Q9NVU7Q9UHA3Q9UKD2Q9UQ80 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6923 | ||
| AAMPRPL10RPL29RPS17SLC25A5 | P05141P08708P27635P47914Q13685 | 0:0:0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 27 | 405634752316151327863537322848253303581435611462346239183661217239766158399406412943678037786918381689063940901534817906289865852637894027894104285900903064661630950185319416063832153539558134291482393040859132089743 |
Sequence, Structure & Domains6
Sequences
Length
434
Mass
46,751
Sequence
MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPDR
Domain & Motif Annotations
Compositional Bias
39..62; Acidic residues
Repeat
89..129; WD 1; 132..171; WD 2; 173..212; WD 3; 214..254; WD 4; 258..299; WD 5; 315..354; WD 6; 356..395; WD 7; 398..433; WD 8
Region
1..63; Disordered
Clinical Relevance5
Drugs (96)
SCH 57790[3H]ACETYLCHOLINEDOTHIEPINSILAHEXOCYCLIUMACECLIDINEBETHANECHOLBRUCINEVU0255035DARIFENACINARECOLINEOTENZEPADXANOMELINEIPEROXONNC 11-1314KT 5823GALLAMINE TRIETHIODIDESTAUROSPORINEMUSCARINIC TOXIN 7CEVIMELINE[3H]TIOTROPIUMIMIPRAMINE HYDROCHLORIDEMETHSCOPOLAMINECLIDINIUMAFDX384WIN 51,708OXYBUTYNIN[3H]QNBFURTRETHONIUM IODIDEDIMETHYL-W84P-F-HHSIDHEXAHYDROSILADIFENIDOLCARBAMOYLCHOLINEIPRATROPIUM CATIONG&OUML7874TROPICAMIDEALEXA-488-TELENZEPINEVINCAMINE[3H]OXOTREMORINE-MW-84BIPERIDENWDUO3TIOTROPIUMDUO3WIN 62,577LEVETIMIDEOXOTREMORINEPILOCARPINE HYDROCHLORIDENNC 11-1607NNC 11-1585OXOTREMORINE-MMEPENZOLATETRIPITRAMINEN-BENZYL BRUCINEMETHYLFURMETHIDEC7/3-PHTHREVEFENACINN-CHLOROMETHYL-BRUCINEALCURONIUM4-DAMPSOLIFENACINACETYLCHOLINE[3H]IPEROXOTHIOCHROMEAE9C90CBHEXOCYCLIUMSCOPOLAMINEVINBURNINELY2033298CY3B-TELENZEPINEPENTYLTHIO-TZTPBRUCINE N-OXIDEDEXETIMIDEMUSCARINIC TOXIN 3ACLIDINIUM(S)-DIMETINDENEPROPANTHELINEMETHOCTRAMINEML381LITHOCHOLYLCHOLINETOLTERODINESTRYCHNINEHEXAHYDRODIFENIDOLPIRENZEPINEUH-AH 37DICYCLOMINE HYDROCHLORIDETHRX160209AQ-RA 741ARECAIDINE PROPARGYL ESTERHIMBACINEATROPINE[3H]DIMETHYL-W84LY2119620UMECLIDINIUM BROMIDEAMITRIPTYLINE HYDROCHLORIDEGLYCOPYRRONIUM
Interaction Protein (2)
ENSG00000147403ENSG00000181026
Interaction Count
2
Interaction Dataset (2)
biogrid_opencell_bioplexintact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |