Protein detail

RAPSN

43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205)

Entry name RAPSN	UniProt ID Q13702	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (4)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Ensembl

ENSG00000165917

Entrez Gene Symbol

RAPSN

Gene Synonym (3)

CMS1DCMS1ERNF205

Gene Description

Receptor associated protein of the synapse

Chromosome

Position

47437764-47449143

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway5

Protein Function (4)

Disease related genes
Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Human disease related genes:Congenital malformations:Other congenital malformations
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (6)

Biological Process (3)

Mediation Categories

Adhesion and uptake mediation

Relations & Evidence152

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (138)

138 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:P0CG48_Q96LR5	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62987_Q96B02	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P68036	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P62837	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P61081	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q15819	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P62979_Q5JXB2	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_Q9NR09	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:O14933_P0CG48	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P60604_P62979	RAPSN	Q13702	Yes	Yes	No	SIGNOR	SIGNOR:34199813

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Protein Complex Composition (6)

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:RING_E3	RAPSN UBB	P0CG47 Q13702	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RAPSN UBC	P0CG48 Q13702	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RAPSN RPS27A	P62979 Q13702	0:0	SIGNOR	SIGNOR:SIGNOR-C519
Ub:RING_E3	RAPSN UBA52	P62987 Q13702	0:0	SIGNOR	SIGNOR:SIGNOR-C519
	AZU1 DMXL2 DNAJC3 FTH1 HYOU1 NAGLU RAPSN TOR1A UGGT1	O14656 P02794 P20160 P54802 Q13217 Q13702 Q8TDJ6 Q9NYU2 Q9Y4L1	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7914
	DNAJC3 FTH1 HYOU1 NAGLU RAPSN SUCLA2	P02794 P54802 Q13217 Q13702 Q9P2R7 Q9Y4L1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7389

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	2	38207106 40189497

Sequence, Structure & Domains10

Sequences

Length

412

Mass

46,328

Sequence

MGQDQTKQQIEKGLQLYQSNQTEKALQVWTKVLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCLQNNGTRSCPNCRRSSMKPGFV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13702-1; Sequence=Displayed; Name=2; IsoId=Q13702-2; Sequence=VSP_005533

Alternative Sequence

264..322; Missing (in isoform 2)

Domain & Motif Annotations

Repeat

6..39; TPR 1; 83..116; TPR 2; 123..156; TPR 3; 163..196; TPR 4; 206..239; TPR 5; 246..279; TPR 6; 286..319; TPR 7

Zinc Finger

363..403; RING-type

Domain (CC)

A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

Protein Families

RAPsyn family

Sequence Similarities

Belongs to the RAPsyn family.

Clinical Relevance2

Disease Involvement (2)

Congenital myasthenic syndromeDisease variant

Antibody

HPA039475

Supporting Publications2

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available