Protein detail
BMPR2
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Entry name BMPR2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Protein Class (5)
Disease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted membrane proteins
Protein Function (7)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- ENZYME proteins:Transferases
- Human disease related genes:Cardiovascular diseases:Hypertensive diseases
- Enzymes
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
151..171; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
BMPR-IIBMPR3BRK-3PPH1T-ALK
Gene Description
Bone morphogenetic protein receptor type 2
Chromosome
2
Position
202376327-202567751
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization1
Function & Pathway7
Protein Function (7)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- ENZYME proteins:Transferases
- Human disease related genes:Cardiovascular diseases:Hypertensive diseases
- Enzymes
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component (14)
- GO:0005615 extracellular space
- GO:0005654 nucleoplasm
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0005905 clathrin-coated pit
- GO:0005912 adherens junction
- GO:0009925 basal plasma membrane
- GO:0009986 cell surface
- GO:0014069 postsynaptic density
- GO:0016324 apical plasma membrane
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Molecular Function (10)
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016362 activin receptor activity, type II
- GO:0019838 growth factor binding
- GO:0036122 BMP binding
- GO:0045296 cadherin binding
- GO:0046872 metal ion binding
- GO:0098821 BMP receptor activity
- GO:1990782 protein tyrosine kinase binding
Biological Process (3)
KEGG (7)
- hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04350 TGF-beta signaling pathway
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence95
Ligand-Receptor Signaling (66)
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| growth_factor_binder | ligand_regulator | GO_Intercell | Yes | No | No | Yes | No |
| ligand_regulator | ligand_regulator | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network (16)
16 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SMUF1 | Q9HCE7 | BMPR2 | Q13873 | Yes | No | Yes | SIGNOR | SIGNOR:22298955SIGNOR:17317136 |
| NOGG | Q13253 | BMPR2 | Q13873 | Yes | No | Yes | SIGNOR | SIGNOR:22298955SIGNOR:12478285 |
| BMR1A | P36894 | BMPR2 | Q13873 | Yes | Yes | No | MPPIPhosphoPointSIGNORHPRDCui2007DIPWang | DIP:10712517HPRD:10712517SIGNOR:10712517MPPI:10712517 |
| BMPR2 | Q13873 | BMR1A | P36894 | Yes | Yes | No | MPPISIGNORHPRDCui2007DIPWang | MPPI:10712517SIGNOR:7791754DIP:10712517HPRD:10712517SIGNOR:10712517SIGNOR:18756288 |
| CNEP1 | O95476 | BMPR2 | Q13873 | Yes | No | Yes | SIGNOR | SIGNOR:17141153 |
| SMUF2 | Q9HAU4 | BMPR2 | Q13873 | Yes | No | Yes | SIGNOR | SIGNOR:22298955 |
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Protein Complex Composition (12)
12 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACVL1_BMPR2 | ACVRL1BMPR2 | P37023Q13873 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:ACVL1_BMPR2 | 178786072271017427481709 |
| ACVR1/BMPR2 | ACVR1BMPR2 | Q04771Q13873 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBSIGNORICELLNETCellinker | CellPhoneDB:ACVR1_BMPR2SIGNOR:SIGNOR-C30 | 27481709 |
| ACVR1B_BMPR2 | ACVR1BBMPR2 | P36896Q13873 | 0:0 | CellinkerCellChatDB | ||
| BMPR1A/1B/2 | BMPR1ABMPR1BBMPR2 | O00238P36894Q13873 | 0:0:0 | SIGNOR | SIGNOR:SIGNOR-C29 | |
| BMPR1A_BMPR2 | BMPR1ABMPR2 | P36894Q13873 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:BMPR1A_BMPR2 | 1843653327481709 |
| BMPR1B_BMPR2 | BMPR1BBMPR2 | O00238Q13873 | 1:1 | CellChatDBKEGG-MEDICUSCellPhoneDBICELLNETCellinker | CellPhoneDB:BMPR1B_BMPR2 | 178786071843653327481709 |
| BMPR1B_BMPR2_ACVR1B | ACVR1BBMPR1BBMPR2 | O00238P36896Q13873 | 1:1:1 | CellPhoneDBICELLNET | CellPhoneDB:BMPR1B_BMPR2_ACVR1B | 23382188 |
| BMP2BMP7BMPR1ABMPR1BBMPR2NHP2SMAD6SMAD7TSC22D1 | O00238O15105O43541P12643P18075P36894Q13873Q15714Q9NX24 | 1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8720 | ||
| ACVRL1BMP10BMPR2 | O95393P37023Q13873 | 4:4:4 | PDB | PDB:7ppc | ||
| BMP10BMPR2 | O95393Q13873 | 2:2 | PDB | PDB:7ppaPDB:7ppb |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 29441425 |
Sequence, Structure & Domains14
Sequences
Length
1,038
Mass
115,201
Sequence
MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13873-1; Sequence=Displayed; Name=2; IsoId=Q13873-2; Sequence=VSP_054441, VSP_054442
Alternative Sequence
530; N -> R (in isoform 2); 531..1038; Missing (in isoform 2)
3D Structural Models
Turn
27..30; 42..47; 53..56; 105..109
Helix
48..50; 123..125; 200..202; 234..236; 237..247; 287..293; 298..315; 322..324; 380..382; 385..388; 394..396; 397..417; 421..423; 437..440; 446..453; 471..481; 488..490; 494..506
Beta Strand
33..35; 57..59; 66..73; 76..84; 90..92; 113..118; 203..211; 216..222; 225..233; 260..267; 273..279; 338..341; 347..349; 359..362
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
603..626; Low complexity; 872..896; Basic and acidic residues; 937..964; Polar residues
Domain (FT)
203..504; Protein kinase
Region
593..626; Disordered; 746..770; Disordered; 872..972; Disordered
Protein Families (3)
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance6
Disease Involvement (2)
Disease variantFDA approved drug targets
Related Diseases (4)
Biomarker
Investigative
Drug Targets
FDA approved drug targets
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |