Protein detail

BMPR2

Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)

Entry name BMPR2	UniProt ID Q13873	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)

Protein Class (5)

Disease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteins

Protein Function (7)

Human disease related genes:Cardiovascular diseases:Vascular diseases
ENZYME proteins:Transferases
Human disease related genes:Cardiovascular diseases:Hypertensive diseases
Enzymes
Kinases:TKL Ser/Thr protein kinases
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

151..171; Helical

Transmembrane Count

Ensembl

ENSG00000204217

Entrez Gene Symbol

BMPR2

Gene Synonym (5)

BMPR-IIBMPR3BRK-3PPH1T-ALK

Gene Description

Bone morphogenetic protein receptor type 2

Chromosome

Position

202376327-202567751

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway7

Protein Function (7)

Human disease related genes:Cardiovascular diseases:Vascular diseases
ENZYME proteins:Transferases
Human disease related genes:Cardiovascular diseases:Hypertensive diseases
Enzymes
Kinases:TKL Ser/Thr protein kinases
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component (14)

Page 1 of 2

Molecular Function (10)

Biological Process (3)

KEGG (7)

Reactome (2)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence95

Ligand-Receptor Signaling (66)

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
act_tgfb	receptor	Surfaceome	No	Yes	No	Yes	No
cytokine	receptor	ICELLNET	No	Yes	No	Yes	No
cytokine_tgf	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network (16)

16 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BMP2	P12643	BMPR2	Q13873	Yes	Yes	No	iTALKSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPRD_LRdbInnateDB_SignaLink3talklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HINT:10712517 HINT:18342887 SignaLink3:16446785 InnateDB:17295905 Lit-BM-17:7791754 LRdb:11263668 SIGNOR:7791754LRdb:11SignaLink3:17295905 DIP:10880444 BioGRID:24337809 Lit-BM-17:10712517 SignaLink3:18342887 Baccin2019:11263668 DIP:25938661 Baccin2019:10880440 HINT:17295905 SignaLink3:23331499 InnateDB:18342887 HINT:25938661 HPRD:10880444 Lit-BM-17:10880444 connectomeDB2020:11263668 HINT:24337809 SignaLink3:23180781 HINT:10880444 connectomeDB2020:10880444
GDF5	P43026	BMPR2	Q13873	Yes	Yes	No	iTALKHINTSignaLink3InnateDBLit-BM-17HPMR_talklrHPRD_LRdbInnateDB_SignaLink3talklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallFantom5_LRdbCellTalkDBconnectomeDB2020LRdb	LRdb:8702914LRdb:953SignaLink3:18342887 HPRD:9525338Baccin2019:87029149525338HINT:18342887 HINT:9525338 HINT:19229295 Lit-BM-17:19229295 Lit-BM-17:9525338 connectomeDB2020:8702914 SignaLink3:16446785 SignaLink3:23180781 SignaLink3:23331499 connectomeDB2020:9525338 InnateDB:18342887 SignaLink3:9525338 CellTalkDB:8702914
BMPR2	Q13873	ACVR1	Q04771	Yes	Yes	No	SIGNORHINTSignaLink3WangLit-BM-17	HINT:7890683 Lit-BM-17:7890683 SIGNOR:7791754 HINT:7791754 SignaLink3:16446785 SignaLink3:23331499 SignaLink3:7791754 Lit-BM-17:7791754 SignaLink3:21071413
BMPR2	Q13873	BMR1B	O00238	Yes	Yes	No	HPRDWangSIGNORSignaLink3	SignaLink3:7791754 HPRD:10712517 SignaLink3:10712517 SignaLink3:16446785 SIGNOR:10712517 SignaLink3:23331499 SignaLink3:21071413 SIGNOR:18756288
BMP7	P18075	BMPR2	Q13873	Yes	Yes	No	iTALKSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HPRD:7791754 connectomeDB2020:7791754 HINT:7644468 HINT:18342887 HINT:7791754 Baccin2019:7791754 LRdb:7791754 SignaLink3:16446785 SIGNOR:7644468 DIP:7644468 SignaLink3:23331499 InnateDB:18342887
BMP6	P22004	BMPR2	Q13873	Yes	Yes	No	iTALKSignaLink3UniProt_LRdbHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	SignaLink3:10504300 HPRD:11401330 connectomeDB2020:10504300 SignaLink3:16446785 SignaLink3:23331499 LRdb:11401330 SignaLink3:21071413 Baccin2019:11401330
GDF6	Q6KF10	BMPR2	Q13873	Yes	Yes	No	iTALKSIGNORSignaLink3HPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019EMBRACECellCallFantom5_LRdbCellTalkDBconnectomeDB2020LRdb	SignaLink3:18988627LRdb:95HPRD:9525338 SIGNOR:16049014 CellTalkDB:16049014Baccin2019:160490149525338SignaLink3:16446785 SignaLink3:23331499 connectomeDB2020:9525338 connectomeDB2020:16049014 LRdb:16049014 SignaLink3:9525338
BMP4	P12644	BMPR2	Q13873	Yes	Yes	No	iTALKSIGNORHINTSignaLink3UniProt_LRdbDIPHPMR_talklrHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	HINT:7673243 SignaLink3:7644468 BioGRID:12045205 Baccin2019:7673243 HINT:12045205 HPRD:7644468 LRdb:7644468 SignaLink3:16446785 SIGNOR:7673243 connectomeDB2020:7644468 connectomeDB2020:7673243 HINT:28126904 Baccin2019:7644468 LRdb:7673243 HPRD:8702914 connectomeDB2020:8702914 SignaLink3:23331499 DIP:7644468 SIGNOR:8006002 SignaLink3:21071413 LRdb:8702914 HINT:7644468 Baccin2019:8702914 DIP:7673243
ANM1	Q99873	BMPR2	Q13873	Yes	Yes	No	SignaLink3	SignaLink3:23747011
BMP15	O95972	BMPR2	Q13873	Yes	Yes	No	HPMRCellTalkDBFantom5_LRdbHPMR_LRdbiTALKtalklrUniProt_LRdbRamilowski2015SIGNORconnectomeDB2020SignaLink3Baccin2019Ramilowski2015_Baccin2019DLRP_talklrWangLRdbSTRING_talklrHPMR_talklr	Baccin2019:12419820 LRdb:12419820 SIGNOR:16446785 CellTalkDB:15621726 SignaLink3:16446785 SignaLink3:23331499 connectomeDB2020:12419820 HPMR:12419820

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Protein Complex Composition (12)

12 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BMPR2 INHBB	P09529 Q13873	3:3	PDB	PDB:7u5o
	BMPR2	Q13873	2	PDB	PDB:6unpPDB:3g2f

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	29441425

Sequence, Structure & Domains14

Sequences

Length

1,038

Mass

115,201

Sequence

MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13873-1; Sequence=Displayed; Name=2; IsoId=Q13873-2; Sequence=VSP_054441, VSP_054442

Alternative Sequence

530; N -> R (in isoform 2); 531..1038; Missing (in isoform 2)

3D Structural Models

Turn

27..30; 42..47; 53..56; 105..109

Helix

48..50; 123..125; 200..202; 234..236; 237..247; 287..293; 298..315; 322..324; 380..382; 385..388; 394..396; 397..417; 421..423; 437..440; 446..453; 471..481; 488..490; 494..506

Beta Strand

33..35; 57..59; 66..73; 76..84; 90..92; 113..118; 203..211; 216..222; 225..233; 260..267; 273..279; 338..341; 347..349; 359..362

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

603..626; Low complexity; 872..896; Basic and acidic residues; 937..964; Polar residues

Domain (FT)

203..504; Protein kinase

Region

593..626; Disordered; 746..770; Disordered; 872..972; Disordered

Protein Families (3)

Protein kinase superfamily
TKL Ser/Thr protein kinase family
TGFB receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Clinical Relevance6

Disease Involvement (2)

Disease variantFDA approved drug targets

Related Diseases (4)

Joint derangement Prostate cancer Urinary system disease Urinary/pelvic organs injury

Biomarker

Investigative

Drug Targets

FDA approved drug targets

Drugs (4)

L-TRP-TRP-TRP L-PHE-PHE-PHE COHUMULONE DEXTROMETHORPHAN POLISTIREX

Antibody (2)

HPA017385 HPA049014

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available