Protein detail
AVR2B
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Protein symbol AVR2B | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins |
Basic Information
Protein Names
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)
Protein Class
Cancer-related genesDisease related genesEnzymesHuman disease related genesPotential drug targetsPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Transmembrane
138..158; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ActR-IIB
Gene Description
Activin A receptor type 2B
Chromosome
3
Position
38453890-38493142
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificCardiomyocytes
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004712 protein serine/threonine/tyrosine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016362 activin receptor activity, type II
- GO:0017002 activin receptor activity
- GO:0019209 kinase activator activity
- GO:0019838 growth factor binding
- GO:0046872 metal ion binding
- GO:0048185 activin binding
Biological Process
KEGG
Reactome
Canonical Pathways
M237 Pid vegfr1 2 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
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Regulatory Interaction Network
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GDF11 | O95390 | AVR2B | Q13705 | Yes | Yes | No | iTALKSIGNORHINTSignaLink3HPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACEFantom5_LRdbCellTalkDBconnectomeDB2020LRdb | HPRD:16845371CellTalkDB:12414726HINT:21054789connectomeDB2020:16845371LRdb:12414726SIGNOR:12414726connectomeDB2020:12414726SIGNOR:16845371LRdb:17SignaLink3:16446785Baccin2019:1241472616845370SignaLink3:16845371SignaLink3:23331499HINT:33961781 |
| NODAL | Q96S42 | AVR2B | Q13705 | Yes | Yes | No | HPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015Reactome_LRdbconnectomeDB2020SignaLink3Baccin2019Ramilowski2015_Baccin2019WangLRdbSTRING_talklrEMBRACECellCallHPMR_talklr | Baccin2019:11952836CellTalkDB:11952836LRdb:11952836SignaLink3:16446785SignaLink3:23331499HPMR:11952836connectomeDB2020:11952836 |
| GDF5 | P43026 | AVR2B | Q13705 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrconnectomeDB2020HPRDHPRD_talklrSignaLink3Baccin2019Ramilowski2015_Baccin2019LRdbEMBRACERamilowski2015 | LRdb:8702914HPRD:8702914Baccin2019:8702914SignaLink3:8702914connectomeDB2020:8702914SignaLink3:16446785SignaLink3:23331499CellTalkDB:8702914 |
| AVR2B | Q13705 | SMAD3 | P84022 | Yes | Yes | No | SIGNOR | SIGNOR:21966641 |
| GDF8 | O14793 | AVR2B | Q13705 | Yes | Yes | No | Fantom5_LRdbCellTalkDBHPRD_LRdbiTALKtalklrSIGNORconnectomeDB2020HPRDHPRD_talklrBaccin2019Ramilowski2015_Baccin2019Lit-BM-17LRdbRamilowski2015 | Lit-BM-17:23829672HPRD:11459935SIGNOR:11459935Baccin2019:11459935CellTalkDB:11459935Lit-BM-17:11459935connectomeDB2020:11459935LRdb:11459935 |
| AVR2B | Q13705 | SMAD2 | Q15796 | Yes | Yes | No | SIGNOR | SIGNOR:21966641 |
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Protein Complex Composition
17 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACVR_1A2B_receptor | ACVR1ACVR2B | Q04771Q13705 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:ACVR_1A2B_receptor | 27481709 |
| ACVR_1B2B_receptor | ACVR1BACVR2B | P36896Q13705 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:ACVR_1B2B_receptor | 862265122710174294090202748170931416681178786078721982 |
| ACVR_1C2B_receptor | ACVR1CACVR2B | Q13705Q8NER5 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:ACVR_1C2B_receptor | 86226512271017427481709178786078721982 |
| BMR1A_AVR2B | ACVR2BBMPR1A | P36894Q13705 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:BMR1A_AVR2B | 1843653327481709 |
| BMR1B_AVR2B | ACVR2BBMPR1B | O00238Q13705 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:BMR1B_AVR2B | 1843653327481709 |
| NODAL_receptor_IbIIb_CFC1 | ACVR1BACVR2BCFC1 | P0CG37P36896Q13705 | 1:1:1 | CellPhoneDBCellChatDB | CellPhoneDB:NODAL_receptor_IbIIb_CFC1 | |
| NODAL_receptor_IbIIb_TDGF1 | ACVR1BACVR2BCRIPTO | P13385P36896Q13705 | 1:1:1 | CellPhoneDB | CellPhoneDB:NODAL_receptor_IbIIb_TDGF1 | |
| NODAL_receptor_IcIIb_CFC1 | ACVR1CACVR2BCFC1 | P0CG37Q13705Q8NER5 | 1:1:1 | CellPhoneDBCellChatDB | CellPhoneDB:NODAL_receptor_IcIIb_CFC1 | |
| NODAL_receptor_IcIIb_TDGF1 | ACVR1CACVR2BCRIPTO | P13385Q13705Q8NER5 | 1:1:1 | CellPhoneDB | CellPhoneDB:NODAL_receptor_IcIIb_TDGF1 | |
| ACVR2BBMP1BMP2CHRDINHBBTLL1 | O43897P09529P12643P13497Q13705Q9H2X0 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7686 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
512
Mass
57,724
Sequence
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=ActR-IIB2; IsoId=Q13705-1; Sequence=Displayed; Name=ActR-IIB1; IsoId=Q13705-2; Sequence=Not described
3D Structural Models
Turn
107..110; 256..258; 309..311; 413..417
Helix
36..39; 82..84; 221..223; 224..235; 273..279; 284..302; 324..326; 362..364; 367..370; 378..398; 424..431; 442..446; 448..460; 465..467; 471..482
Beta Strand
27..33; 43..49; 53..55; 57..66; 69..79; 88..91; 94..96; 98..106; 111..114; 191..197; 200..209; 212..219; 247..253; 260..266; 305..308; 312..314; 316..318; 327..329; 335..337; 344..346
3D Structure
X-ray crystallography (8)
Domain & Motif Annotations
Domain (FT)
190..480; Protein kinase
Region
491..512; Interaction with DYNLT1
Protein Families
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantHeterotaxy
Related Diseases
Biomarker
Investigative