Protein detail
CNGB1
Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP)
Protein symbol CNGB1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cyclic nucleotide-gated channel beta-1 (CNG channel beta-1) (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Glutamic acid-rich protein) (GARP)
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Transmembrane
657..678; Helical; Name=S1; 688..709; Helical; Name=S2; 725..744; Helical; Name=S3; 761..773; Helical; Name=S4; 786..808; Helical; Name=S5; 832..858; Helical; Name=P-helix; 859..884; Helical; Name=S6
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Transporter channels and pores
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
- GO:0001750 photoreceptor outer segment
- GO:0005886 plasma membrane
- GO:0017071 intracellular cyclic nucleotide activated cation channel complex
- GO:0030660 Golgi-associated vesicle membrane
- GO:0043195 terminal bouton
- GO:0060170 ciliary membrane
- GO:0098804 non-motile cilium membrane
- GO:0120200 rod photoreceptor outer segment
- GO:1902495 transmembrane transporter complex
Molecular Function
- GO:0005222 intracellularly cAMP-activated cation channel activity
- GO:0005223 intracellularly cGMP-activated cation channel activity
- GO:0005262 calcium channel activity
- GO:0005272 sodium channel activity
- GO:0005515 protein binding
- GO:0015276 ligand-gated monoatomic ion channel activity
- GO:0030552 cAMP binding
- GO:0030553 cGMP binding
- GO:0044877 protein-containing complex binding
Biological Process
KEGG
Reactome
- R-hsa-2485179 activation of the phototransduction cascade
- R-hsa-5620920 cargo trafficking to the periciliary membrane
- R-hsa-5617833 cilium assembly
- R-hsa-381753 olfactory signaling pathway
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-9709957 sensory perception
- R-hsa-2514856 the phototransduction cascade
- R-hsa-2187338 visual phototransduction
- R-hsa-5620916 vxpx cargo targeting to cilium
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| cyclic_nucleotide_gated | ion_channel | HGNC | No | Yes | No | No | No |
| ion_channel | ion_channel | HGNC | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 37427430 |
Sequence, Structure & Domains
Sequences
Length
1,251
Mass
139,678
Sequence
MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFKEEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHSITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVWRDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQAQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQVEPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
Alternative Products
Event=Alternative splicing; Named isoforms=4; Comment=There is no evidence for an ortholog to bovine GARP1 in the human genome.; Name=RCNC2B; IsoId=Q14028-1; Sequence=Displayed; Name=RCNC2A; IsoId=Q14028-2; Sequence=VSP_001110; Name=GARP2; Synonyms=GARP; IsoId=Q14028-3; Sequence=VSP_037921, VSP_037922; Name=4; IsoId=Q14028-4; Sequence=VSP_053421
Alternative Sequence
1..628; Missing (in isoform RCNC2A); 189..194; Missing (in isoform 4); 292..299; ISILPGGQ -> RVMGAGGL (in isoform GARP2); 300..1251; Missing (in isoform GARP2)
3D Structural Models
Turn
650..652
Helix
566..574; 654..679; 688..707; 710..712; 725..734; 736..745; 759..767; 770..782; 787..816; 833..843; 855..886; 888..906; 911..928; 933..939; 942..959; 961..963; 968..977; 1030..1033; 1059..1066; 1070..1083; 1107..1129
Beta Strand
685..687; 715..717; 720..722; 783..785; 820..824; 829..832; 929..931; 979..983; 988..990; 992..995; 998..1005; 1007..1012; 1017..1022; 1027..1029; 1036..1038; 1046..1058
3D Structure
Electron microscopy (7); NMR spectroscopy (2)
Domain & Motif Annotations
Compositional Bias
23..50; Acidic residues; 238..247; Polar residues; 335..352; Basic and acidic residues; 353..373; Acidic residues; 404..423; Basic and acidic residues; 424..434; Acidic residues; 435..446; Basic and acidic residues; 1183..1203; Pro residues; 1242..1251; Basic and acidic residues
Motif
568..578; IQ-like
Domain (CC)
The cyclic nucleotide-binding domain (CNBD) comprises three helices and a beta-roll of eight beta-strands from CNGA1 and CNGB1 subunits. Upon cNMP binding transmits the conformational changes to the C-linker domain of the S6 helix to open the ion conduction pathway.; DOMAIN: The ion conduction pathway consists of S5, S6 and pore helices from CNGA1 and CNGB1 subunits. It contains a central hydrophobic gate that opens upon cNMP binding. CNGB1 displays an additional charged arginine gate below the central gate to regulate ion permeation.
Region
1..75; Disordered; 121..151; Disordered; 172..252; Disordered; 314..561; Disordered; 557..567; Calmodulin-binding CaM1; 585..619; Disordered; 786..885; Ion conduction pathway; 888..964; C-linker; 968..1084; Cyclic nucleotide-binding domain; 1148..1154; Calmodulin-binding CaM2; 1151..1251; Disordered
Protein Families
- Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
- CNGB1 subfamily
Sequence Similarities
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily.
Clinical Relevance
Drugs