Protein detail

AVR2B

Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)

Protein symbol AVR2B	UniProt ID Q13705	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

Basic Information

Protein Names

Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)

Protein Class

Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins

Protein Function

ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Potential drug targets
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:TKL Ser/Thr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Transmembrane

138..158; Helical

Transmembrane Count

Ensembl

ENSG00000114739

Entrez Gene Symbol

ACVR2B

Gene Synonym

ActR-IIB

Gene Description

Activin A receptor type 2B

Chromosome

Position

38453890-38493142

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificCardiomyocytes

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Potential drug targets
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Kinases:TKL Ser/Thr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M237 Pid vegfr1 2 pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

67 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cytokine	receptor	ICELLNET	No	Yes	No	Yes	No
cytokine_tgf	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

16 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
AVR2B	Q13705	ACV1B	P36896	Yes	Yes	No	WangInnateDB_SignaLink3iPTMnetPhosphoPointSIGNORProtMapperHPRDHINTSignaLink3BioGRIDInnateDBSIGNOR_ProtMapper	SignaLink3:18988627 SignaLink3:12364468 SignaLink3:8622651 HINT:12364468 SignaLink3:16446785 InnateDB:12364468 SignaLink3:23180781 SignaLink3:23331499 BioGRID:8622651 SIGNOR:8622651 HPRD:8622651 HINT:33961781 ProtMapper:8622651
AVR2B	Q13705	ACVL1	P37023	Yes	Yes	No	WangHINTSignaLink3	SignaLink3:23331499 HINT:22718755 SignaLink3:16446785
AVR2B	Q13705	BMR1A	P36894	Yes	Yes	No	InnateDBSignaLink3	SignaLink3:23331499 SignaLink3:16446785 InnateDB:17295905
AVR2B	Q13705	ACVR1	Q04771	Yes	Yes	No	WangPhosphoPointSignaLink3	SignaLink3:23331499 SignaLink3:16446785
AVR2B	Q13705	BMR1B	O00238	Yes	Yes	No	SignaLink3	SignaLink3:23331499 SignaLink3:16446785
INHBA	P08476	AVR2B	Q13705	Yes	Yes	No	iTALKSIGNORHINTSignaLink3HPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	CellTalkDB:9202237 connectomeDB2020:9202237 LRdb:9202237 HPRD:9202237 Baccin2019:9202237 HINT:20860622 SignaLink3:16446785 SignaLink3:23331499 HINT:22267736 SIGNOR:8622651 HINT:35005539
BMP7	P18075	AVR2B	Q13705	Yes	Yes	No	Guide2PharmaCellTalkDBFantom5_LRdbHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrSignaLink3Baccin2019Ramilowski2015_Baccin2019DLRP_talklrLRdbEMBRACERamilowski2015	CellTalkDB:9748228 Baccin2019:9748228 SIGNOR:9748228 connectomeDB2020:9748228 HPRD:9748228 SignaLink3:16446785 SignaLink3:23331499 LRdb:9748228
BMP6	P22004	AVR2B	Q13705	Yes	Yes	No	Guide2PharmaiTALKtalklrSignaLink3DLRP_talklrEMBRACE	SignaLink3:23331499 SignaLink3:16446785 SignaLink3:10504300 SignaLink3:21071413
BMP2	P12643	AVR2B	Q13705	Yes	Yes	No	iTALKHINTSignaLink3InnateDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	SignaLink3:18988627 connectomeDB2020:28977600 LRdb:15064755 HPRD:15064755 HINT:24337809 HINT:17295905 SignaLink3:15064755 SignaLink3:16446785 SignaLink3:23331499 CellTalkDB:20385559 InnateDB:17295905 Baccin2019:15064755
AVR2B	Q13705	ACV1C	Q8NER5	Yes	Yes	No	SignaLink3	SignaLink3:23331499 SignaLink3:16446785

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Protein Complex Composition

17 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ACVR_1A2B_receptor	ACVR1 ACVR2B	Q04771 Q13705	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1A2B_receptor	27481709
ACVR_1B2B_receptor	ACVR1B ACVR2B	P36896 Q13705	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1B2B_receptor	8622651 22710174 29409020 27481709 31416681 17878607 8721982
ACVR_1C2B_receptor	ACVR1C ACVR2B	Q13705 Q8NER5	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:ACVR_1C2B_receptor	8622651 22710174 27481709 17878607 8721982
BMR1A_AVR2B	ACVR2B BMPR1A	P36894 Q13705	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:BMR1A_AVR2B	18436533 27481709
BMR1B_AVR2B	ACVR2B BMPR1B	O00238 Q13705	1:1	CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker	CellPhoneDB:BMR1B_AVR2B	18436533 27481709
NODAL_receptor_IbIIb_CFC1	ACVR1B ACVR2B CFC1	P0CG37 P36896 Q13705	1:1:1	CellPhoneDBCellChatDB	CellPhoneDB:NODAL_receptor_IbIIb_CFC1
NODAL_receptor_IbIIb_TDGF1	ACVR1B ACVR2B CRIPTO	P13385 P36896 Q13705	1:1:1	CellPhoneDB	CellPhoneDB:NODAL_receptor_IbIIb_TDGF1
NODAL_receptor_IcIIb_CFC1	ACVR1C ACVR2B CFC1	P0CG37 Q13705 Q8NER5	1:1:1	CellPhoneDBCellChatDB	CellPhoneDB:NODAL_receptor_IcIIb_CFC1
NODAL_receptor_IcIIb_TDGF1	ACVR1C ACVR2B CRIPTO	P13385 Q13705 Q8NER5	1:1:1	CellPhoneDB	CellPhoneDB:NODAL_receptor_IcIIb_TDGF1
	ACVR2B BMP1 BMP2 CHRD INHBB TLL1	O43897 P09529 P12643 P13497 Q13705 Q9H2X0	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7686

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains

Sequences

Length

512

Mass

57,724

Sequence

MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=ActR-IIB2; IsoId=Q13705-1; Sequence=Displayed; Name=ActR-IIB1; IsoId=Q13705-2; Sequence=Not described

3D Structural Models

Turn

107..110; 256..258; 309..311; 413..417

Helix

36..39; 82..84; 221..223; 224..235; 273..279; 284..302; 324..326; 362..364; 367..370; 378..398; 424..431; 442..446; 448..460; 465..467; 471..482

Beta Strand

27..33; 43..49; 53..55; 57..66; 69..79; 88..91; 94..96; 98..106; 111..114; 191..197; 200..209; 212..219; 247..253; 260..266; 305..308; 312..314; 316..318; 327..329; 335..337; 344..346

3D Structure

X-ray crystallography (8)

Domain & Motif Annotations

Domain (FT)

190..480; Protein kinase

Region

491..512; Interaction with DYNLT1

Protein Families

Protein kinase superfamily
TKL Ser/Thr protein kinase family
TGFB receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantHeterotaxy

Related Diseases

Nervous system paraneoplastic/autoimmune disorder

Biomarker

Investigative

Drugs

RAMATERCEPT BIMAGRUMAB

Antibody

CAB025115 HPA040384