Protein detail
RAPSN
43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205)
Entry name RAPSN | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205)
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (4)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CMS1DCMS1ERNF205
Gene Description
Receptor associated protein of the synapse
Chromosome
11
Position
47437764-47449143
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Function & Pathway
Protein Function (4)
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Human disease related genes:Congenital malformations:Other congenital malformations
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (6)
Biological Process (3)
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence152
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (138)
138 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0CG47_Q96LR5 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P62987_Q9H832 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P62979_P68036 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P62987_P63146 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:O14933_P0CG47 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG48_P62256 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG47_Q8N2K1 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:O14933_P62979 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG47_Q9Y2X8 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P61086_P62979 | RAPSN | Q13702 | Yes | Yes | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | RAPSNUBB | P0CG47Q13702 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RAPSNUBC | P0CG48Q13702 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RAPSNRPS27A | P62979Q13702 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | RAPSNUBA52 | P62987Q13702 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| AZU1DMXL2DNAJC3FTH1HYOU1NAGLURAPSNTOR1AUGGT1 | O14656P02794P20160P54802Q13217Q13702Q8TDJ6Q9NYU2Q9Y4L1 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7914 | ||
| DNAJC3FTH1HYOU1NAGLURAPSNSUCLA2 | P02794P54802Q13217Q13702Q9P2R7Q9Y4L1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7389 |
Sequence, Structure & Domains
Sequences
Length
412
Mass
46,328
Sequence
MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13702-1; Sequence=Displayed; Name=2; IsoId=Q13702-2; Sequence=VSP_005533
Alternative Sequence
264..322; Missing (in isoform 2)
Domain & Motif Annotations
Repeat
6..39; TPR 1; 83..116; TPR 2; 123..156; TPR 3; 163..196; TPR 4; 206..239; TPR 5; 246..279; TPR 6; 286..319; TPR 7
Zinc Finger
363..403; RING-type
Domain (CC)
A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.
Protein Families
RAPsyn family
Sequence Similarities
Belongs to the RAPsyn family.
Clinical Relevance
Disease Involvement (2)
Congenital myasthenic syndromeDisease variant
Related Diseases
Antibody
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |