Protein detail
CD166
CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
Protein symbol CD166 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Basic Information
Protein Names
CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
Protein Class
Cancer-related genesCD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Transmembrane
528..549; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD166MEMD
Gene Description
Activated leukocyte cell adhesion molecule
Chromosome
3
Position
105366909-105576900
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Secretome LocationSecreted in other tissuesSecretome FunctionReceptor
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | Yes | Yes | No |
| adhesion | adhesion | HGNC | Yes | Yes | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37554265 |
Sequence, Structure & Domains
Sequences
Length
583
Mass
65,102
Sequence
MESKGASSCRLLFCLLISATVFRPGLGWYTVNSAYGDTIIIPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLNLSENYTLSISNARISDEKRFVCMLVTEDNVFEAPTIVKVFKQPSKPEIVSKALFLETEQLKKLGDCISEDSYPDGNITWYRNGKVLHPLEGAVVIIFKKEMDPVTQLYTMTSTLEYKTTKADIQMPFTCSVTYYGPSGQKTIHSEQAVFDIYYPTEQVTIQVLPPKNAIKEGDNITLKCLGNGNPPPEEFLFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKKSMIASTAITVHYLDLSLNPSGEVTRQIGDALPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADEISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q13740-1; Sequence=Displayed; Name=2; IsoId=Q13740-2; Sequence=VSP_021797; Name=3; Synonyms=sALCAM; IsoId=Q13740-3; Sequence=VSP_053530, VSP_053531; Name=4; IsoId=Q13740-4; Sequence=VSP_053529, VSP_053532
Alternative Sequence
1..191; Missing (in isoform 4); 132..133; KQ -> SK (in isoform 3); 134..583; Missing (in isoform 3); 244..330; Missing (in isoform 4); 503..516; ISIPEHDEADEISD -> N (in isoform 2)
3D Structural Models
Turn
73..75; 87..89; 181..183; 194..196
Helix
84..86; 105..107; 211..213
Beta Strand
30..34; 39..41; 51..59; 65..72; 78..80; 90..92; 98..102; 109..117; 120..132; 138..141; 144..148; 152..164; 167..172; 184..192; 199..207; 218..226; 229..234; 241..243
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
569..583; Basic and acidic residues
Domain (CC)
The CD6 binding site is located in the N-terminal Ig-like domain.
Domain (FT)
28..120; Ig-like V-type 1; 125..234; Ig-like V-type 2; 245..328; Ig-like C2-type 1; 333..409; Ig-like C2-type 2; 416..501; Ig-like C2-type 3
Region
562..583; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genes
Related Diseases
Biomarker
Phase 2
Drug Targets
Clinical trial target
Drugs
FLUOROURACILKETANSERINSKF-76783PERICIAZINELY3154885NORADRENALINEBROMOCRIPTINEFENOLDOPAM MESYLATECABERGOLINEAPOMORPHINESKF-83566SKF-38393(+)-ADTNDOPAMINECLOZAPINEROTIGOTINE5-HYDROXYTRYPTAMINEUCM-1306SPIPERONEA68930PROCHLORPERAZINEN-PROPYLNORAPOMORPHINESKF-82958SCH-23390SKF-83959THIORIDAZINEFLUPHENAZINE HYDROCHLORIDELISURIDEECOPIPAM HYDROCHLORIDEFLUPENTHIXOLPERGOLIDEHALOPERIDOL DECANOATEMESORIDAZINEPRALUZATAMAB RAVTANSINE[125I]SCH23982CHLORPROMAZINE(+)-BUTACLAMOLA77636MEVIDALEN
Interaction Protein
ENSG00000013725
Interaction Count
1
Interaction Dataset
intact_biogrid